Recurrence of sarcoid granulomas in lung transplant recipients is common and does not affect overall survival
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Recurrence of sarcoid granulomas in lung transplant recipients is common and does not affect overall survival. / Schultz, Hans Henrik Lawaetz; Andersen, Claus Bøgelund; Steinbrüchel, D; Perch, Michael; Carlsen, Jørn; Iversen, M.
I: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Bind 31, Nr. 2, 2014, s. 149-153.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Recurrence of sarcoid granulomas in lung transplant recipients is common and does not affect overall survival
AU - Schultz, Hans Henrik Lawaetz
AU - Andersen, Claus Bøgelund
AU - Steinbrüchel, D
AU - Perch, Michael
AU - Carlsen, Jørn
AU - Iversen, M
PY - 2014
Y1 - 2014
N2 - Background: Sarcoidosis represents 2,5% of all indications for lung transplantation and criteria are generally assumed to be the same as for pulmonary fibrosis. Recurrence of granulomas in transplanted lungs has earlier been proved to derive from recipient immune cells, but its role in relation to lung function and overall survival after lung transplantation remains uncertain. Objective: To identify recurrent granuloma in transbronchial biopsies in patients receiving lung transplant because of sarcoidosis, and relate the findings to overall survival and lung function. Design: A total of 620 patients were transplanted at this centre from 1992 until august 2012. This study comprised all patients (n=25) transplanted due to pulmonary sarcoidosis. Lung functions, trans-bronchial biopsies, and survival were compared in patients with and without recurrence of granulomas. Granulomas were defined as non-necrotizing epitheloid granulomas with multinucleated giant cells according to standard criteria (formation of epitheloid giant cells) without presence of infection. Conclusions: Approximately 30% of lung transplant recipients due to sarcoidosis have recurrence of sarcoid granulomas. Recurrence of granulomas does not affect overall survival or lung function.
AB - Background: Sarcoidosis represents 2,5% of all indications for lung transplantation and criteria are generally assumed to be the same as for pulmonary fibrosis. Recurrence of granulomas in transplanted lungs has earlier been proved to derive from recipient immune cells, but its role in relation to lung function and overall survival after lung transplantation remains uncertain. Objective: To identify recurrent granuloma in transbronchial biopsies in patients receiving lung transplant because of sarcoidosis, and relate the findings to overall survival and lung function. Design: A total of 620 patients were transplanted at this centre from 1992 until august 2012. This study comprised all patients (n=25) transplanted due to pulmonary sarcoidosis. Lung functions, trans-bronchial biopsies, and survival were compared in patients with and without recurrence of granulomas. Granulomas were defined as non-necrotizing epitheloid granulomas with multinucleated giant cells according to standard criteria (formation of epitheloid giant cells) without presence of infection. Conclusions: Approximately 30% of lung transplant recipients due to sarcoidosis have recurrence of sarcoid granulomas. Recurrence of granulomas does not affect overall survival or lung function.
M3 - Journal article
C2 - 25078643
VL - 31
SP - 149
EP - 153
JO - Sarcoidosis Vasculitis and Diffuse Lung Diseases
JF - Sarcoidosis Vasculitis and Diffuse Lung Diseases
SN - 1124-0490
IS - 2
ER -
ID: 137741598