Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles. / Meisinger, Christa; Ittermann, Till; Tiller, Daniel; Agger, Carsten; Nauck, Matthias; Schipf, Sabine; Wallaschofski, Henri; Jørgensen, Torben; Linneberg, Allan; Thiery, Joachim; Kluttig, Alexander; Greiser, Karin H; Werdan, Karl; Burkhardt, Katrin; Völzke, Henry.
I: Thyroid, Bind 24, Nr. 3, 03.2014, s. 424-432.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles
AU - Meisinger, Christa
AU - Ittermann, Till
AU - Tiller, Daniel
AU - Agger, Carsten
AU - Nauck, Matthias
AU - Schipf, Sabine
AU - Wallaschofski, Henri
AU - Jørgensen, Torben
AU - Linneberg, Allan
AU - Thiery, Joachim
AU - Kluttig, Alexander
AU - Greiser, Karin H
AU - Werdan, Karl
AU - Burkhardt, Katrin
AU - Völzke, Henry
PY - 2014/3
Y1 - 2014/3
N2 - BACKGROUND: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied.METHODS: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models.RESULTS: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (<3.0 mIU/L) were significantly associated with lower total cholesterol, while high serum TSH levels (≥ 3.0 mIU/L) were associated with higher triglyceride values. In the pooled female population, low serum TSH levels were significantly associated with lower total cholesterol, LDL cholesterol, and HDL cholesterol. High TSH levels were associated with higher total cholesterol and LDL cholesterol in the pooled female population. In both sexes, serum TSH levels within the reference range (0.3-3.0 mIU/L) were significantly positively associated with triglyceride concentrations.CONCLUSIONS: Increasing levels of TSH were associated with a less favorable lipid profile in both men and women from the general population. In both sexes, TSH levels within the reference range were significantly positively associated with triglyceride concentrations.
AB - BACKGROUND: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied.METHODS: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models.RESULTS: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (<3.0 mIU/L) were significantly associated with lower total cholesterol, while high serum TSH levels (≥ 3.0 mIU/L) were associated with higher triglyceride values. In the pooled female population, low serum TSH levels were significantly associated with lower total cholesterol, LDL cholesterol, and HDL cholesterol. High TSH levels were associated with higher total cholesterol and LDL cholesterol in the pooled female population. In both sexes, serum TSH levels within the reference range (0.3-3.0 mIU/L) were significantly positively associated with triglyceride concentrations.CONCLUSIONS: Increasing levels of TSH were associated with a less favorable lipid profile in both men and women from the general population. In both sexes, TSH levels within the reference range were significantly positively associated with triglyceride concentrations.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cross-Sectional Studies
KW - European Continental Ancestry Group
KW - Female
KW - Humans
KW - Lipids
KW - Male
KW - Middle Aged
KW - Reference Values
KW - Thyrotropin
KW - Young Adult
U2 - 10.1089/thy.2013.0259
DO - 10.1089/thy.2013.0259
M3 - Journal article
C2 - 24102572
VL - 24
SP - 424
EP - 432
JO - Thyroid
JF - Thyroid
SN - 1050-7256
IS - 3
ER -
ID: 138725902