Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism
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Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism. / Yaniv, Dan; Vainer, Igor; Amir, Ido; Robenshtok, Eyal; Hirsch, Dania; Watt, Torquil; Hilly, Ohad; Shkedy, Yotam; Shpitzer, Thomas; Bachar, Gideon; Feinmesser, Raphael; Mizrachi, Aviram.
I: Journal of Surgical Oncology, Bind 126, Nr. 4, 2022, s. 640-648.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism
AU - Yaniv, Dan
AU - Vainer, Igor
AU - Amir, Ido
AU - Robenshtok, Eyal
AU - Hirsch, Dania
AU - Watt, Torquil
AU - Hilly, Ohad
AU - Shkedy, Yotam
AU - Shpitzer, Thomas
AU - Bachar, Gideon
AU - Feinmesser, Raphael
AU - Mizrachi, Aviram
PY - 2022
Y1 - 2022
N2 - Objective The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy. Study Design Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery. Setting Tertiary medical center. Methods Thyroid specific QOL questionnaire analysis. Results A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4. Conclusions Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.
AB - Objective The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy. Study Design Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery. Setting Tertiary medical center. Methods Thyroid specific QOL questionnaire analysis. Results A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4. Conclusions Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.
KW - hypothyroidism
KW - PRO
KW - QOL
KW - thyroidectomy
KW - TSH
KW - ASSOCIATION MANAGEMENT GUIDELINES
KW - ADULT PATIENTS
KW - L-THYROXINE
KW - CANCER
KW - COGNITION
KW - SYMPTOMS
KW - NODULES
KW - MOOD
U2 - 10.1002/jso.26983
DO - 10.1002/jso.26983
M3 - Journal article
C2 - 35689620
VL - 126
SP - 640
EP - 648
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 4
ER -
ID: 314068275