Structural and Functional Brain Changes in Migraine
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Structural and Functional Brain Changes in Migraine
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Migraine is a prevalent primary headache disorder and is usually considered as benign. However, structural and functional changes in the brain of individuals with migraine have been reported. High frequency of white matter abnormalities, silent infarct-like lesions, and volumetric changes in both gray and white matter in individuals with migraine compared to controls have been demonstrated. Functional magnetic resonance imaging (MRI) studies found altered connectivity in both the interictal and ictal phase of migraine. MR spectroscopy and positron emission tomography studies suggest abnormal energy metabolism and mitochondrial dysfunction, as well as other metabolic changes in individuals with migraine. In this review, we provide a brief overview of neuroimaging studies that have helped us to characterize some of these changes and discuss their limitations, including small sample sizes and poorly defined control groups. A better understanding of alterations in the brains of patients with migraine could help not only in the diagnosis but may potentially lead to the optimization of a targeted anti-migraine therapy.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Pain and Therapy |
| Vol/bind | 10 |
| Sider (fra-til) | 211-223 |
| Antal sider | 13 |
| ISSN | 2193-8237 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Paolo Martelletti and Katharina Eikermann-Haerter contributed equally to the manuscript. Sait Ashina received honoraria for consulting from Allergan, Amgen, Biohaven, Eli Lilly, Impel NeuroPharma, Novartis, Satsuma, Supernus, Theranica, Percept. He is an associate editor for Neurology Reviews and serves on Advisory Board for Journal of Headache and Pain. Enrico Bentivegna has nothing to disclose. Paolo Martelletti received Research Grants to his University Department from Allergan and Novartis, fees for webinars from Allergan, Lilly, Novartis. Fees and Royalties from SpringerNature. He is Editor-on-Chief of The Journal of Headache and Pain , Editor-in-Chief of SN Comprehensive Clinical Medicine and Expert of European Medicine Agency. Katharina Eikermann-Haerter received a Research Grant from the Massachusetts General Hospital (Schlaeger Award). She is Associated Editor of Frontiers in Neurology. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.
Publisher Copyright:
© 2021, The Author(s).
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