Ten-year clinical outcome of patients treated with a drugeluting stent in the proximal left anterior descending artery segment compared with patients stented in other non-left main coronary segments
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Ten-year clinical outcome of patients treated with a drugeluting stent in the proximal left anterior descending artery segment compared with patients stented in other non-left main coronary segments. / Kjøller-Hansen, Lars; Bligaard, Niels; Kelbæk, Henning; Christiansen, Evald H.; Thuesen, Leif; Hansen, Peter R.; Engstrøm, Thomas; Junker, Anders; Abildgaard, Ulrik; Lassen, Jens F.; Jensen, Jan S.; Jeppesen, Jørgen L.; Galløe, Anders M.
I: EuroIntervention, Bind 14, Nr. 7, 2018, s. 764-771.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Ten-year clinical outcome of patients treated with a drugeluting stent in the proximal left anterior descending artery segment compared with patients stented in other non-left main coronary segments
AU - Kjøller-Hansen, Lars
AU - Bligaard, Niels
AU - Kelbæk, Henning
AU - Christiansen, Evald H.
AU - Thuesen, Leif
AU - Hansen, Peter R.
AU - Engstrøm, Thomas
AU - Junker, Anders
AU - Abildgaard, Ulrik
AU - Lassen, Jens F.
AU - Jensen, Jan S.
AU - Jeppesen, Jørgen L.
AU - Galløe, Anders M.
PY - 2018
Y1 - 2018
N2 - Aims: The aim of the study was to determine whether patients treated with drug-eluting stents in the proximal left anterior descending artery (LAD) carried a different long-term prognosis from patients treated in other coronary artery segments. Methods and results: Ten-year clinical outcome expressed as all-cause mortality and major adverse cardiac events (MACE: Cardiac death, acute myocardial infarction, or target vessel revascularisation) was determined for 1,479 patients with a single non-left main coronary stenosis treated with a first-generation drug-eluting stent in the SORT OUT II trial. The outcome of patients treated with stents in the proximal LAD (n=365) was compared with that of patients treated in a non-proximal LAD segment (n=1,114). Follow-up was 99.3% complete. All-cause mortality was 24.9% in the proximal LAD group vs. 26.3% in the non-proximal LAD group (p=0.60). MACE occurred less frequently in the proximal LAD group, 24.6% vs. 31.0% with a hazard ratio of 0.77 (95% confidence interval [CI]: 0.61-0.97, p=0.024). After multivariate analysis which included baseline characteristics that were unevenly distributed between the groups, the hazard ratio for MACE was 0.82 (95% CI: 0.65-1.03, p=0.09). Conclusions: Patients treated with a drug-eluting stent in the proximal LAD have similar, if not better, long-term clinical outcome compared with patients stented in other coronary artery segments.
AB - Aims: The aim of the study was to determine whether patients treated with drug-eluting stents in the proximal left anterior descending artery (LAD) carried a different long-term prognosis from patients treated in other coronary artery segments. Methods and results: Ten-year clinical outcome expressed as all-cause mortality and major adverse cardiac events (MACE: Cardiac death, acute myocardial infarction, or target vessel revascularisation) was determined for 1,479 patients with a single non-left main coronary stenosis treated with a first-generation drug-eluting stent in the SORT OUT II trial. The outcome of patients treated with stents in the proximal LAD (n=365) was compared with that of patients treated in a non-proximal LAD segment (n=1,114). Follow-up was 99.3% complete. All-cause mortality was 24.9% in the proximal LAD group vs. 26.3% in the non-proximal LAD group (p=0.60). MACE occurred less frequently in the proximal LAD group, 24.6% vs. 31.0% with a hazard ratio of 0.77 (95% confidence interval [CI]: 0.61-0.97, p=0.024). After multivariate analysis which included baseline characteristics that were unevenly distributed between the groups, the hazard ratio for MACE was 0.82 (95% CI: 0.65-1.03, p=0.09). Conclusions: Patients treated with a drug-eluting stent in the proximal LAD have similar, if not better, long-term clinical outcome compared with patients stented in other coronary artery segments.
KW - Clinical trials
KW - Drug-eluting stent
KW - Stent thrombosis
U2 - 10.4244/EIJ-D-18-00396
DO - 10.4244/EIJ-D-18-00396
M3 - Journal article
C2 - 29969425
AN - SCOPUS:85054387441
VL - 14
SP - 764
EP - 771
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 7
ER -
ID: 217660721