Risk for multiple sclerosis in dizygotic and monozygotic twins
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Risk for multiple sclerosis in dizygotic and monozygotic twins. / Hansen, Thomas; Skytthe, Axel; Stenager, Egon; Petersen, Hans Christian; Kyvik, Kirsten Ohm; Brønnum-Hansen, Henrik.
I: Multiple Sclerosis, Bind 11, Nr. 5, 2005, s. 500-3.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Risk for multiple sclerosis in dizygotic and monozygotic twins
AU - Hansen, Thomas
AU - Skytthe, Axel
AU - Stenager, Egon
AU - Petersen, Hans Christian
AU - Kyvik, Kirsten Ohm
AU - Brønnum-Hansen, Henrik
PY - 2005
Y1 - 2005
N2 - We investigated the risks of twins for multiple sclerosis (MS). Our data are linked registers of all Danish twins and of all Danes born between 1920 and 1970 in whom MS was diagnosed before 1997. We compared differences in the risks for MS by Cox regression and standardized incidence ratios. Our analyses suggest that dizygotic twins have an approximately 60% lower risk for MS than monozygotic twins and a 20% lower risk than singletons. Monozygotic twins appear to have a somewhat higher risk for MS than singletons albeit not statistically significant. We offer no biological explanation for our findings, but suggest that either sharing fetal life with a genotypically different individual is beneficial for the immune system or that there is a linkage between the genes that influence dizygotic twinning and other genes that protect against MS.
AB - We investigated the risks of twins for multiple sclerosis (MS). Our data are linked registers of all Danish twins and of all Danes born between 1920 and 1970 in whom MS was diagnosed before 1997. We compared differences in the risks for MS by Cox regression and standardized incidence ratios. Our analyses suggest that dizygotic twins have an approximately 60% lower risk for MS than monozygotic twins and a 20% lower risk than singletons. Monozygotic twins appear to have a somewhat higher risk for MS than singletons albeit not statistically significant. We offer no biological explanation for our findings, but suggest that either sharing fetal life with a genotypically different individual is beneficial for the immune system or that there is a linkage between the genes that influence dizygotic twinning and other genes that protect against MS.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Denmark
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Registries
KW - Risk Factors
KW - Twins, Dizygotic
KW - Twins, Monozygotic
M3 - Journal article
C2 - 16193884
VL - 11
SP - 500
EP - 503
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 5
ER -
ID: 44172140