Rad52 and Rad59 exhibit both overlapping and distinct functions

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Rad52 and Rad59 exhibit both overlapping and distinct functions. / Feng, Q; Düring, Louis; Mayolo, A. A. de; Lettier, G.; Lisby, M.; Erdeniz, N.; Mortensen, U. H.; Rothstein, R.

I: DNA Repair, Bind 6, Nr. 1, 2007, s. 27-37.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Feng, Q, Düring, L, Mayolo, AAD, Lettier, G, Lisby, M, Erdeniz, N, Mortensen, UH & Rothstein, R 2007, 'Rad52 and Rad59 exhibit both overlapping and distinct functions', DNA Repair, bind 6, nr. 1, s. 27-37. https://doi.org/10.1016/j.dnarep.2006.08.007

APA

Feng, Q., Düring, L., Mayolo, A. A. D., Lettier, G., Lisby, M., Erdeniz, N., Mortensen, U. H., & Rothstein, R. (2007). Rad52 and Rad59 exhibit both overlapping and distinct functions. DNA Repair, 6(1), 27-37. https://doi.org/10.1016/j.dnarep.2006.08.007

Vancouver

Feng Q, Düring L, Mayolo AAD, Lettier G, Lisby M, Erdeniz N o.a. Rad52 and Rad59 exhibit both overlapping and distinct functions. DNA Repair. 2007;6(1):27-37. https://doi.org/10.1016/j.dnarep.2006.08.007

Author

Feng, Q ; Düring, Louis ; Mayolo, A. A. de ; Lettier, G. ; Lisby, M. ; Erdeniz, N. ; Mortensen, U. H. ; Rothstein, R. / Rad52 and Rad59 exhibit both overlapping and distinct functions. I: DNA Repair. 2007 ; Bind 6, Nr. 1. s. 27-37.

Bibtex

@article{17528f806c3711dcbee902004c4f4f50,
title = "Rad52 and Rad59 exhibit both overlapping and distinct functions",
abstract = "Homologous recombination is an important pathway for the repair of DNA double-strand breaks (DSBs). In the yeast Saccharomyces cerevisiae, Rad52 is a central recombination protein, whereas its paralogue, Rad59, plays a more subtle role in homologous recombination. Both proteins can mediate annealing of complementary single-stranded DNA in vitro, but only Rad52 interacts with replication protein A and the Rad51 recombinase. We have studied the functional overlap between Rad52 and Rad59 in living cells using chimeras of the two proteins and site-directed mutagenesis. We find that Rad52 and Rad59 have both overlapping as well as separate functions in DSB repair. Importantly, the N-terminus of Rad52 possesses functions not supplied by Rad59, which may account for its central role in homologous recombination.",
author = "Q Feng and Louis D{\"u}ring and Mayolo, {A. A. de} and G. Lettier and M. Lisby and N. Erdeniz and Mortensen, {U. H.} and R. Rothstein",
note = "Keywords: Rad52; Rad59; Recombination foci; Homologous recombination; Saccharomyces cerevisiae",
year = "2007",
doi = "10.1016/j.dnarep.2006.08.007",
language = "English",
volume = "6",
pages = "27--37",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Rad52 and Rad59 exhibit both overlapping and distinct functions

AU - Feng, Q

AU - Düring, Louis

AU - Mayolo, A. A. de

AU - Lettier, G.

AU - Lisby, M.

AU - Erdeniz, N.

AU - Mortensen, U. H.

AU - Rothstein, R.

N1 - Keywords: Rad52; Rad59; Recombination foci; Homologous recombination; Saccharomyces cerevisiae

PY - 2007

Y1 - 2007

N2 - Homologous recombination is an important pathway for the repair of DNA double-strand breaks (DSBs). In the yeast Saccharomyces cerevisiae, Rad52 is a central recombination protein, whereas its paralogue, Rad59, plays a more subtle role in homologous recombination. Both proteins can mediate annealing of complementary single-stranded DNA in vitro, but only Rad52 interacts with replication protein A and the Rad51 recombinase. We have studied the functional overlap between Rad52 and Rad59 in living cells using chimeras of the two proteins and site-directed mutagenesis. We find that Rad52 and Rad59 have both overlapping as well as separate functions in DSB repair. Importantly, the N-terminus of Rad52 possesses functions not supplied by Rad59, which may account for its central role in homologous recombination.

AB - Homologous recombination is an important pathway for the repair of DNA double-strand breaks (DSBs). In the yeast Saccharomyces cerevisiae, Rad52 is a central recombination protein, whereas its paralogue, Rad59, plays a more subtle role in homologous recombination. Both proteins can mediate annealing of complementary single-stranded DNA in vitro, but only Rad52 interacts with replication protein A and the Rad51 recombinase. We have studied the functional overlap between Rad52 and Rad59 in living cells using chimeras of the two proteins and site-directed mutagenesis. We find that Rad52 and Rad59 have both overlapping as well as separate functions in DSB repair. Importantly, the N-terminus of Rad52 possesses functions not supplied by Rad59, which may account for its central role in homologous recombination.

U2 - 10.1016/j.dnarep.2006.08.007

DO - 10.1016/j.dnarep.2006.08.007

M3 - Journal article

VL - 6

SP - 27

EP - 37

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

IS - 1

ER -

ID: 1095346