Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark: A nationwide register-based cohort study
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Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark : A nationwide register-based cohort study. / Kenborg, Line; Andersen, Elisabeth W.; Duun-Henriksen, Anne Katrine; Jepsen, Jens R.M.; Doser, Karoline; Dalton, Susanne O.; Bidstrup, Pernille E.; Krøyer, Anja; Frederiksen, Line E.; Johansen, Christoffer; Østergaard, John R.; Hove, Hanne; Sørensen, Sven Asger; Riccardi, Vincent M.; Mulvihill, John J.; Winther, Jeanette F.
I: American Journal of Medical Genetics, Part A, Bind 185, Nr. 12, 2021, s. 3706-3716.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark
T2 - A nationwide register-based cohort study
AU - Kenborg, Line
AU - Andersen, Elisabeth W.
AU - Duun-Henriksen, Anne Katrine
AU - Jepsen, Jens R.M.
AU - Doser, Karoline
AU - Dalton, Susanne O.
AU - Bidstrup, Pernille E.
AU - Krøyer, Anja
AU - Frederiksen, Line E.
AU - Johansen, Christoffer
AU - Østergaard, John R.
AU - Hove, Hanne
AU - Sørensen, Sven Asger
AU - Riccardi, Vincent M.
AU - Mulvihill, John J.
AU - Winther, Jeanette F.
N1 - Publisher Copyright: © 2021 Wiley Periodicals LLC.
PY - 2021
Y1 - 2021
N2 - The aim of this study was to assess the risks of psychiatric disorders in a large cohort of 905 individuals with NF1 and 7614 population comparisons matched on sex and year of birth. The cohort was linked to the Danish Psychiatric Central Research Register to ascertain information on hospital contacts for psychiatric disorders based on the International Classification of Diseases version 8 and 10. The hazard ratio (HR) for a first psychiatric hospital contact was higher in girls (4.19, 95% confidence interval [CI] 1.81–9.69) and boys with NF1 (5.02, 95% CI 3.27–7.69) <7 years of age than in the population comparisons. Both sexes had increased HRs for developmental disorders, including attention deficit/hyperactivity disorders, autism spectrum disorders, and intellectual disabilities in childhood. Females with NF1 had also increased HRs for unipolar depression, other emotional and behavioral disorders, and severe stress reaction and adjustment disorders in early adulthood. The HRs for psychoses, schizophrenia, bipolar disorders, and substance abuse were similar in individuals with NF1 and the population comparisons. Finally, the cumulative incidence of a first hospital contact due to any psychiatric disorder by age 30 years was 35% (95% CI 29–41) in females and 28% (95% CI 19–37) in males with NF1. Thus, screening for psychiatric disorders may be important for early diagnosis and facilitation of appropriate and effective treatment in individuals with NF1.
AB - The aim of this study was to assess the risks of psychiatric disorders in a large cohort of 905 individuals with NF1 and 7614 population comparisons matched on sex and year of birth. The cohort was linked to the Danish Psychiatric Central Research Register to ascertain information on hospital contacts for psychiatric disorders based on the International Classification of Diseases version 8 and 10. The hazard ratio (HR) for a first psychiatric hospital contact was higher in girls (4.19, 95% confidence interval [CI] 1.81–9.69) and boys with NF1 (5.02, 95% CI 3.27–7.69) <7 years of age than in the population comparisons. Both sexes had increased HRs for developmental disorders, including attention deficit/hyperactivity disorders, autism spectrum disorders, and intellectual disabilities in childhood. Females with NF1 had also increased HRs for unipolar depression, other emotional and behavioral disorders, and severe stress reaction and adjustment disorders in early adulthood. The HRs for psychoses, schizophrenia, bipolar disorders, and substance abuse were similar in individuals with NF1 and the population comparisons. Finally, the cumulative incidence of a first hospital contact due to any psychiatric disorder by age 30 years was 35% (95% CI 29–41) in females and 28% (95% CI 19–37) in males with NF1. Thus, screening for psychiatric disorders may be important for early diagnosis and facilitation of appropriate and effective treatment in individuals with NF1.
KW - cohort study
KW - neurofibromatosis 1
KW - population-based
KW - psychiatric disorders
U2 - 10.1002/ajmg.a.62436
DO - 10.1002/ajmg.a.62436
M3 - Journal article
C2 - 34327813
AN - SCOPUS:85111539113
VL - 185
SP - 3706
EP - 3716
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 12
ER -
ID: 302542065