Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Quality of dietary fat and genetic risk of type 2 diabetes : individual participant data meta-analysis. / Merino, Jordi; Guasch-Ferré, Marta; Ellervik, Christina; Dashti, Hassan S; Sharp, Stephen J; Wu, Peitao; Overvad, Kim; Sarnowski, Chloé; Kuokkanen, Mikko; Lemaitre, Rozenn N; Justice, Anne E; Ericson, Ulrika; Braun, Kim V E; Mahendran, Yuvaraj; Frazier-Wood, Alexis C; Sun, Dianjianyi; Chu, Audrey Y; Tanaka, Toshiko; Luan, Jian'an; Hong, Jaeyoung; Tjønneland, Anne; Ding, Ming; Lundqvist, Annamari; Mukamal, Kenneth; Rohde, Rebecca; Schulz, Christina-Alexandra; Franco, Oscar H; Grarup, Niels; Chen, Yii-Der Ida; Bazzano, Lydia; Franks, Paul W; Buring, Julie E; Langenberg, Claudia; Liu, Ching-Ti; Hansen, Torben; Jensen, Majken K; Sääksjärvi, Katri; Psaty, Bruce M; Young, Kristin L; Hindy, George; Sandholt, Camilla Helene; Ridker, Paul M; Ordovas, Jose M; Meigs, James B; Pedersen, Oluf; Kraft, Peter; Perola, Markus; North, Kari E; Orho-Melander, Marju; Voortman, Trudy; Toft, Ulla; Rotter, Jerome I; Qi, Lu; Forouhi, Nita G; Mozaffarian, Dariush; Sørensen, Thorkild I A; Stampfer, Meir J; Männistö, Satu; Selvin, Elizabeth; Imamura, Fumiaki; Salomaa, Veikko; Hu, Frank B; Wareham, Nick J; Dupuis, Josée; Smith, Caren E; Kilpeläinen, Tuomas O; Chasman, Daniel I; Florez, Jose C.
I: BMJ (Clinical research ed.), Bind 366, 2019, s. l4292.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Quality of dietary fat and genetic risk of type 2 diabetes
T2 - individual participant data meta-analysis
AU - Merino, Jordi
AU - Guasch-Ferré, Marta
AU - Ellervik, Christina
AU - Dashti, Hassan S
AU - Sharp, Stephen J
AU - Wu, Peitao
AU - Overvad, Kim
AU - Sarnowski, Chloé
AU - Kuokkanen, Mikko
AU - Lemaitre, Rozenn N
AU - Justice, Anne E
AU - Ericson, Ulrika
AU - Braun, Kim V E
AU - Mahendran, Yuvaraj
AU - Frazier-Wood, Alexis C
AU - Sun, Dianjianyi
AU - Chu, Audrey Y
AU - Tanaka, Toshiko
AU - Luan, Jian'an
AU - Hong, Jaeyoung
AU - Tjønneland, Anne
AU - Ding, Ming
AU - Lundqvist, Annamari
AU - Mukamal, Kenneth
AU - Rohde, Rebecca
AU - Schulz, Christina-Alexandra
AU - Franco, Oscar H
AU - Grarup, Niels
AU - Chen, Yii-Der Ida
AU - Bazzano, Lydia
AU - Franks, Paul W
AU - Buring, Julie E
AU - Langenberg, Claudia
AU - Liu, Ching-Ti
AU - Hansen, Torben
AU - Jensen, Majken K
AU - Sääksjärvi, Katri
AU - Psaty, Bruce M
AU - Young, Kristin L
AU - Hindy, George
AU - Sandholt, Camilla Helene
AU - Ridker, Paul M
AU - Ordovas, Jose M
AU - Meigs, James B
AU - Pedersen, Oluf
AU - Kraft, Peter
AU - Perola, Markus
AU - North, Kari E
AU - Orho-Melander, Marju
AU - Voortman, Trudy
AU - Toft, Ulla
AU - Rotter, Jerome I
AU - Qi, Lu
AU - Forouhi, Nita G
AU - Mozaffarian, Dariush
AU - Sørensen, Thorkild I A
AU - Stampfer, Meir J
AU - Männistö, Satu
AU - Selvin, Elizabeth
AU - Imamura, Fumiaki
AU - Salomaa, Veikko
AU - Hu, Frank B
AU - Wareham, Nick J
AU - Dupuis, Josée
AU - Smith, Caren E
AU - Kilpeläinen, Tuomas O
AU - Chasman, Daniel I
AU - Florez, Jose C
N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
PY - 2019
Y1 - 2019
N2 - OBJECTIVE: To investigate whether the genetic burden of type 2 diabetes modifies the association between the quality of dietary fat and the incidence of type 2 diabetes.DESIGN: Individual participant data meta-analysis.DATA SOURCES: Eligible prospective cohort studies were systematically sourced from studies published between January 1970 and February 2017 through electronic searches in major medical databases (Medline, Embase, and Scopus) and discussion with investigators.REVIEW METHODS: Data from cohort studies or multicohort consortia with available genome-wide genetic data and information about the quality of dietary fat and the incidence of type 2 diabetes in participants of European descent was sought. Prospective cohorts that had accrued five or more years of follow-up were included. The type 2 diabetes genetic risk profile was characterized by a 68-variant polygenic risk score weighted by published effect sizes. Diet was recorded by using validated cohort-specific dietary assessment tools. Outcome measures were summary adjusted hazard ratios of incident type 2 diabetes for polygenic risk score, isocaloric replacement of carbohydrate (refined starch and sugars) with types of fat, and the interaction of types of fat with polygenic risk score.RESULTS: Of 102 305 participants from 15 prospective cohort studies, 20 015 type 2 diabetes cases were documented after a median follow-up of 12 years (interquartile range 9.4-14.2). The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score was 1.64 (95% confidence interval 1.54 to 1.75, I2=7.1%, τ2=0.003). The increase of polyunsaturated fat and total omega 6 polyunsaturated fat intake in place of carbohydrate was associated with a lower risk of type 2 diabetes, with hazard ratios of 0.90 (0.82 to 0.98, I2=18.0%, τ2=0.006; per 5% of energy) and 0.99 (0.97 to 1.00, I2=58.8%, τ2=0.001; per increment of 1 g/d), respectively. Increasing monounsaturated fat in place of carbohydrate was associated with a higher risk of type 2 diabetes (hazard ratio 1.10, 95% confidence interval 1.01 to 1.19, I2=25.9%, τ2=0.006; per 5% of energy). Evidence of small study effects was detected for the overall association of polyunsaturated fat with the risk of type 2 diabetes, but not for the omega 6 polyunsaturated fat and monounsaturated fat associations. Significant interactions between dietary fat and polygenic risk score on the risk of type 2 diabetes (P>0.05 for interaction) were not observed.CONCLUSIONS: These data indicate that genetic burden and the quality of dietary fat are each associated with the incidence of type 2 diabetes. The findings do not support tailoring recommendations on the quality of dietary fat to individual type 2 diabetes genetic risk profiles for the primary prevention of type 2 diabetes, and suggest that dietary fat is associated with the risk of type 2 diabetes across the spectrum of type 2 diabetes genetic risk.
AB - OBJECTIVE: To investigate whether the genetic burden of type 2 diabetes modifies the association between the quality of dietary fat and the incidence of type 2 diabetes.DESIGN: Individual participant data meta-analysis.DATA SOURCES: Eligible prospective cohort studies were systematically sourced from studies published between January 1970 and February 2017 through electronic searches in major medical databases (Medline, Embase, and Scopus) and discussion with investigators.REVIEW METHODS: Data from cohort studies or multicohort consortia with available genome-wide genetic data and information about the quality of dietary fat and the incidence of type 2 diabetes in participants of European descent was sought. Prospective cohorts that had accrued five or more years of follow-up were included. The type 2 diabetes genetic risk profile was characterized by a 68-variant polygenic risk score weighted by published effect sizes. Diet was recorded by using validated cohort-specific dietary assessment tools. Outcome measures were summary adjusted hazard ratios of incident type 2 diabetes for polygenic risk score, isocaloric replacement of carbohydrate (refined starch and sugars) with types of fat, and the interaction of types of fat with polygenic risk score.RESULTS: Of 102 305 participants from 15 prospective cohort studies, 20 015 type 2 diabetes cases were documented after a median follow-up of 12 years (interquartile range 9.4-14.2). The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score was 1.64 (95% confidence interval 1.54 to 1.75, I2=7.1%, τ2=0.003). The increase of polyunsaturated fat and total omega 6 polyunsaturated fat intake in place of carbohydrate was associated with a lower risk of type 2 diabetes, with hazard ratios of 0.90 (0.82 to 0.98, I2=18.0%, τ2=0.006; per 5% of energy) and 0.99 (0.97 to 1.00, I2=58.8%, τ2=0.001; per increment of 1 g/d), respectively. Increasing monounsaturated fat in place of carbohydrate was associated with a higher risk of type 2 diabetes (hazard ratio 1.10, 95% confidence interval 1.01 to 1.19, I2=25.9%, τ2=0.006; per 5% of energy). Evidence of small study effects was detected for the overall association of polyunsaturated fat with the risk of type 2 diabetes, but not for the omega 6 polyunsaturated fat and monounsaturated fat associations. Significant interactions between dietary fat and polygenic risk score on the risk of type 2 diabetes (P>0.05 for interaction) were not observed.CONCLUSIONS: These data indicate that genetic burden and the quality of dietary fat are each associated with the incidence of type 2 diabetes. The findings do not support tailoring recommendations on the quality of dietary fat to individual type 2 diabetes genetic risk profiles for the primary prevention of type 2 diabetes, and suggest that dietary fat is associated with the risk of type 2 diabetes across the spectrum of type 2 diabetes genetic risk.
KW - Adult
KW - Alleles
KW - Diabetes Mellitus, Type 2/epidemiology
KW - Diet/adverse effects
KW - Dietary Fats/adverse effects
KW - Female
KW - Genome-Wide Association Study
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Risk Factors
U2 - 10.1136/bmj.l4292
DO - 10.1136/bmj.l4292
M3 - Journal article
C2 - 31345923
VL - 366
SP - l4292
JO - The BMJ
JF - The BMJ
SN - 0959-8146
ER -
ID: 239571955