Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine
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Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine. / Kongshaug, K. E.; Pedersen-Bjergaard, S.; Rasmussen, K. E.; Krogh, M.
I: Chromatographia, Bind 50, Nr. 3-4, 01.09.1999, s. 247-252.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine
AU - Kongshaug, K. E.
AU - Pedersen-Bjergaard, S.
AU - Rasmussen, K. E.
AU - Krogh, M.
PY - 1999/9/1
Y1 - 1999/9/1
N2 - Impurity profiling of ecstacy and amphetamine seizures was accomplished by solid-phase microextraction (SPME) combined with capillary gas chromatography (GC). Samples were dissolved in 0.1 M aqueous acetate buffer (pH 5.0) as the only manual operation and subsequently subjected to SPME-GC. Ecstacy tablets were analyzed by head-space SPME to avoid contamination of SPME fibers with insoluble tablet components, while illicit amphetamine powders were exposed to immersed SPME. A SPME fiber of polydimethylsiloxane- divinylbenzene was found to provide excellent extraction of both polar and non-polar impurities. For both illicit ecstacy and amphetamine, complex impurity profiles were obtained by SPME providing a high information content. For ecstacy, profiles (relative peak areas) were repeatable within 2.2 to 12.6% RSD (n = 6), while similar data on amphetamine varied between 2.0 and 10.9 % RSD (n = 6). No carry-over was observed although each fiber was used for 50 to 100 extractions.
AB - Impurity profiling of ecstacy and amphetamine seizures was accomplished by solid-phase microextraction (SPME) combined with capillary gas chromatography (GC). Samples were dissolved in 0.1 M aqueous acetate buffer (pH 5.0) as the only manual operation and subsequently subjected to SPME-GC. Ecstacy tablets were analyzed by head-space SPME to avoid contamination of SPME fibers with insoluble tablet components, while illicit amphetamine powders were exposed to immersed SPME. A SPME fiber of polydimethylsiloxane- divinylbenzene was found to provide excellent extraction of both polar and non-polar impurities. For both illicit ecstacy and amphetamine, complex impurity profiles were obtained by SPME providing a high information content. For ecstacy, profiles (relative peak areas) were repeatable within 2.2 to 12.6% RSD (n = 6), while similar data on amphetamine varied between 2.0 and 10.9 % RSD (n = 6). No carry-over was observed although each fiber was used for 50 to 100 extractions.
KW - Amphetamine
KW - Capillary gas chromatography
KW - Ecstacy
KW - Solid-phase microextraction
UR - http://www.scopus.com/inward/record.url?scp=0032792567&partnerID=8YFLogxK
U2 - 10.1007/BF02490660
DO - 10.1007/BF02490660
M3 - Journal article
AN - SCOPUS:0032792567
VL - 50
SP - 247
EP - 252
JO - Chromatographia
JF - Chromatographia
SN - 0009-5893
IS - 3-4
ER -
ID: 231654479