Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans
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Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans. / Heinonen, Ilkka; Nesterov, Sergey V; Kemppainen, Jukka; Nuutila, Pirjo; Knuuti, Juhani; Laitio, Ruut; Kjaer, Michael; Boushel, Robert Christopher; Kalliokoski, Kari K.
I: Journal of Applied Physiology, Bind 103, Nr. 6, 01.12.2007, s. 2042-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans
AU - Heinonen, Ilkka
AU - Nesterov, Sergey V
AU - Kemppainen, Jukka
AU - Nuutila, Pirjo
AU - Knuuti, Juhani
AU - Laitio, Ruut
AU - Kjaer, Michael
AU - Boushel, Robert Christopher
AU - Kalliokoski, Kari K
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Evidence from both animal and human studies suggests that adenosine plays a role in the regulation of exercise hyperemia in skeletal muscle. We tested whether adenosine also plays a role in the regulation of blood flow (BF) distribution and heterogeneity among and within quadriceps femoris (QF) muscles during exercise, measured using positron emission tomography. In six healthy young women, BF was measured at rest and then during three incremental low and moderate intermittent isometric one-legged knee-extension exercise intensities without and with theophylline-induced nonselective adenosine receptor blockade. BF heterogeneity within muscles was calculated from 16-mm(3) voxels in BF images and heterogeneity among the muscles from the mean values of the four QF compartments. Mean BF in the whole QF and its four parts increased, and heterogeneity decreased with workload both without and with theophylline (P <0.001). Adenosine receptor blockade did not have any effect on mean bulk BF or BF heterogeneity among the QF muscles, yet blockade increased within-muscle BF heterogeneity in all four QF muscles (P = 0.03). Taken together, these results show that BF becomes less heterogeneous with increasing exercise intensity in the QF muscle group. Adenosine seems to play a role in muscle BF heterogeneity even in the absence of changes in bulk BF at low and moderate one-leg intermittent isometric exercise intensities.
AB - Evidence from both animal and human studies suggests that adenosine plays a role in the regulation of exercise hyperemia in skeletal muscle. We tested whether adenosine also plays a role in the regulation of blood flow (BF) distribution and heterogeneity among and within quadriceps femoris (QF) muscles during exercise, measured using positron emission tomography. In six healthy young women, BF was measured at rest and then during three incremental low and moderate intermittent isometric one-legged knee-extension exercise intensities without and with theophylline-induced nonselective adenosine receptor blockade. BF heterogeneity within muscles was calculated from 16-mm(3) voxels in BF images and heterogeneity among the muscles from the mean values of the four QF compartments. Mean BF in the whole QF and its four parts increased, and heterogeneity decreased with workload both without and with theophylline (P <0.001). Adenosine receptor blockade did not have any effect on mean bulk BF or BF heterogeneity among the QF muscles, yet blockade increased within-muscle BF heterogeneity in all four QF muscles (P = 0.03). Taken together, these results show that BF becomes less heterogeneous with increasing exercise intensity in the QF muscle group. Adenosine seems to play a role in muscle BF heterogeneity even in the absence of changes in bulk BF at low and moderate one-leg intermittent isometric exercise intensities.
U2 - 10.1152/japplphysiol.00567.2007
DO - 10.1152/japplphysiol.00567.2007
M3 - Journal article
C2 - 17885025
VL - 103
SP - 2042
EP - 2048
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -
ID: 4036247