Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer
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Sentinel European Node Trial (SENT) : 3-year results of sentinel node biopsy in oral cancer. / Schilling, Clare; Stoeckli, Sandro J; Haerle, Stephan K; Broglie, Martina A; Huber, Gerhard F; Sorensen, Jens Ahm; Bakholdt, Vivi; Krogdahl, Annelise; von Buchwald, Christian; Bilde, Anders; Sebbesen, Lars R; Odell, Edward; Gurney, Benjamin; O'Doherty, Michael; de Bree, Remco; Bloemena, Elisabeth; Flach, Geke B; Villarreal, Pedro M; Fresno Forcelledo, Manuel Florentino; Junquera Gutiérrez, Luis Manuel; Amézaga, Julio Alvarez; Barbier, Luis; Santamaría-Zuazua, Joseba; Moreira, Augusto; Jacome, Manuel; Vigili, Maurizio Giovanni; Rahimi, Siavash; Tartaglione, Girolamo; Lawson, Georges; Nollevaux, Marie-Cecile; Grandi, Cesare; Donner, Davide; Bragantini, Emma; Dequanter, Didier; Lothaire, Philippe; Poli, Tito; Silini, Enrico M; Sesenna, Erinco; Dolivet, Giles; Mastronicola, Romina; Leroux, Agnes; Sassoon, Isabel; Sloan, Philip; McGurk, Mark.
I: European journal of cancer (Oxford, England : 1990), Bind 51, Nr. 18, 12.2015, s. 2777-84.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Sentinel European Node Trial (SENT)
T2 - 3-year results of sentinel node biopsy in oral cancer
AU - Schilling, Clare
AU - Stoeckli, Sandro J
AU - Haerle, Stephan K
AU - Broglie, Martina A
AU - Huber, Gerhard F
AU - Sorensen, Jens Ahm
AU - Bakholdt, Vivi
AU - Krogdahl, Annelise
AU - von Buchwald, Christian
AU - Bilde, Anders
AU - Sebbesen, Lars R
AU - Odell, Edward
AU - Gurney, Benjamin
AU - O'Doherty, Michael
AU - de Bree, Remco
AU - Bloemena, Elisabeth
AU - Flach, Geke B
AU - Villarreal, Pedro M
AU - Fresno Forcelledo, Manuel Florentino
AU - Junquera Gutiérrez, Luis Manuel
AU - Amézaga, Julio Alvarez
AU - Barbier, Luis
AU - Santamaría-Zuazua, Joseba
AU - Moreira, Augusto
AU - Jacome, Manuel
AU - Vigili, Maurizio Giovanni
AU - Rahimi, Siavash
AU - Tartaglione, Girolamo
AU - Lawson, Georges
AU - Nollevaux, Marie-Cecile
AU - Grandi, Cesare
AU - Donner, Davide
AU - Bragantini, Emma
AU - Dequanter, Didier
AU - Lothaire, Philippe
AU - Poli, Tito
AU - Silini, Enrico M
AU - Sesenna, Erinco
AU - Dolivet, Giles
AU - Mastronicola, Romina
AU - Leroux, Agnes
AU - Sassoon, Isabel
AU - Sloan, Philip
AU - McGurk, Mark
N1 - Copyright © 2015. Published by Elsevier Ltd.
PY - 2015/12
Y1 - 2015/12
N2 - PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.
AB - PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Squamous Cell
KW - Chemoradiotherapy, Adjuvant
KW - Disease-Free Survival
KW - Europe
KW - False Negative Reactions
KW - Female
KW - Head and Neck Neoplasms
KW - Humans
KW - Kaplan-Meier Estimate
KW - Lymph Nodes
KW - Lymphatic Metastasis
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Neck Dissection
KW - Neoplasm Micrometastasis
KW - Neoplasm Staging
KW - Predictive Value of Tests
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Radiotherapy, Adjuvant
KW - Risk Factors
KW - Sentinel Lymph Node Biopsy
KW - Time Factors
KW - Treatment Outcome
U2 - 10.1016/j.ejca.2015.08.023
DO - 10.1016/j.ejca.2015.08.023
M3 - Journal article
C2 - 26597442
VL - 51
SP - 2777
EP - 2784
JO - European Journal of Cancer, Supplement
JF - European Journal of Cancer, Supplement
SN - 0959-8049
IS - 18
ER -
ID: 162753517