Safety and feasibility of home-based chemotherapy
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Safety and feasibility of home-based chemotherapy. / Larsen, Finn Ole; Christiansen, Anne Birgitte; Rishøj, Anette; Nelausen, Knud Mejer; Nielsen, Dorte L.
I: Danish Medical Journal, Bind 65, Nr. 5, A5482, 2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Safety and feasibility of home-based chemotherapy
AU - Larsen, Finn Ole
AU - Christiansen, Anne Birgitte
AU - Rishøj, Anette
AU - Nelausen, Knud Mejer
AU - Nielsen, Dorte L
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient's preference.METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic. Patients with adverse events graded ≤ 2 on the Common Terminology Criteria for Adverse Events version 3.0 were randomised to either group A continuing with four treatments at home followed by three in an outpatient clinic, or to group B continuing with three treatments in an outpatient clinic followed by four at home. To assess quality of life, the EuroQol-5 Domain was used at baseline and before each treatment. Preference cards were used at baseline and at end of treatment.RESULTS: A total of 51 patients were included between 2007 and 2010. Forty-two patients continued in either group A or B. The nurse found that the treatment was safe and acceptable in all cases. In 145 cycles (99.3%), patients answered that they felt secure; only one patient answered: "Do not know". The highest-ranking preferences for patients were transportation time followed by waiting time.CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic.FUNDING: This study was supported by a grant from Roche.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient's preference.METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic. Patients with adverse events graded ≤ 2 on the Common Terminology Criteria for Adverse Events version 3.0 were randomised to either group A continuing with four treatments at home followed by three in an outpatient clinic, or to group B continuing with three treatments in an outpatient clinic followed by four at home. To assess quality of life, the EuroQol-5 Domain was used at baseline and before each treatment. Preference cards were used at baseline and at end of treatment.RESULTS: A total of 51 patients were included between 2007 and 2010. Forty-two patients continued in either group A or B. The nurse found that the treatment was safe and acceptable in all cases. In 145 cycles (99.3%), patients answered that they felt secure; only one patient answered: "Do not know". The highest-ranking preferences for patients were transportation time followed by waiting time.CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic.FUNDING: This study was supported by a grant from Roche.TRIAL REGISTRATION: not relevant.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Ambulatory Care Facilities
KW - Capecitabine/administration & dosage
KW - Chemotherapy, Adjuvant/adverse effects
KW - Colonic Neoplasms/drug therapy
KW - Cross-Over Studies
KW - Feasibility Studies
KW - Female
KW - Home Care Services
KW - Humans
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Organoplatinum Compounds/administration & dosage
KW - Oxaliplatin
KW - Patient Preference
KW - Patient Safety
KW - Quality of Life
M3 - Journal article
C2 - 29726319
VL - 65
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 5
M1 - A5482
ER -
ID: 217564801