Relationship between body fat mass and free fatty acid kinetics in men and women
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Relationship between body fat mass and free fatty acid kinetics in men and women. / Mittendorfer, Bettina; Magkos, Faidon; Fabbrini, Elisa; Mohammed, B Selma; Klein, Samuel.
I: Obesity, Bind 17, Nr. 10, 2009, s. 1872-1877.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Relationship between body fat mass and free fatty acid kinetics in men and women
AU - Mittendorfer, Bettina
AU - Magkos, Faidon
AU - Fabbrini, Elisa
AU - Mohammed, B Selma
AU - Klein, Samuel
N1 - (Ekstern)
PY - 2009
Y1 - 2009
N2 - An increased release of free fatty acids (FFAs) into plasma likely contributes to the metabolic complications associated with obesity. However, the relationship between body fat and FFA metabolism is unclear because of conflicting results from different studies. The goal of our study was to determine the inter-relationships between body fat, sex, and plasma FFA kinetics. We determined FFA rate of appearance (Ra) in plasma, by using stable isotopically labeled tracer techniques, during basal conditions in 106 lean, overweight, and obese, nondiabetic subjects (43 men and 63 women who had 7.0-56.0% body fat). Correlation analyses demonstrated: (i) no differences between men and women in the relationship between fat mass (FM) and total FFA Ra (micromol/min); (ii) total FFA Ra increased linearly with increasing FM (r = 0.652, P < 0.001); (iii) FFA Ra per kg FM decreased in a curvilinear fashion with increasing FM (r = -0.806; P < 0.001); (iv) FFA Ra in relationship to fat-free mass (FFM) was greater in obese than lean subjects and greater in women than in men; and (v) abdominal fat itself was not an important determinant of total FFA Ra. We conclude that total body fat, not regional fat distribution or sex, is an important modulator of the rate of FFA release into plasma. Although increased adiposity is associated with a decrease in fatty acid release in relationship to FM, this downregulation is unable to completely compensate for the increase in FM, so total FFA Ra and FFA Ra with respect to FFM are greater in women than in men and in obese than in lean subjects.
AB - An increased release of free fatty acids (FFAs) into plasma likely contributes to the metabolic complications associated with obesity. However, the relationship between body fat and FFA metabolism is unclear because of conflicting results from different studies. The goal of our study was to determine the inter-relationships between body fat, sex, and plasma FFA kinetics. We determined FFA rate of appearance (Ra) in plasma, by using stable isotopically labeled tracer techniques, during basal conditions in 106 lean, overweight, and obese, nondiabetic subjects (43 men and 63 women who had 7.0-56.0% body fat). Correlation analyses demonstrated: (i) no differences between men and women in the relationship between fat mass (FM) and total FFA Ra (micromol/min); (ii) total FFA Ra increased linearly with increasing FM (r = 0.652, P < 0.001); (iii) FFA Ra per kg FM decreased in a curvilinear fashion with increasing FM (r = -0.806; P < 0.001); (iv) FFA Ra in relationship to fat-free mass (FFM) was greater in obese than lean subjects and greater in women than in men; and (v) abdominal fat itself was not an important determinant of total FFA Ra. We conclude that total body fat, not regional fat distribution or sex, is an important modulator of the rate of FFA release into plasma. Although increased adiposity is associated with a decrease in fatty acid release in relationship to FM, this downregulation is unable to completely compensate for the increase in FM, so total FFA Ra and FFA Ra with respect to FFM are greater in women than in men and in obese than in lean subjects.
KW - Absorptiometry, Photon
KW - Adipose Tissue/metabolism
KW - Adolescent
KW - Adult
KW - Blood Glucose/metabolism
KW - Fatty Acids, Nonesterified/blood
KW - Female
KW - Humans
KW - Insulin/blood
KW - Kinetics
KW - Male
KW - Middle Aged
KW - Obesity/blood
KW - Regression Analysis
KW - Young Adult
U2 - 10.1038/oby.2009.224
DO - 10.1038/oby.2009.224
M3 - Journal article
C2 - 19629053
VL - 17
SP - 1872
EP - 1877
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 10
ER -
ID: 290671515