Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark

Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark: a nationwide cohort study

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Standard

Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark : a nationwide cohort study. / Gröning, Mathis; Smerup, Morten Holdgaard; Nielsen, Dorte Guldbrand; Nissen, Henrik; Munk, Kim; Mortensen, Ulrik Markus; Andersen, Helle; Engholm, Morten; Bjerre, Jesper; Vejlstrup, Niels; Juul, Klaus; Søndergaard, Eva Vad; Jensen, Annette Schophuus; Jørgensen, Troels Højsgaard; Thyregod, Hans Gustav Hørsted; Andersen, Henrik Ørbæk; Jøns, Christian; Helvind, Morten; Sondergaard, Lars.

I: European Journal of Cardio-Thoracic Surgery, Bind 63, Nr. 2, ezad007, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gröning, M, Smerup, MH, Nielsen, DG, Nissen, H, Munk, K, Mortensen, UM, Andersen, H, Engholm, M, Bjerre, J, Vejlstrup, N, Juul, K, Søndergaard, EV, Jensen, AS, Jørgensen, TH, Thyregod, HGH, Andersen, HØ, Jøns, C, Helvind, M & Sondergaard, L 2023, 'Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark: a nationwide cohort study', European Journal of Cardio-Thoracic Surgery, bind 63, nr. 2, ezad007. https://doi.org/10.1093/ejcts/ezad007

APA

Gröning, M., Smerup, M. H., Nielsen, D. G., Nissen, H., Munk, K., Mortensen, U. M., Andersen, H., Engholm, M., Bjerre, J., Vejlstrup, N., Juul, K., Søndergaard, E. V., Jensen, A. S., Jørgensen, T. H., Thyregod, H. G. H., Andersen, H. Ø., Jøns, C., Helvind, M., & Sondergaard, L. (2023). Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark: a nationwide cohort study. European Journal of Cardio-Thoracic Surgery, 63(2), [ezad007]. https://doi.org/10.1093/ejcts/ezad007

Vancouver

Gröning M, Smerup MH, Nielsen DG, Nissen H, Munk K, Mortensen UM o.a. Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark: a nationwide cohort study. European Journal of Cardio-Thoracic Surgery. 2023;63(2). ezad007. https://doi.org/10.1093/ejcts/ezad007

Author

Gröning, Mathis ; Smerup, Morten Holdgaard ; Nielsen, Dorte Guldbrand ; Nissen, Henrik ; Munk, Kim ; Mortensen, Ulrik Markus ; Andersen, Helle ; Engholm, Morten ; Bjerre, Jesper ; Vejlstrup, Niels ; Juul, Klaus ; Søndergaard, Eva Vad ; Jensen, Annette Schophuus ; Jørgensen, Troels Højsgaard ; Thyregod, Hans Gustav Hørsted ; Andersen, Henrik Ørbæk ; Jøns, Christian ; Helvind, Morten ; Sondergaard, Lars. / Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark : a nationwide cohort study. I: European Journal of Cardio-Thoracic Surgery. 2023 ; Bind 63, Nr. 2.

Bibtex

@article{4b4ef31c32434ae2bd40ddeecac3f26d,

title = "Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark: a nationwide cohort study",

abstract = "OBJECTIVES: To assess temporal changes in the surgical management of patients with tetralogy of Fallot including the timing of interventions, surgical techniques, reinterventions and survival in a nationwide cohort. METHODS: Patients with tetralogy of Fallot in Denmark were divided into 3 eras based on their year of birth: early (1977–1991), intermediate (1992–2006) and late (2007–2021). RESULTS: The cohort consisted of 745 patients. Median follow-up was 21.2 years (13.7–30.5). There was a temporal trend towards less shunt palliation (–0.3% per year, 95% CI –0.05 to –0.1). Median age at intracardiac repair was 2.9 years (1.8–5.0), 0.8 years (0.5–1.3) and 0.5 years (0.4–0.7) (P < 0.001) in the early, intermediate and late era, respectively. There was a temporal trend towards less valve-sparing repair (–0.7% per year, 95% CI –0.5 to –1.0) and more repair with transannular patches (0.7% per year, 95% CI 0.5–1.0). Survival at 10 years was 79% (64–76), 90% (87–93) and 95% (92–98) (P < 0.001) and pulmonary valve replacement within the first 10 years after intracardiac repair was performed in 3% (1–6), 12% (8–16) and 21% (13–29) (P < 0.001) in the early, intermediate and late era, respectively. CONCLUSIONS: There was a temporal trend towards less shunt palliation and intracardiac repair at a younger age with more use of transannular patches. While survival throughout childhood and adolescence has improved, more patients undergo pulmonary valve replacement during the first 10 years after intracardiac repair.",

keywords = "Intracardiac repair, Palliative shunt, Pulmonary valve replacement, Survival, Tetralogy of Fallot, Transannular patch",

author = "Mathis Gr{\"o}ning and Smerup, {Morten Holdgaard} and Nielsen, {Dorte Guldbrand} and Henrik Nissen and Kim Munk and Mortensen, {Ulrik Markus} and Helle Andersen and Morten Engholm and Jesper Bjerre and Niels Vejlstrup and Klaus Juul and S{\o}ndergaard, {Eva Vad} and Jensen, {Annette Schophuus} and J{\o}rgensen, {Troels H{\o}jsgaard} and Thyregod, {Hans Gustav H{\o}rsted} and Andersen, {Henrik {\O}rb{\ae}k} and Christian J{\o}ns and Morten Helvind and Lars Sondergaard",

year = "2023",

doi = "10.1093/ejcts/ezad007",

language = "English",

volume = "63",

journal = "European Journal of Cardio-thoracic Surgery",

issn = "1010-7940",

publisher = "Oxford University Press",

number = "2",

}

RIS

TY - JOUR

T1 - Temporal changes in the surgical management of patients with tetralogy of Fallot in Denmark

T2 - a nationwide cohort study

AU - Gröning, Mathis

AU - Smerup, Morten Holdgaard

AU - Nielsen, Dorte Guldbrand

AU - Nissen, Henrik

AU - Munk, Kim

AU - Mortensen, Ulrik Markus

AU - Andersen, Helle

AU - Engholm, Morten

AU - Bjerre, Jesper

AU - Vejlstrup, Niels

AU - Juul, Klaus

AU - Søndergaard, Eva Vad

AU - Jensen, Annette Schophuus

AU - Jørgensen, Troels Højsgaard

AU - Thyregod, Hans Gustav Hørsted

AU - Andersen, Henrik Ørbæk

AU - Jøns, Christian

AU - Helvind, Morten

AU - Sondergaard, Lars

PY - 2023

Y1 - 2023

N2 - OBJECTIVES: To assess temporal changes in the surgical management of patients with tetralogy of Fallot including the timing of interventions, surgical techniques, reinterventions and survival in a nationwide cohort. METHODS: Patients with tetralogy of Fallot in Denmark were divided into 3 eras based on their year of birth: early (1977–1991), intermediate (1992–2006) and late (2007–2021). RESULTS: The cohort consisted of 745 patients. Median follow-up was 21.2 years (13.7–30.5). There was a temporal trend towards less shunt palliation (–0.3% per year, 95% CI –0.05 to –0.1). Median age at intracardiac repair was 2.9 years (1.8–5.0), 0.8 years (0.5–1.3) and 0.5 years (0.4–0.7) (P < 0.001) in the early, intermediate and late era, respectively. There was a temporal trend towards less valve-sparing repair (–0.7% per year, 95% CI –0.5 to –1.0) and more repair with transannular patches (0.7% per year, 95% CI 0.5–1.0). Survival at 10 years was 79% (64–76), 90% (87–93) and 95% (92–98) (P < 0.001) and pulmonary valve replacement within the first 10 years after intracardiac repair was performed in 3% (1–6), 12% (8–16) and 21% (13–29) (P < 0.001) in the early, intermediate and late era, respectively. CONCLUSIONS: There was a temporal trend towards less shunt palliation and intracardiac repair at a younger age with more use of transannular patches. While survival throughout childhood and adolescence has improved, more patients undergo pulmonary valve replacement during the first 10 years after intracardiac repair.

AB - OBJECTIVES: To assess temporal changes in the surgical management of patients with tetralogy of Fallot including the timing of interventions, surgical techniques, reinterventions and survival in a nationwide cohort. METHODS: Patients with tetralogy of Fallot in Denmark were divided into 3 eras based on their year of birth: early (1977–1991), intermediate (1992–2006) and late (2007–2021). RESULTS: The cohort consisted of 745 patients. Median follow-up was 21.2 years (13.7–30.5). There was a temporal trend towards less shunt palliation (–0.3% per year, 95% CI –0.05 to –0.1). Median age at intracardiac repair was 2.9 years (1.8–5.0), 0.8 years (0.5–1.3) and 0.5 years (0.4–0.7) (P < 0.001) in the early, intermediate and late era, respectively. There was a temporal trend towards less valve-sparing repair (–0.7% per year, 95% CI –0.5 to –1.0) and more repair with transannular patches (0.7% per year, 95% CI 0.5–1.0). Survival at 10 years was 79% (64–76), 90% (87–93) and 95% (92–98) (P < 0.001) and pulmonary valve replacement within the first 10 years after intracardiac repair was performed in 3% (1–6), 12% (8–16) and 21% (13–29) (P < 0.001) in the early, intermediate and late era, respectively. CONCLUSIONS: There was a temporal trend towards less shunt palliation and intracardiac repair at a younger age with more use of transannular patches. While survival throughout childhood and adolescence has improved, more patients undergo pulmonary valve replacement during the first 10 years after intracardiac repair.

KW - Intracardiac repair

KW - Palliative shunt

KW - Pulmonary valve replacement

KW - Survival

KW - Tetralogy of Fallot

KW - Transannular patch

U2 - 10.1093/ejcts/ezad007

DO - 10.1093/ejcts/ezad007

M3 - Journal article

C2 - 36617167

AN - SCOPUS:85158103697

VL - 63

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 2

M1 - ezad007

ER -

ID: 366994096