Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. / Wang, Xuewen; Magkos, Faidon; Mittendorfer, Bettina.
I: Journal of Clinical Endocrinology and Metabolism, Bind 96, Nr. 4, 2011, s. 885-893.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones
AU - Wang, Xuewen
AU - Magkos, Faidon
AU - Mittendorfer, Bettina
N1 - (Ekstern)
PY - 2011
Y1 - 2011
N2 - It is commonly thought that sex hormones are important regulators of plasma lipid kinetics and are responsible for sexual dimorphism in the plasma lipid profile. Here we discuss the findings from studies evaluating lipid and lipoprotein kinetics in men and women in the context of what we know about the effects of exogenous sex hormone administration, and we conclude that it is more complicated than that. It has become clear that normal physiological alterations in the hormonal milieu (i.e. due to menopause or throughout the menstrual cycle) do not significantly affect plasma lipid homeostasis. Furthermore, parenterally administered estrogens have either no effect or only very small beneficial effects, whereas orally administered estrogens raise plasma triglyceride concentrations--a phenomenon that is not consistent with the observed sex differences and likely results from the hepatic "first-pass effect." The effects of progestogens and androgens mimic only in part the differences in plasma lipids between men and women. Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated.
AB - It is commonly thought that sex hormones are important regulators of plasma lipid kinetics and are responsible for sexual dimorphism in the plasma lipid profile. Here we discuss the findings from studies evaluating lipid and lipoprotein kinetics in men and women in the context of what we know about the effects of exogenous sex hormone administration, and we conclude that it is more complicated than that. It has become clear that normal physiological alterations in the hormonal milieu (i.e. due to menopause or throughout the menstrual cycle) do not significantly affect plasma lipid homeostasis. Furthermore, parenterally administered estrogens have either no effect or only very small beneficial effects, whereas orally administered estrogens raise plasma triglyceride concentrations--a phenomenon that is not consistent with the observed sex differences and likely results from the hepatic "first-pass effect." The effects of progestogens and androgens mimic only in part the differences in plasma lipids between men and women. Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated.
KW - Confounding Factors, Epidemiologic
KW - Female
KW - Gonadal Steroid Hormones/administration & dosage
KW - Humans
KW - Kinetics
KW - Lipid Metabolism/drug effects
KW - Lipoproteins/metabolism
KW - Male
KW - Sex Characteristics
U2 - 10.1210/jc.2010-2061
DO - 10.1210/jc.2010-2061
M3 - Review
C2 - 21474685
VL - 96
SP - 885
EP - 893
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -
ID: 290458935