TY - JOUR

T1 - Pulmonary embolism

T2 - Age specific temporal trends in incidence and mortality in Denmark 1999–2018

AU - Sonne-Holm, Emilie

AU - Kjærgaard, Jesper

AU - Bang, Lia E.

AU - Fosbøl, Emil

AU - Carlsen, Jørn

AU - Winther-Jensen, Matilde

N1 - Publisher Copyright: © 2021 Elsevier Ltd

PY - 2022

Y1 - 2022

N2 - Background: Through the last two decades the prevention, diagnosis and treatment of pulmonary embolism (PE) has evolved along with demographic changes. The influence of these current transformations is important in the assessment of the future burden of PE. We aimed to describe age specific temporal trends in incidence of first-time PE and subsequent mortality. Methods: We identified patients ≥18 years of age with a first-time in-hospital diagnosis of PE in Danish national registers. By dividing patients into seven age groups (18–34, 35–44, 45–54, 55–65, 65–74, 75–84, >85 years), age specific incidence and 1-year mortality rates were calculated for four different calendar periods between 1999 and 2018. Results: From 1999 to 2018 65,478 patients with a first-time PE were identified. PE incidence per 100,000 person years increased during the study period in all age-groups (18–34 years: 10 to 18, 35–44 years: 18 to 35, 45–54: 26 to 63, 55–64 years: 42 to 123, 65–74 years: 92 to 229, 75–84 years: 166 to 383 and >85 years: 155 to 417), ptrend <0.0001 for all. During the study period 1-year mortality rate decreased from 4 to 2 per 10 person years in patients aged 65–74 years and this trend was found in all age groups (ptrend = 0.0001 for all). Conclusion: Despite a decreasing mortality rate, incidence rate of PE increased in Denmark across all age groups from 1999 to 2018, reflecting improved sensitivity of diagnostic methods and changes in the burden of comorbid conditions, all together warranting a continuing need for early prevention of PE.

AB - Background: Through the last two decades the prevention, diagnosis and treatment of pulmonary embolism (PE) has evolved along with demographic changes. The influence of these current transformations is important in the assessment of the future burden of PE. We aimed to describe age specific temporal trends in incidence of first-time PE and subsequent mortality. Methods: We identified patients ≥18 years of age with a first-time in-hospital diagnosis of PE in Danish national registers. By dividing patients into seven age groups (18–34, 35–44, 45–54, 55–65, 65–74, 75–84, >85 years), age specific incidence and 1-year mortality rates were calculated for four different calendar periods between 1999 and 2018. Results: From 1999 to 2018 65,478 patients with a first-time PE were identified. PE incidence per 100,000 person years increased during the study period in all age-groups (18–34 years: 10 to 18, 35–44 years: 18 to 35, 45–54: 26 to 63, 55–64 years: 42 to 123, 65–74 years: 92 to 229, 75–84 years: 166 to 383 and >85 years: 155 to 417), ptrend <0.0001 for all. During the study period 1-year mortality rate decreased from 4 to 2 per 10 person years in patients aged 65–74 years and this trend was found in all age groups (ptrend = 0.0001 for all). Conclusion: Despite a decreasing mortality rate, incidence rate of PE increased in Denmark across all age groups from 1999 to 2018, reflecting improved sensitivity of diagnostic methods and changes in the burden of comorbid conditions, all together warranting a continuing need for early prevention of PE.

KW - Age

KW - Epidemiology

KW - Incidence

KW - Mortality

KW - Pulmonary embolism

U2 - 10.1016/j.thromres.2021.12.011

DO - 10.1016/j.thromres.2021.12.011

M3 - Journal article

C2 - 34959202

AN - SCOPUS:85121699454

VL - 210

SP - 12

EP - 19

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

ER -