TY - JOUR

T1 - Socioeconomic position and clinical outcomes in patients with myelodysplastic syndromes

T2 - A population-based cohort study

AU - Lauritsen, Tine Bichel

AU - Østgård, Lene Sofie Granfeldt

AU - Grønbæk, Kirsten

AU - Dalton, Susanne Oksbjerg

AU - Nørgaard, Jan Maxwell

N1 - Publisher Copyright: © 2022 The Authors. Hematological Oncology published by John Wiley & Sons Ltd.

PY - 2022

Y1 - 2022

N2 - Low socioeconomic position (SEP) may be associated with adverse outcomes in patients with myelodysplastic syndromes (MDS) inherent to for example, delayed diagnosis or reduced treatment intensity, but firm evidence is limited. In this study, we examined the association between SEP and clinical outcomes. We conducted a population-based cohort study (2010–2018) of 2233 Danish patients with MDS. SEP measures included individual-level information on education, cohabitation status and income retrieved from Statistics Denmark. Associations between SEP measures and disease severity at diagnosis were examined using binomial regression analysis. Using time-to-event analysis, we examined the association between SEP measures and treatment with allogeneic stem cell transplantation (allo-HSCT), risk of progression to acute myeloid leukemia (AML), and death. Estimates were adjusted for covariates selected based on direct acyclic graphs and reported with 95% confidence intervals. Patients with a short education were more likely to be transfusion-dependent at diagnosis (RR = 1.25, 95% CI: 1.04–1.45) and more likely to be diagnosed with higher risk MDS according to the International Prognostic Scoring System (RR = 1.29, 95% CI: 1.03–1.62), than patients with a long education. We found no clear association between SEP and risk of progression to AML. In adjusted models, the 1-year risk of dying was higher in patients with short versus long education (RR = 1.34, 95% CI: 1.08–1.65), in patients with low versus high income (RR = 1.42, 95% CI: 1.14–1.77), and among patients who lived alone compared to those who lived with a partner (RR = 1.15, 0.98–1.35). These associations persisted after 3 years and 5 years of follow-up. Notably, patients with a short education had a markedly lower rate of undergoing treatment with allo-HSCT compared to patients with a long education (HR = 0.51, 95% CI: 0.31–0.84). In conclusion, low SEP and especially short education, were poor prognostic factors for adverse clinical outcomes among patients with MDS.

AB - Low socioeconomic position (SEP) may be associated with adverse outcomes in patients with myelodysplastic syndromes (MDS) inherent to for example, delayed diagnosis or reduced treatment intensity, but firm evidence is limited. In this study, we examined the association between SEP and clinical outcomes. We conducted a population-based cohort study (2010–2018) of 2233 Danish patients with MDS. SEP measures included individual-level information on education, cohabitation status and income retrieved from Statistics Denmark. Associations between SEP measures and disease severity at diagnosis were examined using binomial regression analysis. Using time-to-event analysis, we examined the association between SEP measures and treatment with allogeneic stem cell transplantation (allo-HSCT), risk of progression to acute myeloid leukemia (AML), and death. Estimates were adjusted for covariates selected based on direct acyclic graphs and reported with 95% confidence intervals. Patients with a short education were more likely to be transfusion-dependent at diagnosis (RR = 1.25, 95% CI: 1.04–1.45) and more likely to be diagnosed with higher risk MDS according to the International Prognostic Scoring System (RR = 1.29, 95% CI: 1.03–1.62), than patients with a long education. We found no clear association between SEP and risk of progression to AML. In adjusted models, the 1-year risk of dying was higher in patients with short versus long education (RR = 1.34, 95% CI: 1.08–1.65), in patients with low versus high income (RR = 1.42, 95% CI: 1.14–1.77), and among patients who lived alone compared to those who lived with a partner (RR = 1.15, 0.98–1.35). These associations persisted after 3 years and 5 years of follow-up. Notably, patients with a short education had a markedly lower rate of undergoing treatment with allo-HSCT compared to patients with a long education (HR = 0.51, 95% CI: 0.31–0.84). In conclusion, low SEP and especially short education, were poor prognostic factors for adverse clinical outcomes among patients with MDS.

KW - myelodysplastic syndromes

KW - outcomes

KW - prognosis

KW - socioeconomic position

U2 - 10.1002/hon.3068

DO - 10.1002/hon.3068

M3 - Journal article

C2 - 35997314

AN - SCOPUS:85138287305

VL - 40

SP - 1056

EP - 1066

JO - Hematological Oncology

JF - Hematological Oncology

SN - 0278-0232

IS - 5

ER -