Reduced serum concentrations of biomarkers reflecting leydig and sertoli cell function in male patients with congenital adrenal hyperplasia
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Reduced serum concentrations of biomarkers reflecting leydig and sertoli cell function in male patients with congenital adrenal hyperplasia. / Johannsen, Trine Holm; Albrethsen, Jakob; Neocleous, Vassos; Baronio, Federico; Cools, Martine; Aksglaede, Lise; Jørgensen, Niels; Christiansen, Peter; Toumba, Meropi; Fanis, Pavlos; Ljubicic, Marie Lindhardt; Juul, Anders.
I: Endocrine Connections, Bind 12, Nr. 8, e230073, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Reduced serum concentrations of biomarkers reflecting leydig and sertoli cell function in male patients with congenital adrenal hyperplasia
AU - Johannsen, Trine Holm
AU - Albrethsen, Jakob
AU - Neocleous, Vassos
AU - Baronio, Federico
AU - Cools, Martine
AU - Aksglaede, Lise
AU - Jørgensen, Niels
AU - Christiansen, Peter
AU - Toumba, Meropi
AU - Fanis, Pavlos
AU - Ljubicic, Marie Lindhardt
AU - Juul, Anders
N1 - Publisher Copyright: © 2023 the author(s).
PY - 2023
Y1 - 2023
N2 - Congenital adrenal hyperplasia (CAH) is a recessive condition t hat affects the adrenal glands. Despite life-long replacement therapy with glucocorticoids and mineralocorticoids, adult patients with CAH often experience impaired gonadal function. In pubertal boys and in men with CAH, circulating testosterone is produced by the adrenal glands as well as the testicular, steroidogenic cells. In this European two-center study, we evaluated the function of Leydig and Sertoli cells in 61 boys and men with CAH, primarily due to 21-hydroxylase deficiency. Despite conventional hormone replacement therapy, our results indicated a significant reduction in serum concentrations of both Leydig cel l-derived hormones (i.e. insulin-like factor 3 (INSL3) and testosterone) and Sertoli cell-derived hormones (i.e. inhibin B and anti-Müllerian hormone) in adult males with CAH. Serum concentrations of INSL3 were particularly reduced in those with testicular adrenal rest tumors. To our knowledge, this is the first study to evaluate circulating INSL3 as a candi date biomarker to monitor Leydig cell function in patients with CAH.
AB - Congenital adrenal hyperplasia (CAH) is a recessive condition t hat affects the adrenal glands. Despite life-long replacement therapy with glucocorticoids and mineralocorticoids, adult patients with CAH often experience impaired gonadal function. In pubertal boys and in men with CAH, circulating testosterone is produced by the adrenal glands as well as the testicular, steroidogenic cells. In this European two-center study, we evaluated the function of Leydig and Sertoli cells in 61 boys and men with CAH, primarily due to 21-hydroxylase deficiency. Despite conventional hormone replacement therapy, our results indicated a significant reduction in serum concentrations of both Leydig cel l-derived hormones (i.e. insulin-like factor 3 (INSL3) and testosterone) and Sertoli cell-derived hormones (i.e. inhibin B and anti-Müllerian hormone) in adult males with CAH. Serum concentrations of INSL3 were particularly reduced in those with testicular adrenal rest tumors. To our knowledge, this is the first study to evaluate circulating INSL3 as a candi date biomarker to monitor Leydig cell function in patients with CAH.
KW - AMH
KW - FSH
KW - Inhibin B
KW - INSL3
KW - LH
KW - Testosterone
U2 - 10.1530/EC-23-0073
DO - 10.1530/EC-23-0073
M3 - Journal article
C2 - 37256668
AN - SCOPUS:85169822455
VL - 12
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 8
M1 - e230073
ER -
ID: 386375138