Schizophrenia genetic variants are not associated with intelligence
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Schizophrenia genetic variants are not associated with intelligence. / van Scheltinga, A F Terwisscha; Bakker, S C; van Haren, N E M; Derks, E M; Buizer-Voskamp, J E; Cahn, W; Ripke, S; Ophoff, R A; Kahn, R S; Psychiatric Genome-Wide Association Study (GWAS) Consortium ; Werge, Thomas Mears; Hansen, Thomas; Ingason, Andrés.
I: Psychological Medicine, 2013, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Schizophrenia genetic variants are not associated with intelligence
AU - van Scheltinga, A F Terwisscha
AU - Bakker, S C
AU - van Haren, N E M
AU - Derks, E M
AU - Buizer-Voskamp, J E
AU - Cahn, W
AU - Ripke, S
AU - Ophoff, R A
AU - Kahn, R S
AU - Psychiatric Genome-Wide Association Study (GWAS) Consortium
AU - Werge, Thomas Mears
AU - Hansen, Thomas
AU - Ingason, Andrés
PY - 2013
Y1 - 2013
N2 - BACKGROUND: Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence. Method IQ was estimated with the Wechsler Adult Intelligence Scale (WAIS). CNVs were determined from single nucleotide polymorphism (SNP) data using the QuantiSNP and PennCNV algorithms. For the PSS, odds ratios for genome-wide SNP data were calculated in a sample collected by the Psychiatric Genome-Wide Association Study (GWAS) Consortium (8690 schizophrenia patients and 11 831 controls). These were used to calculate individual PSSs in our independent sample of 350 schizophrenia patients and 322 healthy controls. RESULTS: Although significantly more genes were disrupted by deletions in schizophrenia patients compared to controls (p = 0.009), there was no effect of CNV measures on IQ. The PSS was associated with disease status (R 2 = 0.055, p = 2.1 × 10-7) and with IQ in the entire sample (R 2 = 0.018, p = 0.0008) but the effect on IQ disappeared after correction for disease status. CONCLUSIONS: Our data suggest that rare and common schizophrenia-associated variants do not explain the variation in IQ in healthy subjects or in schizophrenia patients. Thus, reductions in IQ in schizophrenia patients may be secondary to other processes related to schizophrenia risk.
AB - BACKGROUND: Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence. Method IQ was estimated with the Wechsler Adult Intelligence Scale (WAIS). CNVs were determined from single nucleotide polymorphism (SNP) data using the QuantiSNP and PennCNV algorithms. For the PSS, odds ratios for genome-wide SNP data were calculated in a sample collected by the Psychiatric Genome-Wide Association Study (GWAS) Consortium (8690 schizophrenia patients and 11 831 controls). These were used to calculate individual PSSs in our independent sample of 350 schizophrenia patients and 322 healthy controls. RESULTS: Although significantly more genes were disrupted by deletions in schizophrenia patients compared to controls (p = 0.009), there was no effect of CNV measures on IQ. The PSS was associated with disease status (R 2 = 0.055, p = 2.1 × 10-7) and with IQ in the entire sample (R 2 = 0.018, p = 0.0008) but the effect on IQ disappeared after correction for disease status. CONCLUSIONS: Our data suggest that rare and common schizophrenia-associated variants do not explain the variation in IQ in healthy subjects or in schizophrenia patients. Thus, reductions in IQ in schizophrenia patients may be secondary to other processes related to schizophrenia risk.
U2 - 10.1017/S0033291713000196
DO - 10.1017/S0033291713000196
M3 - Journal article
C2 - 23410598
SP - 1
EP - 8
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
ER -
ID: 48610602