Road and railway noise and risk for breast cancer: A nationwide study covering Denmark
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Road and railway noise and risk for breast cancer : A nationwide study covering Denmark. / Sørensen, Mette; Poulsen, Aslak Harbo; Kroman, Niels; Hvidtfeldt, Ulla Arthur; Thacher, Jesse Daniel; Roswall, Nina; Brandt, Jørgen; Frohn, Lise Marie; Jensen, Steen Solvang; Levin, Gregor; Raaschou-Nielsen, Ole.
I: Environmental Research, Bind 195, 110739, 04.2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Road and railway noise and risk for breast cancer
T2 - A nationwide study covering Denmark
AU - Sørensen, Mette
AU - Poulsen, Aslak Harbo
AU - Kroman, Niels
AU - Hvidtfeldt, Ulla Arthur
AU - Thacher, Jesse Daniel
AU - Roswall, Nina
AU - Brandt, Jørgen
AU - Frohn, Lise Marie
AU - Jensen, Steen Solvang
AU - Levin, Gregor
AU - Raaschou-Nielsen, Ole
N1 - Publisher Copyright: © 2021 Elsevier Inc.
PY - 2021/4
Y1 - 2021/4
N2 - Objective: Previous studies have suggested that transportation noise may increase risk for breast cancer, but existing literature is scarce and inconclusive. We aimed to investigate associations between road traffic and railway noise and risk for breast cancer across the entire Danish female population. Methods: For all 2.8 million residential addresses across Denmark, we modelled road and railway noise at the most and least exposed façades for the period 1990–2017. We calculated 10-year time-weighted mean noise exposure for 1.8 million women aged >35 years, of whom 66,006 developed breast cancer during follow-up from 2000 to 2017. We analysed data using Cox proportional hazards models with noise exposure included as 10-year running means and adjusted for a number of individual and area-level socioeconomic co-variates and air pollution with fine particles estimated for all addresses. Results: For exposures at the least exposed façade, we found that a 10 dB increase in 10-year time-weighted noise was associated with incidence rate ratios (IRRs) and 95% confidence intervals (CI) for breast cancer of 1.032 (1.019–1.046) for road noise and 1.023 (0.993–1.053) for railway noise. For exposures at the most exposed façade, the IRRs (95% CIs) were 1.012 (1.002–1.022) for road noise and 1.020 (1.001–1.039) for railway noise. Associations were strongest among women with human epidermal growth factor receptor 2 negative breast cancer. Conclusions: Road traffic and railway noise were associated with higher risk for breast cancer, especially noise at the least exposed façade, which is a proxy for noise exposure during sleep.
AB - Objective: Previous studies have suggested that transportation noise may increase risk for breast cancer, but existing literature is scarce and inconclusive. We aimed to investigate associations between road traffic and railway noise and risk for breast cancer across the entire Danish female population. Methods: For all 2.8 million residential addresses across Denmark, we modelled road and railway noise at the most and least exposed façades for the period 1990–2017. We calculated 10-year time-weighted mean noise exposure for 1.8 million women aged >35 years, of whom 66,006 developed breast cancer during follow-up from 2000 to 2017. We analysed data using Cox proportional hazards models with noise exposure included as 10-year running means and adjusted for a number of individual and area-level socioeconomic co-variates and air pollution with fine particles estimated for all addresses. Results: For exposures at the least exposed façade, we found that a 10 dB increase in 10-year time-weighted noise was associated with incidence rate ratios (IRRs) and 95% confidence intervals (CI) for breast cancer of 1.032 (1.019–1.046) for road noise and 1.023 (0.993–1.053) for railway noise. For exposures at the most exposed façade, the IRRs (95% CIs) were 1.012 (1.002–1.022) for road noise and 1.020 (1.001–1.039) for railway noise. Associations were strongest among women with human epidermal growth factor receptor 2 negative breast cancer. Conclusions: Road traffic and railway noise were associated with higher risk for breast cancer, especially noise at the least exposed façade, which is a proxy for noise exposure during sleep.
KW - Breast cancer
KW - Epidemiology
KW - Public health
KW - Transportation noise
U2 - 10.1016/j.envres.2021.110739
DO - 10.1016/j.envres.2021.110739
M3 - Journal article
C2 - 33460635
AN - SCOPUS:85099859363
VL - 195
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 110739
ER -
ID: 285511300