Sustained postprandial decrease in plasma levels of LDL cholesterol in patients with type-2 diabetes mellitus
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Objective. Low density lipoprotein cholesterol (LDL-C) is an independent and modifiable risk factor for
development of cardiovascular disease (CVD). Postprandial lipid metabolism has been linked to CVD, but little
is known about the postprandial LDL-C profile in patients with type-2 diabetes (T2DM). We aimed to study the
postprandial levels of LDL-C in T2DM patients. Material and methods. After an overnight fast, 74 T2DM
patients, mean age approximately 60 years, were served a standard fat-rich meal of 3,515 kJ containing 54 % fat,
13 % protein and 33 % carbohydrates. Only drinking water was allowed postprandially. Blood samples were
drawn at times 0 (fasting), 1.5, 3.0, 4.5 and 6.0 h (postprandial). In all samples, LDL-C was measured with
modified beta quantification (separation by ultracentrifugation followed by measurement of infranate high
density lipoprotein cholesterol (HLD-C) using a homogeneous assay). Results. At all postprandial times, levels of
LDL-C showed highly significant (pv0.005) decreases compared to time 0 (mean [95 % CI] maximum change in
LDL-C levels at 3.0 h: 20.16 mmol/L [20.12; 20.20]; pv0.001). Independently of fasting LDL-C levels and
ongoing statin therapy, LDL-C decreased significantly more in female compared to male patients postprandially
(mean [95 % CI] maximum unadjusted change versus time 0 in LDL-C for men [n556] at 3.0 h: 20.14 mmol/L
[20.19; 20.10], pv0.001; for women [n518] at 4.5 h: 20.26 mmol/L [20.35; 20.18], pv0.001; 20.14 mmol/L
[20.24; 20.05], p50.005 between genders for the mean [95 % CI] fasting adjusted difference at 4.5 h in the
change versus time 0 in LDL-C; gender by time interaction: p50.007 (repeated measures mixed model)).
Conclusions. In T2DM patients served a fat-rich meal, levels of LDL-C decreased significantly more in women
compared to men postprandially, irrespective of fasting levels or ongoing statin therapy. This might have
implications in the atherosclerotic process and on any difference in the risk of CVD between genders.
Keywords: Cholesterol; diabetes mellitus type-2; fasting; gender; hydroxymethylglutaryl-CoA reductase
inhibitors; lipoproteins; low density lipoprotein cholesterol (LDL-C); postprandial period; statins; ultracentrifugation
Originalsprog | Engelsk |
---|---|
Tidsskrift | Scandinavian Journal of Clinical & Laboratory Investigation |
Vol/bind | 68 |
Udgave nummer | 7 |
Sider (fra-til) | 628-640 |
Antal sider | 13 |
ISSN | 0036-5513 |
DOI | |
Status | Udgivet - 2008 |
- Det tidligere LIFE - LDL
Forskningsområder
ID: 8697120