Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017: A nationwide study

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Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017 : A nationwide study. / Jensen, Andreas Dalsgaard; Bundgaard, Henning; Butt, Jawad Haider; Bruun, Niels Eske; Voldstedlund, Marianne; Torp-pedersen, Christian; Gislason, Gunnar; Iversen, Kasper; Chamat, Sandra; Dahl, Anders; Køber, Lars; Østergaard, Lauge; Fosbøl, Emil Loldrup.

I: International Journal of Cardiology, Bind 326, 01.03.2021, s. 145-152.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, AD, Bundgaard, H, Butt, JH, Bruun, NE, Voldstedlund, M, Torp-pedersen, C, Gislason, G, Iversen, K, Chamat, S, Dahl, A, Køber, L, Østergaard, L & Fosbøl, EL 2021, 'Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017: A nationwide study', International Journal of Cardiology, bind 326, s. 145-152. https://doi.org/10.1016/j.ijcard.2020.10.029

APA

Jensen, A. D., Bundgaard, H., Butt, J. H., Bruun, N. E., Voldstedlund, M., Torp-pedersen, C., Gislason, G., Iversen, K., Chamat, S., Dahl, A., Køber, L., Østergaard, L., & Fosbøl, E. L. (2021). Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017: A nationwide study. International Journal of Cardiology, 326, 145-152. https://doi.org/10.1016/j.ijcard.2020.10.029

Vancouver

Jensen AD, Bundgaard H, Butt JH, Bruun NE, Voldstedlund M, Torp-pedersen C o.a. Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017: A nationwide study. International Journal of Cardiology. 2021 mar. 1;326:145-152. https://doi.org/10.1016/j.ijcard.2020.10.029

Author

Jensen, Andreas Dalsgaard ; Bundgaard, Henning ; Butt, Jawad Haider ; Bruun, Niels Eske ; Voldstedlund, Marianne ; Torp-pedersen, Christian ; Gislason, Gunnar ; Iversen, Kasper ; Chamat, Sandra ; Dahl, Anders ; Køber, Lars ; Østergaard, Lauge ; Fosbøl, Emil Loldrup. / Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017 : A nationwide study. I: International Journal of Cardiology. 2021 ; Bind 326. s. 145-152.

Bibtex

@article{d05394f2b01746ff954e4141a80ffe35,
title = "Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017: A nationwide study",
abstract = "BackgroundInfective endocarditis (IE) remains a life-threatening disease, yet substantial variation in reported incidences of the disease exist. We aimed to conduct a contemporary, nationwide study of the temporal changes in incidence of IE.MethodsWe included all Danish cases of first-time IE (1997–2017) using nationwide registries. Patients were grouped into three seven-year intervals (1997–2003, 2004–2010, 2011–2017). Crude annual incidence rates (IR) per 100,000 person-years (PY) were examined overall and per subgroups: age, sex, patients without prior prosthetic heart valve or a cardiac implantable electronic device (CIED). Incidence rate ratios (IRR) were calculated adjusting for age-group, sex and diabetes.ResultsWe identified 8675 patients with IE. Over time, patients were older at diagnosis with a median age of 66.2 years (interquartile range, IQR: 51.5–76.5) and 72.2 years (IQR 62.2–79.9) in 1997–2003 and 2011–2017, respectively. The overall IR increased from 5.0/100,000 PY (95% CI: 4.4–5.6) to 10.5/100,000 PY (95% CI: 9.6–11.3) from 1997 to 2017. IR for patients without prior prosthetic heart valve or a CIED increased from 4.9/100,000 PY (95% CI: 4.3–5.5) to 6.4/100,000 PY (95% CI: 5.8–7.1) (P ≤ 0.0001 for interaction). The IR in males increased from 5.6/100,000 PY (95% CI: 4.7–6.5) to 14.2/100,000 PY (95% CI: 12.9–15.6). The IR in females increased from 4.3/100,000 PY (95% CI: 3.6–5.2) to 6.7/100,000 PY (95% CI: 5.8–7.7). IRR (adjusted for age-groups, sex and diabetes) increased over time (IRR = 1.60 (1.39–1.85) in 2017 vs 1997).ConclusionThe incidence of IE more than doubled during the study period. The increase was mainly seen among men and elderly patients only partly explained by the increase in patients with prior heart valve prosthesis or a CIED.",
author = "Jensen, {Andreas Dalsgaard} and Henning Bundgaard and Butt, {Jawad Haider} and Bruun, {Niels Eske} and Marianne Voldstedlund and Christian Torp-pedersen and Gunnar Gislason and Kasper Iversen and Sandra Chamat and Anders Dahl and Lars K{\o}ber and Lauge {\O}stergaard and Fosb{\o}l, {Emil Loldrup}",
year = "2021",
month = mar,
day = "1",
doi = "10.1016/j.ijcard.2020.10.029",
language = "English",
volume = "326",
pages = "145--152",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017

T2 - A nationwide study

AU - Jensen, Andreas Dalsgaard

AU - Bundgaard, Henning

AU - Butt, Jawad Haider

AU - Bruun, Niels Eske

AU - Voldstedlund, Marianne

AU - Torp-pedersen, Christian

AU - Gislason, Gunnar

AU - Iversen, Kasper

AU - Chamat, Sandra

AU - Dahl, Anders

AU - Køber, Lars

AU - Østergaard, Lauge

AU - Fosbøl, Emil Loldrup

PY - 2021/3/1

Y1 - 2021/3/1

N2 - BackgroundInfective endocarditis (IE) remains a life-threatening disease, yet substantial variation in reported incidences of the disease exist. We aimed to conduct a contemporary, nationwide study of the temporal changes in incidence of IE.MethodsWe included all Danish cases of first-time IE (1997–2017) using nationwide registries. Patients were grouped into three seven-year intervals (1997–2003, 2004–2010, 2011–2017). Crude annual incidence rates (IR) per 100,000 person-years (PY) were examined overall and per subgroups: age, sex, patients without prior prosthetic heart valve or a cardiac implantable electronic device (CIED). Incidence rate ratios (IRR) were calculated adjusting for age-group, sex and diabetes.ResultsWe identified 8675 patients with IE. Over time, patients were older at diagnosis with a median age of 66.2 years (interquartile range, IQR: 51.5–76.5) and 72.2 years (IQR 62.2–79.9) in 1997–2003 and 2011–2017, respectively. The overall IR increased from 5.0/100,000 PY (95% CI: 4.4–5.6) to 10.5/100,000 PY (95% CI: 9.6–11.3) from 1997 to 2017. IR for patients without prior prosthetic heart valve or a CIED increased from 4.9/100,000 PY (95% CI: 4.3–5.5) to 6.4/100,000 PY (95% CI: 5.8–7.1) (P ≤ 0.0001 for interaction). The IR in males increased from 5.6/100,000 PY (95% CI: 4.7–6.5) to 14.2/100,000 PY (95% CI: 12.9–15.6). The IR in females increased from 4.3/100,000 PY (95% CI: 3.6–5.2) to 6.7/100,000 PY (95% CI: 5.8–7.7). IRR (adjusted for age-groups, sex and diabetes) increased over time (IRR = 1.60 (1.39–1.85) in 2017 vs 1997).ConclusionThe incidence of IE more than doubled during the study period. The increase was mainly seen among men and elderly patients only partly explained by the increase in patients with prior heart valve prosthesis or a CIED.

AB - BackgroundInfective endocarditis (IE) remains a life-threatening disease, yet substantial variation in reported incidences of the disease exist. We aimed to conduct a contemporary, nationwide study of the temporal changes in incidence of IE.MethodsWe included all Danish cases of first-time IE (1997–2017) using nationwide registries. Patients were grouped into three seven-year intervals (1997–2003, 2004–2010, 2011–2017). Crude annual incidence rates (IR) per 100,000 person-years (PY) were examined overall and per subgroups: age, sex, patients without prior prosthetic heart valve or a cardiac implantable electronic device (CIED). Incidence rate ratios (IRR) were calculated adjusting for age-group, sex and diabetes.ResultsWe identified 8675 patients with IE. Over time, patients were older at diagnosis with a median age of 66.2 years (interquartile range, IQR: 51.5–76.5) and 72.2 years (IQR 62.2–79.9) in 1997–2003 and 2011–2017, respectively. The overall IR increased from 5.0/100,000 PY (95% CI: 4.4–5.6) to 10.5/100,000 PY (95% CI: 9.6–11.3) from 1997 to 2017. IR for patients without prior prosthetic heart valve or a CIED increased from 4.9/100,000 PY (95% CI: 4.3–5.5) to 6.4/100,000 PY (95% CI: 5.8–7.1) (P ≤ 0.0001 for interaction). The IR in males increased from 5.6/100,000 PY (95% CI: 4.7–6.5) to 14.2/100,000 PY (95% CI: 12.9–15.6). The IR in females increased from 4.3/100,000 PY (95% CI: 3.6–5.2) to 6.7/100,000 PY (95% CI: 5.8–7.7). IRR (adjusted for age-groups, sex and diabetes) increased over time (IRR = 1.60 (1.39–1.85) in 2017 vs 1997).ConclusionThe incidence of IE more than doubled during the study period. The increase was mainly seen among men and elderly patients only partly explained by the increase in patients with prior heart valve prosthesis or a CIED.

U2 - 10.1016/j.ijcard.2020.10.029

DO - 10.1016/j.ijcard.2020.10.029

M3 - Journal article

C2 - 33069786

VL - 326

SP - 145

EP - 152

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

ID: 285525518