Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations

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Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations. / Svenningsen, Mikkel Skjoldan; Mitarai, Namiko.

I: Physical Review Research, Bind 6, Nr. 3, 033072, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Svenningsen, MS & Mitarai, N 2024, 'Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations', Physical Review Research, bind 6, nr. 3, 033072. https://doi.org/10.1103/PhysRevResearch.6.033072

APA

Svenningsen, M. S., & Mitarai, N. (2024). Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations. Physical Review Research, 6(3), [033072]. https://doi.org/10.1103/PhysRevResearch.6.033072

Vancouver

Svenningsen MS, Mitarai N. Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations. Physical Review Research. 2024;6(3). 033072. https://doi.org/10.1103/PhysRevResearch.6.033072

Author

Svenningsen, Mikkel Skjoldan ; Mitarai, Namiko. / Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations. I: Physical Review Research. 2024 ; Bind 6, Nr. 3.

Bibtex

@article{4da7bb0f2a6946c684f940b9fec654d7,

title = "Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations",

abstract = "Bacterial persistence is a phenomenon where a subpopulation of cells can survive antibiotic treatment, and it is often linked to extremely slow growth or a dormant state. However, the mechanisms and factors that govern dormancy are not well understood. We propose a simplified growth model that treats the main cellular components as discrete variables and allocates resources among them according to different strategies. The model can reproduce some of the observed features of bacterial persistence, such as wide distribution in division times, long division times after a nutrient downshift, and the existence of different dormant phenotypes. We also show how the growth structure, i.e., whether cells grow in a lineage or a branch, affects the dormant cells' occurrence and distribution due to the growth states' mother-daughter correlation. Our model provides a framework to explore the complex interactions between cellular processes and environmental conditions that lead to bacterial persistence. ",

author = "Svenningsen, {Mikkel Skjoldan} and Namiko Mitarai",

note = "Publisher Copyright: {\textcopyright} 2024 American Physical Society.",

year = "2024",

doi = "10.1103/PhysRevResearch.6.033072",

language = "English",

volume = "6",

journal = "Physical Review Research",

issn = "2643-1564",

publisher = "AMER PHYSICAL SOC",

number = "3",

}

RIS

TY - JOUR

T1 - Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations

AU - Svenningsen, Mikkel Skjoldan

AU - Mitarai, Namiko

PY - 2024

Y1 - 2024

N2 - Bacterial persistence is a phenomenon where a subpopulation of cells can survive antibiotic treatment, and it is often linked to extremely slow growth or a dormant state. However, the mechanisms and factors that govern dormancy are not well understood. We propose a simplified growth model that treats the main cellular components as discrete variables and allocates resources among them according to different strategies. The model can reproduce some of the observed features of bacterial persistence, such as wide distribution in division times, long division times after a nutrient downshift, and the existence of different dormant phenotypes. We also show how the growth structure, i.e., whether cells grow in a lineage or a branch, affects the dormant cells' occurrence and distribution due to the growth states' mother-daughter correlation. Our model provides a framework to explore the complex interactions between cellular processes and environmental conditions that lead to bacterial persistence.

AB - Bacterial persistence is a phenomenon where a subpopulation of cells can survive antibiotic treatment, and it is often linked to extremely slow growth or a dormant state. However, the mechanisms and factors that govern dormancy are not well understood. We propose a simplified growth model that treats the main cellular components as discrete variables and allocates resources among them according to different strategies. The model can reproduce some of the observed features of bacterial persistence, such as wide distribution in division times, long division times after a nutrient downshift, and the existence of different dormant phenotypes. We also show how the growth structure, i.e., whether cells grow in a lineage or a branch, affects the dormant cells' occurrence and distribution due to the growth states' mother-daughter correlation. Our model provides a framework to explore the complex interactions between cellular processes and environmental conditions that lead to bacterial persistence.

U2 - 10.1103/PhysRevResearch.6.033072

DO - 10.1103/PhysRevResearch.6.033072

M3 - Journal article

AN - SCOPUS:85198907274

VL - 6

JO - Physical Review Research

JF - Physical Review Research

SN - 2643-1564

IS - 3

M1 - 033072

ER -

ID: 399663786