The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis: relation to liver dysfunction
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The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis : relation to liver dysfunction. / Møller, S; Juul, A; Becker, U; Henriksen, J H.
I: Journal of Hepatology, Bind 32, Nr. 3, 2000, s. 441-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis
T2 - relation to liver dysfunction
AU - Møller, S
AU - Juul, A
AU - Becker, U
AU - Henriksen, J H
PY - 2000
Y1 - 2000
N2 - In the circulation, insulin-like growth factor-I (IGF-I) is bound in a trimeric complex of 150 kDa with IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). Whereas circulating IGF-I and IGFBP-3 are reported to be low in patients with chronic liver failure, the level of ALS has not been described in relation to hepatic dysfunction. The aim of the present study was therefore to measure circulating and hepatic venous concentrations of ALS in relation to hepatic function and the IGF axis.
AB - In the circulation, insulin-like growth factor-I (IGF-I) is bound in a trimeric complex of 150 kDa with IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). Whereas circulating IGF-I and IGFBP-3 are reported to be low in patients with chronic liver failure, the level of ALS has not been described in relation to hepatic dysfunction. The aim of the present study was therefore to measure circulating and hepatic venous concentrations of ALS in relation to hepatic function and the IGF axis.
M3 - Journal article
VL - 32
SP - 441
EP - 446
JO - Journal of Hepatology, Supplement
JF - Journal of Hepatology, Supplement
SN - 0169-5185
IS - 3
ER -
ID: 48486195