Rho GTPase function in tumorigenesis
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Rho GTPase function in tumorigenesis. / Karlsson, R; Pedersen, Esben Ditlev Kølle; Wang, Zhipeng; Brakebusch, Cord.
I: BBA General Subjects, 2009.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Rho GTPase function in tumorigenesis
AU - Karlsson, R
AU - Pedersen, Esben Ditlev Kølle
AU - Wang, Zhipeng
AU - Brakebusch, Cord
PY - 2009
Y1 - 2009
N2 - Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.
AB - Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.
U2 - 10.1016/j.bbcan.2009.03.003
DO - 10.1016/j.bbcan.2009.03.003
M3 - Journal article
C2 - 19327386
JO - B B A - General Subjects
JF - B B A - General Subjects
SN - 0304-4165
ER -
ID: 12866297