Rescue of arrested RNA polymerase II complexes
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
In the past few months, several discoveries relating to the mechanism underlying transcription-coupled DNA repair (TCR) have been reported. These results make it timely to propose a hypothesis for how eukaryotic cells might deal with arrested RNA polymerase II (Pol II) complexes. In this model, the transcription-repair coupling factor Cockayne Syndrome B (or the yeast equivalent Rad26) uses DNA translocase activity to remodel the Pol II-DNA interface, possibly to push the polymerase past the obstruction or to remove it from the DNA so that repair can take place if the obstacle is a DNA lesion. However, when this action is not possible and Pol II is left irreversibly trapped on DNA, the polymerase is instead ubiquitylated and eventually removed by proteolysis.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Cell Science |
Vol/bind | 116 |
Udgave nummer | 3 |
Sider (fra-til) | 447-451 |
Antal sider | 5 |
ISSN | 0021-9533 |
DOI | |
Status | Udgivet - 1 feb. 2003 |
Eksternt udgivet | Ja |
ID: 331041682