Saliva in relation to dental erosion before and after radiotherapy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Saliva in relation to dental erosion before and after radiotherapy. / Jensdottir, Thorbjorg; von Buchwald, Christian; Nauntofte, Birgitte; Hansen, Hanne Sand; Jensen, Allan Bardow.
I: Acta Odontologica Scandinavica, Bind 71, Nr. 3-4, 2013, s. 1008.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Saliva in relation to dental erosion before and after radiotherapy
AU - Jensdottir, Thorbjorg
AU - von Buchwald, Christian
AU - Nauntofte, Birgitte
AU - Hansen, Hanne Sand
AU - Jensen, Allan Bardow
PY - 2013
Y1 - 2013
N2 - Abstract Objective. Low saliva flow and abnormal saliva composition are common conditions after radiotherapy for oral cavity and pharyngeal cancer. Both conditions increase the susceptibility to dental caries and erosion, which may be further accelerated by changes in food preferences. The aim of this study was to determine changes in saliva flow and susceptibility to erosive challenges in pharyngeal cancer patients before and after radiotherapy to the head and neck. Materials and methods: The erosive potential of sucking acidic candies with and without calcium was determined in nine patients (50-68 years) before and after receiving a radiation dose of 66 Gy to the head and neck area. The erosive potential was evaluated from saliva degree of saturation with respect to hydroxyapatite (HAp) and by dissolution of HAp in candy-stimulated saliva. Results. Sucking acidic candies increased saliva flow rates ∼ 17-fold before as well as after radiotherapy (p <0.001). However, significantly lower unstimulated (p <0.05) and stimulated (p <0.01) saliva flow rates were obtained after radiotherapy. Also, saliva became more under-saturated with respect to HAp during (p <0.01) and in a period after sucking the candies (p <0.01). HAp dissolution was significantly lower with the candy containing calcium compared with the control candy, both before and after radiotherapy (p <0.001 and p <0.05). Conclusions. Radiotherapy to the head and neck area significantly reduced saliva flow and altered saliva composition in a way that may increase the susceptibility to dental disease. However, saliva could be stimulated by acidic candies, which could be made nearly non-erosive even in irradiated patients.
AB - Abstract Objective. Low saliva flow and abnormal saliva composition are common conditions after radiotherapy for oral cavity and pharyngeal cancer. Both conditions increase the susceptibility to dental caries and erosion, which may be further accelerated by changes in food preferences. The aim of this study was to determine changes in saliva flow and susceptibility to erosive challenges in pharyngeal cancer patients before and after radiotherapy to the head and neck. Materials and methods: The erosive potential of sucking acidic candies with and without calcium was determined in nine patients (50-68 years) before and after receiving a radiation dose of 66 Gy to the head and neck area. The erosive potential was evaluated from saliva degree of saturation with respect to hydroxyapatite (HAp) and by dissolution of HAp in candy-stimulated saliva. Results. Sucking acidic candies increased saliva flow rates ∼ 17-fold before as well as after radiotherapy (p <0.001). However, significantly lower unstimulated (p <0.05) and stimulated (p <0.01) saliva flow rates were obtained after radiotherapy. Also, saliva became more under-saturated with respect to HAp during (p <0.01) and in a period after sucking the candies (p <0.01). HAp dissolution was significantly lower with the candy containing calcium compared with the control candy, both before and after radiotherapy (p <0.001 and p <0.05). Conclusions. Radiotherapy to the head and neck area significantly reduced saliva flow and altered saliva composition in a way that may increase the susceptibility to dental disease. However, saliva could be stimulated by acidic candies, which could be made nearly non-erosive even in irradiated patients.
U2 - 10.3109/00016357.2012.741704
DO - 10.3109/00016357.2012.741704
M3 - Journal article
C2 - 23167908
VL - 71
SP - 1008
JO - Acta Odontologica Scandinavica
JF - Acta Odontologica Scandinavica
SN - 0001-6357
IS - 3-4
ER -
ID: 38418545