Standard
Shared genetic risk between eating disorder- and substance-use-related phenotypes : Evidence from genome-wide association studies. / Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi Ling; Coleman, Jonathan R.I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hübel, Christopher; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M.; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A.; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Boraska Perica, Vesna; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M.; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J.; Forzan, Monica; Franklin, Christopher S.; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Gratacos Mayora, Monica; Guillaume, Sébastien; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G.; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, James L.; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl Ri; Klump, Kelly L.; Knudsen, Gun Peggy S.; La Via, Maria C.; Le Hellard, Stephanie; Levitan, Robert D.; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J.; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R.; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O'Toole, Julie K.; Ophoff, Roel A.; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Scherer, Stephen W.; Schmidt, Ulrike; Schork, Nicholas J.; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P. Eline; Slof-Op't Landt, Margarita C.T.; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata; Szatkiewicz, Jin P.; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A.; van Furth, Eric F.; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W.; Boden, Joseph M.; Brandt, Harry; Crawford, Steven; Halmi, Katherine A.; Horwood, L. John; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Mitchell, James; Olsen, Catherine M.; Pearson, John F.; Pedersen, Nancy L.; Strober, Michael; Werge, Thomas; Whiteman, David C.; Woodside, D. Blake; Grove, Jakob; Henders, Anjali K.; Larsen, Janne T.; Parker, Richard; Petersen, Liselotte V.; Jordan, Jennifer; Kennedy, Martin A.; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; Mortensen, Preben Bo; Polimanti, Renato; McClintick, Jeanette N.; Adkins, Amy E.; Aliev, Fazil; Bacanu, Silviu Alin; Batzler, Anthony; Bertelsen, Sarah; Biernacka, Joanna M.; Bigdeli, Tim B.; Chen, Li Shiun; Clarke, Toni Kim; Degenhardt, Franziska; Docherty, Anna R.; Edwards, Alexis C.; Foo, Jerome C.; Fox, Louis; Frank, Josef; Hack, Laura M.; Hartmann, Annette M.; Hartz, Sarah M.; Heilmann-Heimbach, Stefanie; Hodgkinson, Colin; Hoffmann, Per; Hottenga, Jouke Jan; Konte, Bettina; Lahti, Jari; Lahti-Pulkkinen, Marius; Lai, Dongbing; Ligthart, Lannie; Loukola, Anu; Maher, Brion S.; Mbarek, Hamdi; McIntosh, Andrew M.; McQueen, Matthew B.; Meyers, Jacquelyn L.; Milaneschi, Yuri; Palviainen, Teemu; Peterson, Roseann E.; Ryu, Euijung; Saccone, Nancy L.; Salvatore, Jessica E.; Sanchez-Roige, Sandra; Schwandt, Melanie; Sherva, Richard; Streit, Fabian; Strohmaier, Jana; Thomas, Nathaniel; Wang, Jen Chyong; Webb, Bradley T.; Wedow, Robbee; Wetherill, Leah; Wills, Amanda G.; Zhou, Hang; Boardman, Jason D.; Chen, Danfeng; Choi, Doo Sup; Copeland, William E.; Culverhouse, Robert C.; Dahmen, Norbert; Degenhardt, Louisa; Domingue, Benjamin W.; Frye, Mark A.; Gäbel, Wolfgang; Hayward, Caroline; Ising, Marcus; Keyes, Margaret; Kiefer, Falk; Koller, Gabriele; Kramer, John; Kuperman, Samuel; Lucae, Susanne; Lynskey, Michael T.; Maier, Wolfgang; Mann, Karl; Männistö, Satu; Müller-Myhsok, Bertram; Murray, Alison D.; Nurnberger, John I.; Preuss, Ulrich; Räikkönen, Katri; Reynolds, Maureen D.; Ridinger, Monika; Scherbaum, Norbert; Schuckit, Marc A.; Soyka, Michael; Treutlein, Jens; Witt, Stephanie H.; Wodarz, Norbert; Zill, Peter; Adkins, Daniel E.; Boomsma, Dorret I.; Bierut, Laura J.; Brown, Sandra A.; Bucholz, Kathleen K.; Costello, E. Jane; de Wit, Harriet; Diazgranados, Nancy; Eriksson, Johan G.; Farrer, Lindsay A.; Foroud, Tatiana M.; Gillespie, Nathan A.; Goate, Alison M.; Goldman, David; Grucza, Richard A.; Hancock, Dana B.; Harris, Kathleen Mullan; Hesselbrock, Victor; Hewitt, John K.; Hopfer, Christian J.; Iacono, William G.; Johnson, Eric O.; Karpyak, Victor M.; Kendler, Kenneth S.; Kranzler, Henry R.; Krauter, Kenneth; Lind, Penelope A.; McGue, Matt; MacKillop, James; Madden, Pamela A.F.; Maes, Hermine H.; Magnusson, Patrik K.E.; Nelson, Elliot C.; Nöthen, Markus M.; Palmer, Abraham A.; Penninx, Brenda W.J.H.; Porjesz, Bernice; Rice, John P.; Rietschel, Marcella; Riley, Brien P.; Rose, Richard J.; Shen, Pei Hong; Silberg, Judy; Stallings, Michael C.; Tarter, Ralph E.; Vanyukov, Michael M.; Vrieze, Scott; Wall, Tamara L.; Whitfield, John B.; Zhao, Hongyu; Neale, Benjamin M.; Wade, Tracey D.; Heath, Andrew C.; Montgomery, Grant W.; Martin, Nicholas G.; Sullivan, Patrick F.; Kaprio, Jaakko; Breen, Gerome; Gelernter, Joel; Edenberg, Howard J.; Bulik, Cynthia M.; Agrawal, Arpana.
I:
Addiction Biology (Online), Bind 26, Nr. 1, e12880, 2020.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Munn-Chernoff, MA, Johnson, EC, Chou, YL, Coleman, JRI, Thornton, LM, Walters, RK, Yilmaz, Z, Baker, JH, Hübel, C, Gordon, S, Medland, SE, Watson, HJ, Gaspar, HA, Bryois, J, Hinney, A, Leppä, VM, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, KB, Adan, RAH, Alfredsson, L, Ando, T, Andreassen, OA, Berrettini, WH, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, RD, Courtet, P, Crow, S, Crowley, JJ, Danner, UN, Davis, OSP, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, JE, Dick, DM, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, LE, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, MM, Fischer, K, Föcker, M, Foretova, L, Forstner, AJ, Forzan, M, Franklin, CS, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, SG, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, LM, Hudson, JI, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, MJH, Kennedy, JL, Keski-Rahkonen, A, Kiezebrink, K, Kim, YR, Klump, KL, Knudsen, GPS, La Via, MC, Le Hellard, S, Levitan, RD, Li, D, Lilenfeld, L, Lin, BD, Lissowska, J, Luykx, J, Magistretti, PJ, Maj, M, Mannik, K, Marsal, S, Marshall, CR, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, AM, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, JK, Ophoff, RA, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, SW, Schmidt, U, Schork, NJ, Schosser, A, Seitz, J, Slachtova, L, Slagboom, PE, Slof-Op't Landt, MCT, Slopien, A, Sorbi, S, Świątkowska, B, Szatkiewicz, JP, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, AA, van Furth, EF, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, AW, Boden, JM, Brandt, H, Crawford, S, Halmi, KA, Horwood, LJ, Johnson, C, Kaplan, AS, Kaye, WH, Mitchell, J, Olsen, CM, Pearson, JF, Pedersen, NL, Strober, M
, Werge, T, Whiteman, DC, Woodside, DB, Grove, J, Henders, AK, Larsen, JT, Parker, R, Petersen, LV, Jordan, J, Kennedy, MA, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, PB, Polimanti, R, McClintick, JN, Adkins, AE, Aliev, F, Bacanu, SA, Batzler, A, Bertelsen, S, Biernacka, JM, Bigdeli, TB, Chen, LS, Clarke, TK, Degenhardt, F, Docherty, AR, Edwards, AC, Foo, JC, Fox, L, Frank, J, Hack, LM, Hartmann, AM, Hartz, SM, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, JJ, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, BS, Mbarek, H, McIntosh, AM, McQueen, MB, Meyers, JL, Milaneschi, Y, Palviainen, T, Peterson, RE, Ryu, E, Saccone, NL, Salvatore, JE, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, JC, Webb, BT, Wedow, R, Wetherill, L, Wills, AG, Zhou, H, Boardman, JD, Chen, D, Choi, DS, Copeland, WE, Culverhouse, RC, Dahmen, N, Degenhardt, L, Domingue, BW, Frye, MA, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J, Kuperman, S, Lucae, S, Lynskey, MT, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, AD, Nurnberger, JI, Preuss, U, Räikkönen, K, Reynolds, MD, Ridinger, M, Scherbaum, N, Schuckit, MA, Soyka, M, Treutlein, J, Witt, SH, Wodarz, N, Zill, P, Adkins, DE, Boomsma, DI, Bierut, LJ, Brown, SA, Bucholz, KK, Costello, EJ, de Wit, H, Diazgranados, N, Eriksson, JG, Farrer, LA, Foroud, TM, Gillespie, NA, Goate, AM, Goldman, D, Grucza, RA, Hancock, DB, Harris, KM, Hesselbrock, V, Hewitt, JK, Hopfer, CJ, Iacono, WG, Johnson, EO, Karpyak, VM, Kendler, KS, Kranzler, HR, Krauter, K, Lind, PA, McGue, M, MacKillop, J, Madden, PAF, Maes, HH, Magnusson, PKE, Nelson, EC, Nöthen, MM, Palmer, AA, Penninx, BWJH, Porjesz, B, Rice, JP, Rietschel, M, Riley, BP, Rose, RJ, Shen, PH, Silberg, J, Stallings, MC, Tarter, RE, Vanyukov, MM, Vrieze, S, Wall, TL, Whitfield, JB, Zhao, H, Neale, BM, Wade, TD, Heath, AC, Montgomery, GW, Martin, NG, Sullivan, PF, Kaprio, J, Breen, G, Gelernter, J, Edenberg, HJ, Bulik, CM & Agrawal, A 2020, '
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies',
Addiction Biology (Online), bind 26, nr. 1, e12880.
https://doi.org/10.1111/adb.12880APA
Munn-Chernoff, M. A., Johnson, E. C., Chou, Y. L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., Yilmaz, Z., Baker, J. H., Hübel, C., Gordon, S., Medland, S. E., Watson, H. J., Gaspar, H. A., Bryois, J., Hinney, A., Leppä, V. M., Mattheisen, M., Ripke, S., Yao, S., ... Agrawal, A. (2020).
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Addiction Biology (Online),
26(1), [e12880].
https://doi.org/10.1111/adb.12880Vancouver
Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK o.a.
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Addiction Biology (Online). 2020;26(1). e12880.
https://doi.org/10.1111/adb.12880Author
Munn-Chernoff, Melissa A. ; Johnson, Emma C. ; Chou, Yi Ling ; Coleman, Jonathan R.I. ; Thornton, Laura M. ; Walters, Raymond K. ; Yilmaz, Zeynep ; Baker, Jessica H. ; Hübel, Christopher ; Gordon, Scott ; Medland, Sarah E. ; Watson, Hunna J. ; Gaspar, Héléna A. ; Bryois, Julien ; Hinney, Anke ; Leppä, Virpi M. ; Mattheisen, Manuel ; Ripke, Stephan ; Yao, Shuyang ; Giusti-Rodríguez, Paola ; Hanscombe, Ken B. ; Adan, Roger A.H. ; Alfredsson, Lars ; Ando, Tetsuya ; Andreassen, Ole A. ; Berrettini, Wade H. ; Boehm, Ilka ; Boni, Claudette ; Boraska Perica, Vesna ; Buehren, Katharina ; Burghardt, Roland ; Cassina, Matteo ; Cichon, Sven ; Clementi, Maurizio ; Cone, Roger D. ; Courtet, Philippe ; Crow, Scott ; Crowley, James J. ; Danner, Unna N. ; Davis, Oliver S.P. ; de Zwaan, Martina ; Dedoussis, George ; Degortes, Daniela ; DeSocio, Janiece E. ; Dick, Danielle M. ; Dikeos, Dimitris ; Dina, Christian ; Dmitrzak-Weglarz, Monika ; Docampo, Elisa ; Duncan, Laramie E. ; Egberts, Karin ; Ehrlich, Stefan ; Escaramís, Geòrgia ; Esko, Tõnu ; Estivill, Xavier ; Farmer, Anne ; Favaro, Angela ; Fernández-Aranda, Fernando ; Fichter, Manfred M. ; Fischer, Krista ; Föcker, Manuel ; Foretova, Lenka ; Forstner, Andreas J. ; Forzan, Monica ; Franklin, Christopher S. ; Gallinger, Steven ; Giegling, Ina ; Giuranna, Johanna ; Gonidakis, Fragiskos ; Gorwood, Philip ; Gratacos Mayora, Monica ; Guillaume, Sébastien ; Guo, Yiran ; Hakonarson, Hakon ; Hatzikotoulas, Konstantinos ; Hauser, Joanna ; Hebebrand, Johannes ; Helder, Sietske G. ; Herms, Stefan ; Herpertz-Dahlmann, Beate ; Herzog, Wolfgang ; Huckins, Laura M. ; Hudson, James I. ; Imgart, Hartmut ; Inoko, Hidetoshi ; Janout, Vladimir ; Jiménez-Murcia, Susana ; Julià, Antonio ; Kalsi, Gursharan ; Kaminská, Deborah ; Karhunen, Leila ; Karwautz, Andreas ; Kas, Martien J.H. ; Kennedy, James L. ; Keski-Rahkonen, Anna ; Kiezebrink, Kirsty ; Kim, Youl Ri ; Klump, Kelly L. ; Knudsen, Gun Peggy S. ; La Via, Maria C. ; Le Hellard, Stephanie ; Levitan, Robert D. ; Li, Dong ; Lilenfeld, Lisa ; Lin, Bochao Danae ; Lissowska, Jolanta ; Luykx, Jurjen ; Magistretti, Pierre J. ; Maj, Mario ; Mannik, Katrin ; Marsal, Sara ; Marshall, Christian R. ; Mattingsdal, Morten ; McDevitt, Sara ; McGuffin, Peter ; Metspalu, Andres ; Meulenbelt, Ingrid ; Micali, Nadia ; Mitchell, Karen ; Monteleone, Alessio Maria ; Monteleone, Palmiero ; Nacmias, Benedetta ; Navratilova, Marie ; Ntalla, Ioanna ; O'Toole, Julie K. ; Ophoff, Roel A. ; Padyukov, Leonid ; Palotie, Aarno ; Pantel, Jacques ; Papezova, Hana ; Pinto, Dalila ; Rabionet, Raquel ; Raevuori, Anu ; Ramoz, Nicolas ; Reichborn-Kjennerud, Ted ; Ricca, Valdo ; Ripatti, Samuli ; Ritschel, Franziska ; Roberts, Marion ; Rotondo, Alessandro ; Rujescu, Dan ; Rybakowski, Filip ; Santonastaso, Paolo ; Scherag, André ; Scherer, Stephen W. ; Schmidt, Ulrike ; Schork, Nicholas J. ; Schosser, Alexandra ; Seitz, Jochen ; Slachtova, Lenka ; Slagboom, P. Eline ; Slof-Op't Landt, Margarita C.T. ; Slopien, Agnieszka ; Sorbi, Sandro ; Świątkowska, Beata ; Szatkiewicz, Jin P. ; Tachmazidou, Ioanna ; Tenconi, Elena ; Tortorella, Alfonso ; Tozzi, Federica ; Treasure, Janet ; Tsitsika, Artemis ; Tyszkiewicz-Nwafor, Marta ; Tziouvas, Konstantinos ; van Elburg, Annemarie A. ; van Furth, Eric F. ; Wagner, Gudrun ; Walton, Esther ; Widen, Elisabeth ; Zeggini, Eleftheria ; Zerwas, Stephanie ; Zipfel, Stephan ; Bergen, Andrew W. ; Boden, Joseph M. ; Brandt, Harry ; Crawford, Steven ; Halmi, Katherine A. ; Horwood, L. John ; Johnson, Craig ; Kaplan, Allan S. ; Kaye, Walter H. ; Mitchell, James ; Olsen, Catherine M. ; Pearson, John F. ; Pedersen, Nancy L. ; Strober, Michael ; Werge, Thomas ; Whiteman, David C. ; Woodside, D. Blake ; Grove, Jakob ; Henders, Anjali K. ; Larsen, Janne T. ; Parker, Richard ; Petersen, Liselotte V. ; Jordan, Jennifer ; Kennedy, Martin A. ; Birgegård, Andreas ; Lichtenstein, Paul ; Norring, Claes ; Landén, Mikael ; Mortensen, Preben Bo ; Polimanti, Renato ; McClintick, Jeanette N. ; Adkins, Amy E. ; Aliev, Fazil ; Bacanu, Silviu Alin ; Batzler, Anthony ; Bertelsen, Sarah ; Biernacka, Joanna M. ; Bigdeli, Tim B. ; Chen, Li Shiun ; Clarke, Toni Kim ; Degenhardt, Franziska ; Docherty, Anna R. ; Edwards, Alexis C. ; Foo, Jerome C. ; Fox, Louis ; Frank, Josef ; Hack, Laura M. ; Hartmann, Annette M. ; Hartz, Sarah M. ; Heilmann-Heimbach, Stefanie ; Hodgkinson, Colin ; Hoffmann, Per ; Hottenga, Jouke Jan ; Konte, Bettina ; Lahti, Jari ; Lahti-Pulkkinen, Marius ; Lai, Dongbing ; Ligthart, Lannie ; Loukola, Anu ; Maher, Brion S. ; Mbarek, Hamdi ; McIntosh, Andrew M. ; McQueen, Matthew B. ; Meyers, Jacquelyn L. ; Milaneschi, Yuri ; Palviainen, Teemu ; Peterson, Roseann E. ; Ryu, Euijung ; Saccone, Nancy L. ; Salvatore, Jessica E. ; Sanchez-Roige, Sandra ; Schwandt, Melanie ; Sherva, Richard ; Streit, Fabian ; Strohmaier, Jana ; Thomas, Nathaniel ; Wang, Jen Chyong ; Webb, Bradley T. ; Wedow, Robbee ; Wetherill, Leah ; Wills, Amanda G. ; Zhou, Hang ; Boardman, Jason D. ; Chen, Danfeng ; Choi, Doo Sup ; Copeland, William E. ; Culverhouse, Robert C. ; Dahmen, Norbert ; Degenhardt, Louisa ; Domingue, Benjamin W. ; Frye, Mark A. ; Gäbel, Wolfgang ; Hayward, Caroline ; Ising, Marcus ; Keyes, Margaret ; Kiefer, Falk ; Koller, Gabriele ; Kramer, John ; Kuperman, Samuel ; Lucae, Susanne ; Lynskey, Michael T. ; Maier, Wolfgang ; Mann, Karl ; Männistö, Satu ; Müller-Myhsok, Bertram ; Murray, Alison D. ; Nurnberger, John I. ; Preuss, Ulrich ; Räikkönen, Katri ; Reynolds, Maureen D. ; Ridinger, Monika ; Scherbaum, Norbert ; Schuckit, Marc A. ; Soyka, Michael ; Treutlein, Jens ; Witt, Stephanie H. ; Wodarz, Norbert ; Zill, Peter ; Adkins, Daniel E. ; Boomsma, Dorret I. ; Bierut, Laura J. ; Brown, Sandra A. ; Bucholz, Kathleen K. ; Costello, E. Jane ; de Wit, Harriet ; Diazgranados, Nancy ; Eriksson, Johan G. ; Farrer, Lindsay A. ; Foroud, Tatiana M. ; Gillespie, Nathan A. ; Goate, Alison M. ; Goldman, David ; Grucza, Richard A. ; Hancock, Dana B. ; Harris, Kathleen Mullan ; Hesselbrock, Victor ; Hewitt, John K. ; Hopfer, Christian J. ; Iacono, William G. ; Johnson, Eric O. ; Karpyak, Victor M. ; Kendler, Kenneth S. ; Kranzler, Henry R. ; Krauter, Kenneth ; Lind, Penelope A. ; McGue, Matt ; MacKillop, James ; Madden, Pamela A.F. ; Maes, Hermine H. ; Magnusson, Patrik K.E. ; Nelson, Elliot C. ; Nöthen, Markus M. ; Palmer, Abraham A. ; Penninx, Brenda W.J.H. ; Porjesz, Bernice ; Rice, John P. ; Rietschel, Marcella ; Riley, Brien P. ; Rose, Richard J. ; Shen, Pei Hong ; Silberg, Judy ; Stallings, Michael C. ; Tarter, Ralph E. ; Vanyukov, Michael M. ; Vrieze, Scott ; Wall, Tamara L. ; Whitfield, John B. ; Zhao, Hongyu ; Neale, Benjamin M. ; Wade, Tracey D. ; Heath, Andrew C. ; Montgomery, Grant W. ; Martin, Nicholas G. ; Sullivan, Patrick F. ; Kaprio, Jaakko ; Breen, Gerome ; Gelernter, Joel ; Edenberg, Howard J. ; Bulik, Cynthia M. ; Agrawal, Arpana. / Shared genetic risk between eating disorder- and substance-use-related phenotypes : Evidence from genome-wide association studies. I: Addiction Biology (Online). 2020 ; Bind 26, Nr. 1.
Bibtex
@article{e1abefb418f94ea9b1f77a42661e9deb,
title = "Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies",
abstract = "Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.",
keywords = "eating disorders, genetic correlation, substance use",
author = "Munn-Chernoff, {Melissa A.} and Johnson, {Emma C.} and Chou, {Yi Ling} and Coleman, {Jonathan R.I.} and Thornton, {Laura M.} and Walters, {Raymond K.} and Zeynep Yilmaz and Baker, {Jessica H.} and Christopher H{\"u}bel and Scott Gordon and Medland, {Sarah E.} and Watson, {Hunna J.} and Gaspar, {H{\'e}l{\'e}na A.} and Julien Bryois and Anke Hinney and Lepp{\"a}, {Virpi M.} and Manuel Mattheisen and Stephan Ripke and Shuyang Yao and Paola Giusti-Rodr{\'i}guez and Hanscombe, {Ken B.} and Adan, {Roger A.H.} and Lars Alfredsson and Tetsuya Ando and Andreassen, {Ole A.} and Berrettini, {Wade H.} and Ilka Boehm and Claudette Boni and {Boraska Perica}, Vesna and Katharina Buehren and Roland Burghardt and Matteo Cassina and Sven Cichon and Maurizio Clementi and Cone, {Roger D.} and Philippe Courtet and Scott Crow and Crowley, {James J.} and Danner, {Unna N.} and Davis, {Oliver S.P.} and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and DeSocio, {Janiece E.} and Dick, {Danielle M.} and Dimitris Dikeos and Christian Dina and Monika Dmitrzak-Weglarz and Elisa Docampo and Duncan, {Laramie E.} and Karin Egberts and Stefan Ehrlich and Ge{\`o}rgia Escaram{\'i}s and T{\~o}nu Esko and Xavier Estivill and Anne Farmer and Angela Favaro and Fernando Fern{\'a}ndez-Aranda and Fichter, {Manfred M.} and Krista Fischer and Manuel F{\"o}cker and Lenka Foretova and Forstner, {Andreas J.} and Monica Forzan and Franklin, {Christopher S.} and Steven Gallinger and Ina Giegling and Johanna Giuranna and Fragiskos Gonidakis and Philip Gorwood and {Gratacos Mayora}, Monica and S{\'e}bastien Guillaume and Yiran Guo and Hakon Hakonarson and Konstantinos Hatzikotoulas and Joanna Hauser and Johannes Hebebrand and Helder, {Sietske G.} and Stefan Herms and Beate Herpertz-Dahlmann and Wolfgang Herzog and Huckins, {Laura M.} and Hudson, {James I.} and Hartmut Imgart and Hidetoshi Inoko and Vladimir Janout and Susana Jim{\'e}nez-Murcia and Antonio Juli{\`a} and Gursharan Kalsi and Deborah Kaminsk{\'a} and Leila Karhunen and Andreas Karwautz and Kas, {Martien J.H.} and Kennedy, {James L.} and Anna Keski-Rahkonen and Kirsty Kiezebrink and Kim, {Youl Ri} and Klump, {Kelly L.} and Knudsen, {Gun Peggy S.} and {La Via}, {Maria C.} and {Le Hellard}, Stephanie and Levitan, {Robert D.} and Dong Li and Lisa Lilenfeld and Lin, {Bochao Danae} and Jolanta Lissowska and Jurjen Luykx and Magistretti, {Pierre J.} and Mario Maj and Katrin Mannik and Sara Marsal and Marshall, {Christian R.} and Morten Mattingsdal and Sara McDevitt and Peter McGuffin and Andres Metspalu and Ingrid Meulenbelt and Nadia Micali and Karen Mitchell and Monteleone, {Alessio Maria} and Palmiero Monteleone and Benedetta Nacmias and Marie Navratilova and Ioanna Ntalla and O'Toole, {Julie K.} and Ophoff, {Roel A.} and Leonid Padyukov and Aarno Palotie and Jacques Pantel and Hana Papezova and Dalila Pinto and Raquel Rabionet and Anu Raevuori and Nicolas Ramoz and Ted Reichborn-Kjennerud and Valdo Ricca and Samuli Ripatti and Franziska Ritschel and Marion Roberts and Alessandro Rotondo and Dan Rujescu and Filip Rybakowski and Paolo Santonastaso and Andr{\'e} Scherag and Scherer, {Stephen W.} and Ulrike Schmidt and Schork, {Nicholas J.} and Alexandra Schosser and Jochen Seitz and Lenka Slachtova and Slagboom, {P. Eline} and {Slof-Op't Landt}, {Margarita C.T.} and Agnieszka Slopien and Sandro Sorbi and Beata {\'S}wi{\c a}tkowska and Szatkiewicz, {Jin P.} and Ioanna Tachmazidou and Elena Tenconi and Alfonso Tortorella and Federica Tozzi and Janet Treasure and Artemis Tsitsika and Marta Tyszkiewicz-Nwafor and Konstantinos Tziouvas and {van Elburg}, {Annemarie A.} and {van Furth}, {Eric F.} and Gudrun Wagner and Esther Walton and Elisabeth Widen and Eleftheria Zeggini and Stephanie Zerwas and Stephan Zipfel and Bergen, {Andrew W.} and Boden, {Joseph M.} and Harry Brandt and Steven Crawford and Halmi, {Katherine A.} and Horwood, {L. John} and Craig Johnson and Kaplan, {Allan S.} and Kaye, {Walter H.} and James Mitchell and Olsen, {Catherine M.} and Pearson, {John F.} and Pedersen, {Nancy L.} and Michael Strober and Thomas Werge and Whiteman, {David C.} and Woodside, {D. Blake} and Jakob Grove and Henders, {Anjali K.} and Larsen, {Janne T.} and Richard Parker and Petersen, {Liselotte V.} and Jennifer Jordan and Kennedy, {Martin A.} and Andreas Birgeg{\aa}rd and Paul Lichtenstein and Claes Norring and Mikael Land{\'e}n and Mortensen, {Preben Bo} and Renato Polimanti and McClintick, {Jeanette N.} and Adkins, {Amy E.} and Fazil Aliev and Bacanu, {Silviu Alin} and Anthony Batzler and Sarah Bertelsen and Biernacka, {Joanna M.} and Bigdeli, {Tim B.} and Chen, {Li Shiun} and Clarke, {Toni Kim} and Franziska Degenhardt and Docherty, {Anna R.} and Edwards, {Alexis C.} and Foo, {Jerome C.} and Louis Fox and Josef Frank and Hack, {Laura M.} and Hartmann, {Annette M.} and Hartz, {Sarah M.} and Stefanie Heilmann-Heimbach and Colin Hodgkinson and Per Hoffmann and Hottenga, {Jouke Jan} and Bettina Konte and Jari Lahti and Marius Lahti-Pulkkinen and Dongbing Lai and Lannie Ligthart and Anu Loukola and Maher, {Brion S.} and Hamdi Mbarek and McIntosh, {Andrew M.} and McQueen, {Matthew B.} and Meyers, {Jacquelyn L.} and Yuri Milaneschi and Teemu Palviainen and Peterson, {Roseann E.} and Euijung Ryu and Saccone, {Nancy L.} and Salvatore, {Jessica E.} and Sandra Sanchez-Roige and Melanie Schwandt and Richard Sherva and Fabian Streit and Jana Strohmaier and Nathaniel Thomas and Wang, {Jen Chyong} and Webb, {Bradley T.} and Robbee Wedow and Leah Wetherill and Wills, {Amanda G.} and Hang Zhou and Boardman, {Jason D.} and Danfeng Chen and Choi, {Doo Sup} and Copeland, {William E.} and Culverhouse, {Robert C.} and Norbert Dahmen and Louisa Degenhardt and Domingue, {Benjamin W.} and Frye, {Mark A.} and Wolfgang G{\"a}bel and Caroline Hayward and Marcus Ising and Margaret Keyes and Falk Kiefer and Gabriele Koller and John Kramer and Samuel Kuperman and Susanne Lucae and Lynskey, {Michael T.} and Wolfgang Maier and Karl Mann and Satu M{\"a}nnist{\"o} and Bertram M{\"u}ller-Myhsok and Murray, {Alison D.} and Nurnberger, {John I.} and Ulrich Preuss and Katri R{\"a}ikk{\"o}nen and Reynolds, {Maureen D.} and Monika Ridinger and Norbert Scherbaum and Schuckit, {Marc A.} and Michael Soyka and Jens Treutlein and Witt, {Stephanie H.} and Norbert Wodarz and Peter Zill and Adkins, {Daniel E.} and Boomsma, {Dorret I.} and Bierut, {Laura J.} and Brown, {Sandra A.} and Bucholz, {Kathleen K.} and Costello, {E. Jane} and {de Wit}, Harriet and Nancy Diazgranados and Eriksson, {Johan G.} and Farrer, {Lindsay A.} and Foroud, {Tatiana M.} and Gillespie, {Nathan A.} and Goate, {Alison M.} and David Goldman and Grucza, {Richard A.} and Hancock, {Dana B.} and Harris, {Kathleen Mullan} and Victor Hesselbrock and Hewitt, {John K.} and Hopfer, {Christian J.} and Iacono, {William G.} and Johnson, {Eric O.} and Karpyak, {Victor M.} and Kendler, {Kenneth S.} and Kranzler, {Henry R.} and Kenneth Krauter and Lind, {Penelope A.} and Matt McGue and James MacKillop and Madden, {Pamela A.F.} and Maes, {Hermine H.} and Magnusson, {Patrik K.E.} and Nelson, {Elliot C.} and N{\"o}then, {Markus M.} and Palmer, {Abraham A.} and Penninx, {Brenda W.J.H.} and Bernice Porjesz and Rice, {John P.} and Marcella Rietschel and Riley, {Brien P.} and Rose, {Richard J.} and Shen, {Pei Hong} and Judy Silberg and Stallings, {Michael C.} and Tarter, {Ralph E.} and Vanyukov, {Michael M.} and Scott Vrieze and Wall, {Tamara L.} and Whitfield, {John B.} and Hongyu Zhao and Neale, {Benjamin M.} and Wade, {Tracey D.} and Heath, {Andrew C.} and Montgomery, {Grant W.} and Martin, {Nicholas G.} and Sullivan, {Patrick F.} and Jaakko Kaprio and Gerome Breen and Joel Gelernter and Edenberg, {Howard J.} and Bulik, {Cynthia M.} and Arpana Agrawal",
year = "2020",
doi = "10.1111/adb.12880",
language = "English",
volume = "26",
journal = "Addiction Biology (Online)",
issn = "1369-1600",
publisher = "Wiley-Blackwell",
number = "1",
}
RIS
TY - JOUR
T1 - Shared genetic risk between eating disorder- and substance-use-related phenotypes
T2 - Evidence from genome-wide association studies
AU - Munn-Chernoff, Melissa A.
AU - Johnson, Emma C.
AU - Chou, Yi Ling
AU - Coleman, Jonathan R.I.
AU - Thornton, Laura M.
AU - Walters, Raymond K.
AU - Yilmaz, Zeynep
AU - Baker, Jessica H.
AU - Hübel, Christopher
AU - Gordon, Scott
AU - Medland, Sarah E.
AU - Watson, Hunna J.
AU - Gaspar, Héléna A.
AU - Bryois, Julien
AU - Hinney, Anke
AU - Leppä, Virpi M.
AU - Mattheisen, Manuel
AU - Ripke, Stephan
AU - Yao, Shuyang
AU - Giusti-Rodríguez, Paola
AU - Hanscombe, Ken B.
AU - Adan, Roger A.H.
AU - Alfredsson, Lars
AU - Ando, Tetsuya
AU - Andreassen, Ole A.
AU - Berrettini, Wade H.
AU - Boehm, Ilka
AU - Boni, Claudette
AU - Boraska Perica, Vesna
AU - Buehren, Katharina
AU - Burghardt, Roland
AU - Cassina, Matteo
AU - Cichon, Sven
AU - Clementi, Maurizio
AU - Cone, Roger D.
AU - Courtet, Philippe
AU - Crow, Scott
AU - Crowley, James J.
AU - Danner, Unna N.
AU - Davis, Oliver S.P.
AU - de Zwaan, Martina
AU - Dedoussis, George
AU - Degortes, Daniela
AU - DeSocio, Janiece E.
AU - Dick, Danielle M.
AU - Dikeos, Dimitris
AU - Dina, Christian
AU - Dmitrzak-Weglarz, Monika
AU - Docampo, Elisa
AU - Duncan, Laramie E.
AU - Egberts, Karin
AU - Ehrlich, Stefan
AU - Escaramís, Geòrgia
AU - Esko, Tõnu
AU - Estivill, Xavier
AU - Farmer, Anne
AU - Favaro, Angela
AU - Fernández-Aranda, Fernando
AU - Fichter, Manfred M.
AU - Fischer, Krista
AU - Föcker, Manuel
AU - Foretova, Lenka
AU - Forstner, Andreas J.
AU - Forzan, Monica
AU - Franklin, Christopher S.
AU - Gallinger, Steven
AU - Giegling, Ina
AU - Giuranna, Johanna
AU - Gonidakis, Fragiskos
AU - Gorwood, Philip
AU - Gratacos Mayora, Monica
AU - Guillaume, Sébastien
AU - Guo, Yiran
AU - Hakonarson, Hakon
AU - Hatzikotoulas, Konstantinos
AU - Hauser, Joanna
AU - Hebebrand, Johannes
AU - Helder, Sietske G.
AU - Herms, Stefan
AU - Herpertz-Dahlmann, Beate
AU - Herzog, Wolfgang
AU - Huckins, Laura M.
AU - Hudson, James I.
AU - Imgart, Hartmut
AU - Inoko, Hidetoshi
AU - Janout, Vladimir
AU - Jiménez-Murcia, Susana
AU - Julià, Antonio
AU - Kalsi, Gursharan
AU - Kaminská, Deborah
AU - Karhunen, Leila
AU - Karwautz, Andreas
AU - Kas, Martien J.H.
AU - Kennedy, James L.
AU - Keski-Rahkonen, Anna
AU - Kiezebrink, Kirsty
AU - Kim, Youl Ri
AU - Klump, Kelly L.
AU - Knudsen, Gun Peggy S.
AU - La Via, Maria C.
AU - Le Hellard, Stephanie
AU - Levitan, Robert D.
AU - Li, Dong
AU - Lilenfeld, Lisa
AU - Lin, Bochao Danae
AU - Lissowska, Jolanta
AU - Luykx, Jurjen
AU - Magistretti, Pierre J.
AU - Maj, Mario
AU - Mannik, Katrin
AU - Marsal, Sara
AU - Marshall, Christian R.
AU - Mattingsdal, Morten
AU - McDevitt, Sara
AU - McGuffin, Peter
AU - Metspalu, Andres
AU - Meulenbelt, Ingrid
AU - Micali, Nadia
AU - Mitchell, Karen
AU - Monteleone, Alessio Maria
AU - Monteleone, Palmiero
AU - Nacmias, Benedetta
AU - Navratilova, Marie
AU - Ntalla, Ioanna
AU - O'Toole, Julie K.
AU - Ophoff, Roel A.
AU - Padyukov, Leonid
AU - Palotie, Aarno
AU - Pantel, Jacques
AU - Papezova, Hana
AU - Pinto, Dalila
AU - Rabionet, Raquel
AU - Raevuori, Anu
AU - Ramoz, Nicolas
AU - Reichborn-Kjennerud, Ted
AU - Ricca, Valdo
AU - Ripatti, Samuli
AU - Ritschel, Franziska
AU - Roberts, Marion
AU - Rotondo, Alessandro
AU - Rujescu, Dan
AU - Rybakowski, Filip
AU - Santonastaso, Paolo
AU - Scherag, André
AU - Scherer, Stephen W.
AU - Schmidt, Ulrike
AU - Schork, Nicholas J.
AU - Schosser, Alexandra
AU - Seitz, Jochen
AU - Slachtova, Lenka
AU - Slagboom, P. Eline
AU - Slof-Op't Landt, Margarita C.T.
AU - Slopien, Agnieszka
AU - Sorbi, Sandro
AU - Świątkowska, Beata
AU - Szatkiewicz, Jin P.
AU - Tachmazidou, Ioanna
AU - Tenconi, Elena
AU - Tortorella, Alfonso
AU - Tozzi, Federica
AU - Treasure, Janet
AU - Tsitsika, Artemis
AU - Tyszkiewicz-Nwafor, Marta
AU - Tziouvas, Konstantinos
AU - van Elburg, Annemarie A.
AU - van Furth, Eric F.
AU - Wagner, Gudrun
AU - Walton, Esther
AU - Widen, Elisabeth
AU - Zeggini, Eleftheria
AU - Zerwas, Stephanie
AU - Zipfel, Stephan
AU - Bergen, Andrew W.
AU - Boden, Joseph M.
AU - Brandt, Harry
AU - Crawford, Steven
AU - Halmi, Katherine A.
AU - Horwood, L. John
AU - Johnson, Craig
AU - Kaplan, Allan S.
AU - Kaye, Walter H.
AU - Mitchell, James
AU - Olsen, Catherine M.
AU - Pearson, John F.
AU - Pedersen, Nancy L.
AU - Strober, Michael
AU - Werge, Thomas
AU - Whiteman, David C.
AU - Woodside, D. Blake
AU - Grove, Jakob
AU - Henders, Anjali K.
AU - Larsen, Janne T.
AU - Parker, Richard
AU - Petersen, Liselotte V.
AU - Jordan, Jennifer
AU - Kennedy, Martin A.
AU - Birgegård, Andreas
AU - Lichtenstein, Paul
AU - Norring, Claes
AU - Landén, Mikael
AU - Mortensen, Preben Bo
AU - Polimanti, Renato
AU - McClintick, Jeanette N.
AU - Adkins, Amy E.
AU - Aliev, Fazil
AU - Bacanu, Silviu Alin
AU - Batzler, Anthony
AU - Bertelsen, Sarah
AU - Biernacka, Joanna M.
AU - Bigdeli, Tim B.
AU - Chen, Li Shiun
AU - Clarke, Toni Kim
AU - Degenhardt, Franziska
AU - Docherty, Anna R.
AU - Edwards, Alexis C.
AU - Foo, Jerome C.
AU - Fox, Louis
AU - Frank, Josef
AU - Hack, Laura M.
AU - Hartmann, Annette M.
AU - Hartz, Sarah M.
AU - Heilmann-Heimbach, Stefanie
AU - Hodgkinson, Colin
AU - Hoffmann, Per
AU - Hottenga, Jouke Jan
AU - Konte, Bettina
AU - Lahti, Jari
AU - Lahti-Pulkkinen, Marius
AU - Lai, Dongbing
AU - Ligthart, Lannie
AU - Loukola, Anu
AU - Maher, Brion S.
AU - Mbarek, Hamdi
AU - McIntosh, Andrew M.
AU - McQueen, Matthew B.
AU - Meyers, Jacquelyn L.
AU - Milaneschi, Yuri
AU - Palviainen, Teemu
AU - Peterson, Roseann E.
AU - Ryu, Euijung
AU - Saccone, Nancy L.
AU - Salvatore, Jessica E.
AU - Sanchez-Roige, Sandra
AU - Schwandt, Melanie
AU - Sherva, Richard
AU - Streit, Fabian
AU - Strohmaier, Jana
AU - Thomas, Nathaniel
AU - Wang, Jen Chyong
AU - Webb, Bradley T.
AU - Wedow, Robbee
AU - Wetherill, Leah
AU - Wills, Amanda G.
AU - Zhou, Hang
AU - Boardman, Jason D.
AU - Chen, Danfeng
AU - Choi, Doo Sup
AU - Copeland, William E.
AU - Culverhouse, Robert C.
AU - Dahmen, Norbert
AU - Degenhardt, Louisa
AU - Domingue, Benjamin W.
AU - Frye, Mark A.
AU - Gäbel, Wolfgang
AU - Hayward, Caroline
AU - Ising, Marcus
AU - Keyes, Margaret
AU - Kiefer, Falk
AU - Koller, Gabriele
AU - Kramer, John
AU - Kuperman, Samuel
AU - Lucae, Susanne
AU - Lynskey, Michael T.
AU - Maier, Wolfgang
AU - Mann, Karl
AU - Männistö, Satu
AU - Müller-Myhsok, Bertram
AU - Murray, Alison D.
AU - Nurnberger, John I.
AU - Preuss, Ulrich
AU - Räikkönen, Katri
AU - Reynolds, Maureen D.
AU - Ridinger, Monika
AU - Scherbaum, Norbert
AU - Schuckit, Marc A.
AU - Soyka, Michael
AU - Treutlein, Jens
AU - Witt, Stephanie H.
AU - Wodarz, Norbert
AU - Zill, Peter
AU - Adkins, Daniel E.
AU - Boomsma, Dorret I.
AU - Bierut, Laura J.
AU - Brown, Sandra A.
AU - Bucholz, Kathleen K.
AU - Costello, E. Jane
AU - de Wit, Harriet
AU - Diazgranados, Nancy
AU - Eriksson, Johan G.
AU - Farrer, Lindsay A.
AU - Foroud, Tatiana M.
AU - Gillespie, Nathan A.
AU - Goate, Alison M.
AU - Goldman, David
AU - Grucza, Richard A.
AU - Hancock, Dana B.
AU - Harris, Kathleen Mullan
AU - Hesselbrock, Victor
AU - Hewitt, John K.
AU - Hopfer, Christian J.
AU - Iacono, William G.
AU - Johnson, Eric O.
AU - Karpyak, Victor M.
AU - Kendler, Kenneth S.
AU - Kranzler, Henry R.
AU - Krauter, Kenneth
AU - Lind, Penelope A.
AU - McGue, Matt
AU - MacKillop, James
AU - Madden, Pamela A.F.
AU - Maes, Hermine H.
AU - Magnusson, Patrik K.E.
AU - Nelson, Elliot C.
AU - Nöthen, Markus M.
AU - Palmer, Abraham A.
AU - Penninx, Brenda W.J.H.
AU - Porjesz, Bernice
AU - Rice, John P.
AU - Rietschel, Marcella
AU - Riley, Brien P.
AU - Rose, Richard J.
AU - Shen, Pei Hong
AU - Silberg, Judy
AU - Stallings, Michael C.
AU - Tarter, Ralph E.
AU - Vanyukov, Michael M.
AU - Vrieze, Scott
AU - Wall, Tamara L.
AU - Whitfield, John B.
AU - Zhao, Hongyu
AU - Neale, Benjamin M.
AU - Wade, Tracey D.
AU - Heath, Andrew C.
AU - Montgomery, Grant W.
AU - Martin, Nicholas G.
AU - Sullivan, Patrick F.
AU - Kaprio, Jaakko
AU - Breen, Gerome
AU - Gelernter, Joel
AU - Edenberg, Howard J.
AU - Bulik, Cynthia M.
AU - Agrawal, Arpana
PY - 2020
Y1 - 2020
N2 - Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
AB - Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
KW - eating disorders
KW - genetic correlation
KW - substance use
U2 - 10.1111/adb.12880
DO - 10.1111/adb.12880
M3 - Journal article
C2 - 32064741
AN - SCOPUS:85079714981
VL - 26
JO - Addiction Biology (Online)
JF - Addiction Biology (Online)
SN - 1369-1600
IS - 1
M1 - e12880
ER -
