The adaptability of tendon to loading differs in men and women
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The adaptability of tendon to loading differs in men and women. / Magnusson, S Peter; Hansen, Mette; Langberg, Henning; Miller, Ben; Haraldsson, Bjarki; Westh, Eva Kjoeller; Koskinen, Satu; Aagaard, Per; Kjaer, Michael.
I: International Journal of Experimental Pathology, Bind 88, Nr. 4, 2007, s. 237-40.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The adaptability of tendon to loading differs in men and women
AU - Magnusson, S Peter
AU - Hansen, Mette
AU - Langberg, Henning
AU - Miller, Ben
AU - Haraldsson, Bjarki
AU - Westh, Eva Kjoeller
AU - Koskinen, Satu
AU - Aagaard, Per
AU - Kjaer, Michael
PY - 2007
Y1 - 2007
N2 - The reason why women sustain more soft tissue injury than men during physical activity is unknown. Connective tissue properties and extracellular matrix adaptability in human tendon were investigated in models that addressed biochemical, physiological and biomechanical aspects of tendon connective tissue in response to mechanical loading. Habitual training resulted in a larger patellar tendon in men but not in women. Following an acute bout of exercise, men had an elevated tendon collagen synthesis rate and this effect was less pronounced or absent in women. Moreover, levels of circulating oestrogen affected the acute exercise-related increase in collagen synthesis. Finally, the mechanical strength of isolated tendon collagen fascicles in men surpassed that of women. Thus, compared to men, women have (i) an attenuated tendon hypertrophy response to habitual training; (ii) a lower tendon collagen synthesis rate following acute exercise; (iii) a rate of tendon collagen synthesis which is further attenuated with elevated estradiol levels; and (iv) a lower mechanical strength of their tendons. These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury.
AB - The reason why women sustain more soft tissue injury than men during physical activity is unknown. Connective tissue properties and extracellular matrix adaptability in human tendon were investigated in models that addressed biochemical, physiological and biomechanical aspects of tendon connective tissue in response to mechanical loading. Habitual training resulted in a larger patellar tendon in men but not in women. Following an acute bout of exercise, men had an elevated tendon collagen synthesis rate and this effect was less pronounced or absent in women. Moreover, levels of circulating oestrogen affected the acute exercise-related increase in collagen synthesis. Finally, the mechanical strength of isolated tendon collagen fascicles in men surpassed that of women. Thus, compared to men, women have (i) an attenuated tendon hypertrophy response to habitual training; (ii) a lower tendon collagen synthesis rate following acute exercise; (iii) a rate of tendon collagen synthesis which is further attenuated with elevated estradiol levels; and (iv) a lower mechanical strength of their tendons. These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury.
KW - Adaptation, Physiological
KW - Collagen
KW - Exercise
KW - Female
KW - Humans
KW - Male
KW - Sex Characteristics
KW - Stress, Mechanical
KW - Tendons
KW - Weight-Bearing
U2 - 10.1111/j.1365-2613.2007.00551.x
DO - 10.1111/j.1365-2613.2007.00551.x
M3 - Journal article
C2 - 17696904
VL - 88
SP - 237
EP - 240
JO - International Journal of Experimental Pathology
JF - International Journal of Experimental Pathology
SN - 0959-9673
IS - 4
ER -
ID: 38365537