Serum cytokine levels in Kleine-Levin syndrome

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Serum cytokine levels in Kleine-Levin syndrome. / Kornum, Birgitte Rahbek; Rico, Thomas; Lin, Ling; Huang, Yu-Shu; Arnulf, Isabelle; Jennum, Poul; Mignot, Emmanuel.

I: Sleep Medicine, Bind 16, Nr. 8, 08.2015, s. 961-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kornum, BR, Rico, T, Lin, L, Huang, Y-S, Arnulf, I, Jennum, P & Mignot, E 2015, 'Serum cytokine levels in Kleine-Levin syndrome', Sleep Medicine, bind 16, nr. 8, s. 961-5. https://doi.org/10.1016/j.sleep.2015.02.540

APA

Kornum, B. R., Rico, T., Lin, L., Huang, Y-S., Arnulf, I., Jennum, P., & Mignot, E. (2015). Serum cytokine levels in Kleine-Levin syndrome. Sleep Medicine, 16(8), 961-5. https://doi.org/10.1016/j.sleep.2015.02.540

Vancouver

Kornum BR, Rico T, Lin L, Huang Y-S, Arnulf I, Jennum P o.a. Serum cytokine levels in Kleine-Levin syndrome. Sleep Medicine. 2015 aug.;16(8):961-5. https://doi.org/10.1016/j.sleep.2015.02.540

Author

Kornum, Birgitte Rahbek ; Rico, Thomas ; Lin, Ling ; Huang, Yu-Shu ; Arnulf, Isabelle ; Jennum, Poul ; Mignot, Emmanuel. / Serum cytokine levels in Kleine-Levin syndrome. I: Sleep Medicine. 2015 ; Bind 16, Nr. 8. s. 961-5.

Bibtex

@article{e7a14e4424d74c33ab2da9161e4c494c,

title = "Serum cytokine levels in Kleine-Levin syndrome",

abstract = "OBJECTIVE: Kleine-Levin Syndrome (KLS) is a rare sleep disorder causing recurrent symptomatic episodes of severe hypersomnia, cognitive impairment, apathy, and derealization. These episodes are interspersed with long periods of normal sleep, cognition, and behavior. The pathogenesis of KLS is still unknown. The objective of this study was to determine serum cytokine levels in patients with KLS during and between episodes.PATIENTS/METHODS: Fifty-two typical KLS patients were included in the study of whom 17 patients donated blood samples both during and between episodes. Blood samples were collected in USA, France, and Taiwan in a clinical setting. Processing of the samples was performed at the Stanford Center for Sleep Sciences and Medicine.RESULTS: We did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age- and gender matched healthy controls (n = 8/group) whose blood samples were all collected and processed at the same day; asymptomatic KLS patients had significantly higher levels of serum sVCAM1 cytokine compared to healthy controls.CONCLUSION: These data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.",

keywords = "Adolescent, Adult, Case-Control Studies, Chemokines, Cytokines, Female, Humans, Interleukins, Kleine-Levin Syndrome, Male, Middle Aged, Young Adult",

author = "Kornum, {Birgitte Rahbek} and Thomas Rico and Ling Lin and Yu-Shu Huang and Isabelle Arnulf and Poul Jennum and Emmanuel Mignot",

year = "2015",

month = aug,

doi = "10.1016/j.sleep.2015.02.540",

language = "English",

volume = "16",

pages = "961--5",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier",

number = "8",

}

RIS

TY - JOUR

T1 - Serum cytokine levels in Kleine-Levin syndrome

AU - Kornum, Birgitte Rahbek

AU - Rico, Thomas

AU - Lin, Ling

AU - Huang, Yu-Shu

AU - Arnulf, Isabelle

AU - Jennum, Poul

AU - Mignot, Emmanuel

PY - 2015/8

Y1 - 2015/8

N2 - OBJECTIVE: Kleine-Levin Syndrome (KLS) is a rare sleep disorder causing recurrent symptomatic episodes of severe hypersomnia, cognitive impairment, apathy, and derealization. These episodes are interspersed with long periods of normal sleep, cognition, and behavior. The pathogenesis of KLS is still unknown. The objective of this study was to determine serum cytokine levels in patients with KLS during and between episodes.PATIENTS/METHODS: Fifty-two typical KLS patients were included in the study of whom 17 patients donated blood samples both during and between episodes. Blood samples were collected in USA, France, and Taiwan in a clinical setting. Processing of the samples was performed at the Stanford Center for Sleep Sciences and Medicine.RESULTS: We did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age- and gender matched healthy controls (n = 8/group) whose blood samples were all collected and processed at the same day; asymptomatic KLS patients had significantly higher levels of serum sVCAM1 cytokine compared to healthy controls.CONCLUSION: These data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.

AB - OBJECTIVE: Kleine-Levin Syndrome (KLS) is a rare sleep disorder causing recurrent symptomatic episodes of severe hypersomnia, cognitive impairment, apathy, and derealization. These episodes are interspersed with long periods of normal sleep, cognition, and behavior. The pathogenesis of KLS is still unknown. The objective of this study was to determine serum cytokine levels in patients with KLS during and between episodes.PATIENTS/METHODS: Fifty-two typical KLS patients were included in the study of whom 17 patients donated blood samples both during and between episodes. Blood samples were collected in USA, France, and Taiwan in a clinical setting. Processing of the samples was performed at the Stanford Center for Sleep Sciences and Medicine.RESULTS: We did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age- and gender matched healthy controls (n = 8/group) whose blood samples were all collected and processed at the same day; asymptomatic KLS patients had significantly higher levels of serum sVCAM1 cytokine compared to healthy controls.CONCLUSION: These data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.

KW - Adolescent

KW - Adult

KW - Case-Control Studies

KW - Chemokines

KW - Cytokines

KW - Female

KW - Humans

KW - Interleukins

KW - Kleine-Levin Syndrome

KW - Male

KW - Middle Aged

KW - Young Adult

U2 - 10.1016/j.sleep.2015.02.540

DO - 10.1016/j.sleep.2015.02.540

M3 - Journal article

C2 - 26116465

VL - 16

SP - 961

EP - 965

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

IS - 8

ER -

ID: 162754090