Radioactive seed localisation of non-palpable lymph nodes: A feasibility study
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Radioactive seed localisation of non-palpable lymph nodes : A feasibility study. / Hassing, C. M. S.; Tvedskov, T. F.; Kroman, N.; Klausen, T. L.; Drejoe, J. B.; Tvedskov, J. F.; Lambine, T. -L; Kledal, H.; Lelkaitis, G.; Langhans, L.
I: European Journal of Surgical Oncology, Bind 44, Nr. 5, 2018, s. 725-730.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Radioactive seed localisation of non-palpable lymph nodes
T2 - A feasibility study
AU - Hassing, C. M. S.
AU - Tvedskov, T. F.
AU - Kroman, N.
AU - Klausen, T. L.
AU - Drejoe, J. B.
AU - Tvedskov, J. F.
AU - Lambine, T. -L
AU - Kledal, H.
AU - Lelkaitis, G.
AU - Langhans, L.
PY - 2018
Y1 - 2018
N2 - BackgroundRadioactive seed localisation (RSL) is a preoperative localisation method using a small titanium seed containing iodine-125. The method is increasingly applied for localising non-palpable lesions in the treatment of breast cancer. We believe that RSL has the potential to be used in various surgical specialties. The aim of this feasibility study was to test RSL as a preoperative localisation of non-palpable lymph nodes.MethodsBetween November 24, 2015 and October 26, 2016, 15 patients with suspicious lymph nodes on imaging were included in the study. The lymph nodes were located in the axillary region (n = 9), the head and neck region (n = 5) and the inguinal region (n = 1). The seeds were placed in the centre of the lymph node, in the capsule or just outside the capsule guided by ultrasound. During surgery, incision and localisation of the lymph nodes were performed based on the auditory signal of the gamma probe. After excision, lymph nodes including iodine seeds were sent for pathologic examination and the seeds were returned to the Department of Nuclear Medicine.ResultsThe non-palpable lymph nodes were all successfully marked using ultrasound. The lymph nodes were successfully localised and excised during surgery, and the procedure was performed without complications in the majority of the cases.ConclusionLocalisation of suspicious non-palpable lymph nodes using RSL is feasible. RSL may ease the surgical procedure, minimise trauma to the surrounding tissue and ultimately benefit the patient. Future prospective studies are necessary to determine the further use of RSL within different surgical specialties.
AB - BackgroundRadioactive seed localisation (RSL) is a preoperative localisation method using a small titanium seed containing iodine-125. The method is increasingly applied for localising non-palpable lesions in the treatment of breast cancer. We believe that RSL has the potential to be used in various surgical specialties. The aim of this feasibility study was to test RSL as a preoperative localisation of non-palpable lymph nodes.MethodsBetween November 24, 2015 and October 26, 2016, 15 patients with suspicious lymph nodes on imaging were included in the study. The lymph nodes were located in the axillary region (n = 9), the head and neck region (n = 5) and the inguinal region (n = 1). The seeds were placed in the centre of the lymph node, in the capsule or just outside the capsule guided by ultrasound. During surgery, incision and localisation of the lymph nodes were performed based on the auditory signal of the gamma probe. After excision, lymph nodes including iodine seeds were sent for pathologic examination and the seeds were returned to the Department of Nuclear Medicine.ResultsThe non-palpable lymph nodes were all successfully marked using ultrasound. The lymph nodes were successfully localised and excised during surgery, and the procedure was performed without complications in the majority of the cases.ConclusionLocalisation of suspicious non-palpable lymph nodes using RSL is feasible. RSL may ease the surgical procedure, minimise trauma to the surrounding tissue and ultimately benefit the patient. Future prospective studies are necessary to determine the further use of RSL within different surgical specialties.
KW - Preoperative localisation
KW - Lymph node
KW - Non-palpable lesion
KW - Iodine seed
KW - Radioactive seed localisation
U2 - 10.1016/j.ejso.2018.02.211
DO - 10.1016/j.ejso.2018.02.211
M3 - Journal article
C2 - 29545086
VL - 44
SP - 725
EP - 730
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 5
ER -
ID: 209056889