The ancient drug salicylate directly activates AMP-activated protein kinase

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Standard

The ancient drug salicylate directly activates AMP-activated protein kinase. / Hawley, Simon A.; Fullerton, Morgan D.; Ross, Fiona A.; Schertzer, Jonathan D.; Chevtzoff, Cyrille; Walker, Katherine J.; Peggie, Mark W.; Zibrova, Darya; Green, Kevin A.; Mustard, Kirsty J.; Kemp, Bruce E.; Sakamoto, Kei; Steinberg, Gregory R.; Hardie, D. Grahame.

I: Science, Bind 336, Nr. 6083, 18.05.2012, s. 918-922.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hawley, SA, Fullerton, MD, Ross, FA, Schertzer, JD, Chevtzoff, C, Walker, KJ, Peggie, MW, Zibrova, D, Green, KA, Mustard, KJ, Kemp, BE, Sakamoto, K, Steinberg, GR & Hardie, DG 2012, 'The ancient drug salicylate directly activates AMP-activated protein kinase', Science, bind 336, nr. 6083, s. 918-922. https://doi.org/10.1126/science.1215327

APA

Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R., & Hardie, D. G. (2012). The ancient drug salicylate directly activates AMP-activated protein kinase. Science, 336(6083), 918-922. https://doi.org/10.1126/science.1215327

Vancouver

Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ o.a. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012 maj 18;336(6083):918-922. https://doi.org/10.1126/science.1215327

Author

Hawley, Simon A. ; Fullerton, Morgan D. ; Ross, Fiona A. ; Schertzer, Jonathan D. ; Chevtzoff, Cyrille ; Walker, Katherine J. ; Peggie, Mark W. ; Zibrova, Darya ; Green, Kevin A. ; Mustard, Kirsty J. ; Kemp, Bruce E. ; Sakamoto, Kei ; Steinberg, Gregory R. ; Hardie, D. Grahame. / The ancient drug salicylate directly activates AMP-activated protein kinase. I: Science. 2012 ; Bind 336, Nr. 6083. s. 918-922.

Bibtex

@article{6f7f4c869f514764a16758df52b07d89,
title = "The ancient drug salicylate directly activates AMP-activated protein kinase",
abstract = "Salicylate, a plant product, has been in medicinal use since ancient times. More recently, it has been replaced by synthetic derivatives such as aspirin and salsalate, both of which are rapidly broken down to salicylate in vivo. At concentrations reached in plasma after administration of salsalate or of aspirin at high doses, salicylate activates adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cell growth and metabolism. Salicylate binds at the same site as the synthetic activator A-769662 to cause allosteric activation and inhibition of dephosphorylation of the activating phosphorylation site, threonine-172. In AMPK knockout mice, effects of salicylate to increase fat utilization and to lower plasma fatty acids in vivo were lost. Our results suggest that AMPK activation could explain some beneficial effects of salsalate and aspirin in humans.",
author = "Hawley, {Simon A.} and Fullerton, {Morgan D.} and Ross, {Fiona A.} and Schertzer, {Jonathan D.} and Cyrille Chevtzoff and Walker, {Katherine J.} and Peggie, {Mark W.} and Darya Zibrova and Green, {Kevin A.} and Mustard, {Kirsty J.} and Kemp, {Bruce E.} and Kei Sakamoto and Steinberg, {Gregory R.} and Hardie, {D. Grahame}",
year = "2012",
month = may,
day = "18",
doi = "10.1126/science.1215327",
language = "English",
volume = "336",
pages = "918--922",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6083",

}

RIS

TY - JOUR

T1 - The ancient drug salicylate directly activates AMP-activated protein kinase

AU - Hawley, Simon A.

AU - Fullerton, Morgan D.

AU - Ross, Fiona A.

AU - Schertzer, Jonathan D.

AU - Chevtzoff, Cyrille

AU - Walker, Katherine J.

AU - Peggie, Mark W.

AU - Zibrova, Darya

AU - Green, Kevin A.

AU - Mustard, Kirsty J.

AU - Kemp, Bruce E.

AU - Sakamoto, Kei

AU - Steinberg, Gregory R.

AU - Hardie, D. Grahame

PY - 2012/5/18

Y1 - 2012/5/18

N2 - Salicylate, a plant product, has been in medicinal use since ancient times. More recently, it has been replaced by synthetic derivatives such as aspirin and salsalate, both of which are rapidly broken down to salicylate in vivo. At concentrations reached in plasma after administration of salsalate or of aspirin at high doses, salicylate activates adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cell growth and metabolism. Salicylate binds at the same site as the synthetic activator A-769662 to cause allosteric activation and inhibition of dephosphorylation of the activating phosphorylation site, threonine-172. In AMPK knockout mice, effects of salicylate to increase fat utilization and to lower plasma fatty acids in vivo were lost. Our results suggest that AMPK activation could explain some beneficial effects of salsalate and aspirin in humans.

AB - Salicylate, a plant product, has been in medicinal use since ancient times. More recently, it has been replaced by synthetic derivatives such as aspirin and salsalate, both of which are rapidly broken down to salicylate in vivo. At concentrations reached in plasma after administration of salsalate or of aspirin at high doses, salicylate activates adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cell growth and metabolism. Salicylate binds at the same site as the synthetic activator A-769662 to cause allosteric activation and inhibition of dephosphorylation of the activating phosphorylation site, threonine-172. In AMPK knockout mice, effects of salicylate to increase fat utilization and to lower plasma fatty acids in vivo were lost. Our results suggest that AMPK activation could explain some beneficial effects of salsalate and aspirin in humans.

UR - http://www.scopus.com/inward/record.url?scp=84861222690&partnerID=8YFLogxK

U2 - 10.1126/science.1215327

DO - 10.1126/science.1215327

M3 - Journal article

AN - SCOPUS:84861222690

VL - 336

SP - 918

EP - 922

JO - Science

JF - Science

SN - 0036-8075

IS - 6083

ER -

ID: 239567317