Risk of periodontitis in patients with psoriasis and psoriatic arthritis
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Risk of periodontitis in patients with psoriasis and psoriatic arthritis. / Egeberg, A; Mallbris, L; Gislason, G; Hansen, P R; Mrowietz, U.
I: Journal of the European Academy of Dermatology and Venereology, Bind 31, Nr. 2, 2017, s. 288-293.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Risk of periodontitis in patients with psoriasis and psoriatic arthritis
AU - Egeberg, A
AU - Mallbris, L
AU - Gislason, G
AU - Hansen, P R
AU - Mrowietz, U
N1 - © 2016 European Academy of Dermatology and Venereology.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Psoriasis and periodontitis are chronic inflammatory disorders with overlapping inflammatory pathways, but data on risk of periodontitis in psoriasis are scarce and a possible pathogenic link is poorly understood.OBJECTIVE: We investigated the association between psoriasis and periodontitis in a nationwide cohort study.METHODS: All Danish individuals aged ≥18 years between 1 January 1997 and 31 December 2011 (n = 5,470,428), including 54 210 and 6988 patients with mild and severe psoriasis, and 6428 with psoriatic arthritis, were linked through administrative registers. Incidence rate ratios (IRRs) were estimated by Poisson regression.RESULTS: Incidence rates of periodontitis per 10 000 person-years were 3.07 (3.03-3.12), 5.89 (1.07-6.84), 8.27 (5.50-12.45) and 11.12 (7.87-15.73) for the reference population, mild psoriasis, severe psoriasis and psoriatic arthritis respectively. Adjusted IRRs were (1.66; 1.43-1.94) for mild psoriasis, (2.24; 1.46-3.44) for severe psoriasis and (3.48; 2.46-4.92) for psoriatic arthritis. Similar results were found when a case-control design was applied.CONCLUSIONS: We found a significant psoriasis-associated increased risk of periodontitis, which was highest in patients with severe psoriasis and psoriatic arthritis.
AB - BACKGROUND: Psoriasis and periodontitis are chronic inflammatory disorders with overlapping inflammatory pathways, but data on risk of periodontitis in psoriasis are scarce and a possible pathogenic link is poorly understood.OBJECTIVE: We investigated the association between psoriasis and periodontitis in a nationwide cohort study.METHODS: All Danish individuals aged ≥18 years between 1 January 1997 and 31 December 2011 (n = 5,470,428), including 54 210 and 6988 patients with mild and severe psoriasis, and 6428 with psoriatic arthritis, were linked through administrative registers. Incidence rate ratios (IRRs) were estimated by Poisson regression.RESULTS: Incidence rates of periodontitis per 10 000 person-years were 3.07 (3.03-3.12), 5.89 (1.07-6.84), 8.27 (5.50-12.45) and 11.12 (7.87-15.73) for the reference population, mild psoriasis, severe psoriasis and psoriatic arthritis respectively. Adjusted IRRs were (1.66; 1.43-1.94) for mild psoriasis, (2.24; 1.46-3.44) for severe psoriasis and (3.48; 2.46-4.92) for psoriatic arthritis. Similar results were found when a case-control design was applied.CONCLUSIONS: We found a significant psoriasis-associated increased risk of periodontitis, which was highest in patients with severe psoriasis and psoriatic arthritis.
KW - Adolescent
KW - Adult
KW - Arthritis, Psoriatic/complications
KW - Denmark
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Periodontitis/complications
KW - Psoriasis/complications
KW - Young Adult
U2 - 10.1111/jdv.13814
DO - 10.1111/jdv.13814
M3 - Journal article
C2 - 27439545
VL - 31
SP - 288
EP - 293
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
IS - 2
ER -
ID: 194941238