Proximity to overhead power lines and childhood leukaemia: an international pooled analysis
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Proximity to overhead power lines and childhood leukaemia : an international pooled analysis. / Amoon, Aryana T; Crespi, Catherine M; Ahlbom, Anders; Bhatnagar, Megha; Bray, Isabelle; Bunch, Kathryn J; Clavel, Jacqueline; Feychting, Maria; Hémon, Denis; Johansen, Christoffer; Kreis, Christian; Malagoli, Carlotta; Marquant, Fabienne; Pedersen, Camilla; Raaschou-Nielsen, Ole; Röösli, Martin; Spycher, Ben D; Sudan, Madhuri; Swanson, John; Tittarelli, Andrea; Tuck, Deirdre M; Tynes, Tore; Vergara, Ximena; Vinceti, Marco; Wünsch-Filho, Victor; Kheifets, Leeka.
I: British Journal of Cancer, Bind 119, Nr. 3, 2018, s. 364-373.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Proximity to overhead power lines and childhood leukaemia
T2 - an international pooled analysis
AU - Amoon, Aryana T
AU - Crespi, Catherine M
AU - Ahlbom, Anders
AU - Bhatnagar, Megha
AU - Bray, Isabelle
AU - Bunch, Kathryn J
AU - Clavel, Jacqueline
AU - Feychting, Maria
AU - Hémon, Denis
AU - Johansen, Christoffer
AU - Kreis, Christian
AU - Malagoli, Carlotta
AU - Marquant, Fabienne
AU - Pedersen, Camilla
AU - Raaschou-Nielsen, Ole
AU - Röösli, Martin
AU - Spycher, Ben D
AU - Sudan, Madhuri
AU - Swanson, John
AU - Tittarelli, Andrea
AU - Tuck, Deirdre M
AU - Tynes, Tore
AU - Vergara, Ximena
AU - Vinceti, Marco
AU - Wünsch-Filho, Victor
AU - Kheifets, Leeka
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.METHODS: We present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.RESULTS: There was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living < 50 m from 200 + kV power lines, the adjusted odds ratio for childhood leukaemia was 1.33 (95% CI: 0.92-1.93). The odds ratio was higher among children diagnosed before age 5 years. There was no association with calculated magnetic fields. Odds ratios remained unchanged with adjustment for potential confounders.CONCLUSIONS: In this first comprehensive pooled analysis of childhood leukaemia and distance to power lines, we found a small and imprecise risk for residences < 50 m of 200 + kV lines that was not explained by high magnetic fields. Reasons for the increased risk, found in this and many other studies, remains to be elucidated.
AB - BACKGROUND: Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.METHODS: We present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.RESULTS: There was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living < 50 m from 200 + kV power lines, the adjusted odds ratio for childhood leukaemia was 1.33 (95% CI: 0.92-1.93). The odds ratio was higher among children diagnosed before age 5 years. There was no association with calculated magnetic fields. Odds ratios remained unchanged with adjustment for potential confounders.CONCLUSIONS: In this first comprehensive pooled analysis of childhood leukaemia and distance to power lines, we found a small and imprecise risk for residences < 50 m of 200 + kV lines that was not explained by high magnetic fields. Reasons for the increased risk, found in this and many other studies, remains to be elucidated.
U2 - 10.1038/s41416-018-0097-7
DO - 10.1038/s41416-018-0097-7
M3 - Journal article
C2 - 29808013
VL - 119
SP - 364
EP - 373
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 3
ER -
ID: 214870541