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Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases. / Thorsson, Hanna; Henningsson, Rasmus; Puente-moncada, Noelia; Sjöström, Ludvig; Ågerstam, Helena; Peña-martínez, Pablo Enrique; Sandén, Carl; Rissler, Marianne; Castor, Anders; Marquart, Hanne Vibeke; Modvig, Signe; Paulsson, Kajsa; Pronk, Cornelis; Schmiegelow, Kjeld; Hyrenius Wittsten, Axel; Orsmark-pietras, Christina; Lilljebjörn, Henrik Phd; Fioretos, Thoas.
I:
Blood, Bind 142, Nr. Supplement 1, 2023, s. 842.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Thorsson, H, Henningsson, R, Puente-moncada, N, Sjöström, L, Ågerstam, H, Peña-martínez, PE, Sandén, C, Rissler, M, Castor, A
, Marquart, HV, Modvig, S, Paulsson, K, Pronk, C
, Schmiegelow, K, Hyrenius Wittsten, A, Orsmark-pietras, C, Lilljebjörn, HP & Fioretos, T 2023, '
Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases',
Blood, bind 142, nr. Supplement 1, s. 842.
https://doi.org/10.1182/blood-2023-173350APA
Thorsson, H., Henningsson, R., Puente-moncada, N., Sjöström, L., Ågerstam, H., Peña-martínez, P. E., Sandén, C., Rissler, M., Castor, A.
, Marquart, H. V., Modvig, S., Paulsson, K., Pronk, C.
, Schmiegelow, K., Hyrenius Wittsten, A., Orsmark-pietras, C., Lilljebjörn, H. P., & Fioretos, T. (2023).
Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases.
Blood,
142(Supplement 1), 842.
https://doi.org/10.1182/blood-2023-173350Vancouver
Thorsson H, Henningsson R, Puente-moncada N, Sjöström L, Ågerstam H, Peña-martínez PE o.a.
Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases.
Blood. 2023;142(Supplement 1):842.
https://doi.org/10.1182/blood-2023-173350Author
Thorsson, Hanna ; Henningsson, Rasmus ; Puente-moncada, Noelia ; Sjöström, Ludvig ; Ågerstam, Helena ; Peña-martínez, Pablo Enrique ; Sandén, Carl ; Rissler, Marianne ; Castor, Anders ; Marquart, Hanne Vibeke ; Modvig, Signe ; Paulsson, Kajsa ; Pronk, Cornelis ; Schmiegelow, Kjeld ; Hyrenius Wittsten, Axel ; Orsmark-pietras, Christina ; Lilljebjörn, Henrik Phd ; Fioretos, Thoas. / Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases. I: Blood. 2023 ; Bind 142, Nr. Supplement 1. s. 842.
Bibtex
@article{102072d5a92d4ad08eb96186fedfd21b,
title = "Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases",
abstract = "B cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy. It is initiated by multiple genetic alterations, causing a maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes, but are associated with significant toxicity and risk of side effects, highlighting the necessity for highly effective, less toxic, targeted drugs that also show efficacy in children experiencing relapse.",
author = "Hanna Thorsson and Rasmus Henningsson and Noelia Puente-moncada and Ludvig Sj{\"o}str{\"o}m and Helena {\AA}gerstam and Pe{\~n}a-mart{\'i}nez, {Pablo Enrique} and Carl Sand{\'e}n and Marianne Rissler and Anders Castor and Marquart, {Hanne Vibeke} and Signe Modvig and Kajsa Paulsson and Cornelis Pronk and Kjeld Schmiegelow and {Hyrenius Wittsten}, Axel and Christina Orsmark-pietras and Lilljebj{\"o}rn, {Henrik Phd} and Thoas Fioretos",
year = "2023",
doi = "10.1182/blood-2023-173350",
language = "English",
volume = "142",
pages = "842",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "Supplement 1",
}
RIS
TY - JOUR
T1 - Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases
AU - Thorsson, Hanna
AU - Henningsson, Rasmus
AU - Puente-moncada, Noelia
AU - Sjöström, Ludvig
AU - Ågerstam, Helena
AU - Peña-martínez, Pablo Enrique
AU - Sandén, Carl
AU - Rissler, Marianne
AU - Castor, Anders
AU - Marquart, Hanne Vibeke
AU - Modvig, Signe
AU - Paulsson, Kajsa
AU - Pronk, Cornelis
AU - Schmiegelow, Kjeld
AU - Hyrenius Wittsten, Axel
AU - Orsmark-pietras, Christina
AU - Lilljebjörn, Henrik Phd
AU - Fioretos, Thoas
PY - 2023
Y1 - 2023
N2 - B cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy. It is initiated by multiple genetic alterations, causing a maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes, but are associated with significant toxicity and risk of side effects, highlighting the necessity for highly effective, less toxic, targeted drugs that also show efficacy in children experiencing relapse.
AB - B cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy. It is initiated by multiple genetic alterations, causing a maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes, but are associated with significant toxicity and risk of side effects, highlighting the necessity for highly effective, less toxic, targeted drugs that also show efficacy in children experiencing relapse.
U2 - 10.1182/blood-2023-173350
DO - 10.1182/blood-2023-173350
M3 - Journal article
VL - 142
SP - 842
JO - Blood
JF - Blood
SN - 0006-4971
IS - Supplement 1
ER -
