Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control
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Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. / Kafka, Alexandra P; McLeod, Bernie J; Rades, Thomas; McDowell, Arlene.
I: Journal of controlled release : official journal of the Controlled Release Society, Bind 149, Nr. 3, 2011, s. 307-13.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control
AU - Kafka, Alexandra P
AU - McLeod, Bernie J
AU - Rades, Thomas
AU - McDowell, Arlene
N1 - Copyright © 2010 Elsevier B.V. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (
AB - Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (
U2 - 10.1016/j.jconrel.2010.10.029
DO - 10.1016/j.jconrel.2010.10.029
M3 - Journal article
C2 - 21047541
VL - 149
SP - 307
EP - 313
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
IS - 3
ER -
ID: 40343426