Structural basis of torque generation in the bi-directional bacterial flagellar motor

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Dokumenter

  • Fulltext

    Forlagets udgivne version, 3,46 MB, PDF-dokument

The flagellar stator unit is an oligomeric complex of two membrane proteins (MotA5B2) that powers bi-directional rotation of the bacterial flagellum. Harnessing the ion motive force across the cytoplasmic membrane, the stator unit operates as a miniature rotary motor itself to provide torque for rotation of the flagellum. Recent cryo-electron microscopic (cryo-EM) structures of the stator unit provided novel insights into its assembly, function, and subunit stoichiometry, revealing the ion flux pathway and the torque generation mechanism. Furthermore, in situ cryo-electron tomography (cryo-ET) studies revealed unprecedented details of the interactions between stator unit and rotor. In this review, we summarize recent advances in our understanding of the structure and function of the flagellar stator unit, torque generation, and directional switching of the motor.

OriginalsprogEngelsk
TidsskriftTrends in Biochemical Sciences
Vol/bind47
Udgave nummer2
Sider (fra-til)160-172
ISSN0968-0004
DOI
StatusUdgivet - 2022

Bibliografisk note

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 276699329