TY - JOUR

T1 - Risk of asthma in heterozygous carriers for cystic fibrosis

T2 - A meta-analysis

AU - Nielsen, Anne Orholm

AU - Qayum, Sadaf

AU - Bouchelouche, Pierre Nourdine

AU - Laursen, Lars Christian

AU - Dahl, Ronald

AU - Dahl, Morten

PY - 2016

Y1 - 2016

N2 - Background Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma. Methods We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers. Results Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18–2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were > 18 years, or study size was ≥ 500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma. Conclusions The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.

AB - Background Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma. Methods We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers. Results Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18–2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were > 18 years, or study size was ≥ 500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma. Conclusions The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.

KW - Airway obstruction

KW - Asthma

KW - Cystic fibrosis

KW - Epidemiology

KW - Review

U2 - 10.1016/j.jcf.2016.06.001

DO - 10.1016/j.jcf.2016.06.001

M3 - Journal article

C2 - 27324553

AN - SCOPUS:84990063405

VL - 15

SP - 563

EP - 567

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

SN - 1569-1993

IS - 5

ER -