Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Real-world approach to actinic keratosis management : practical treatment algorithm for office-based dermatology. / Dirschka, Thomas; Gupta, Girish; Micali, Giuseppe; Stockfleth, Eggert; Basset-Séguin, Nicole; Del Marmol, Véronique; Dummer, Reinhard; Jemec, Gregor B E; Malvehy, Josep; Peris, Ketty; Puig, Susana; Stratigos, Alexander J; Zalaudek, Iris; Pellacani, Giovanni.
I: Journal of Dermatological Treatment, Bind 28, Nr. 5, 2017, s. 431-442.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Real-world approach to actinic keratosis management
T2 - practical treatment algorithm for office-based dermatology
AU - Dirschka, Thomas
AU - Gupta, Girish
AU - Micali, Giuseppe
AU - Stockfleth, Eggert
AU - Basset-Séguin, Nicole
AU - Del Marmol, Véronique
AU - Dummer, Reinhard
AU - Jemec, Gregor B E
AU - Malvehy, Josep
AU - Peris, Ketty
AU - Puig, Susana
AU - Stratigos, Alexander J
AU - Zalaudek, Iris
AU - Pellacani, Giovanni
PY - 2017
Y1 - 2017
N2 - Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.
AB - Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.
KW - Algorithms
KW - Aminoquinolines/therapeutic use
KW - Antineoplastic Agents/therapeutic use
KW - Combined Modality Therapy
KW - Cryotherapy
KW - Disease Progression
KW - Humans
KW - Keratosis, Actinic/diagnosis
KW - Laser Therapy
U2 - 10.1080/09546634.2016.1254328
DO - 10.1080/09546634.2016.1254328
M3 - Review
C2 - 27796187
VL - 28
SP - 431
EP - 442
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
SN - 0954-6634
IS - 5
ER -
ID: 195501829