Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy
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Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy. / Donnelly, Sarah R; Hinkle, Stefanie N; Rawal, Shristi; Grunnet, Louise G; Chavarro, Jorge E; Vaag, Allan; Wu, Jing; Damm, Peter; Mills, James L; Li, Mengying; Bjerregaard, Anne A; Thuesen, Anne Cathrine B; Gore-Langton, Robert E; Francis, Ellen C; Ley, Sylvia H; Hu, Frank B; Tsai, Michael Y; Olsen, Sjurdur F; Zhang, Cuilin.
I: Journal of Diabetes, Bind 11, Nr. 11, 11.2019, s. 895-905.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy
AU - Donnelly, Sarah R
AU - Hinkle, Stefanie N
AU - Rawal, Shristi
AU - Grunnet, Louise G
AU - Chavarro, Jorge E
AU - Vaag, Allan
AU - Wu, Jing
AU - Damm, Peter
AU - Mills, James L
AU - Li, Mengying
AU - Bjerregaard, Anne A
AU - Thuesen, Anne Cathrine B
AU - Gore-Langton, Robert E
AU - Francis, Ellen C
AU - Ley, Sylvia H
AU - Hu, Frank B
AU - Tsai, Michael Y
AU - Olsen, Sjurdur F
AU - Zhang, Cuilin
N1 - © 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
PY - 2019/11
Y1 - 2019/11
N2 - BACKGROUND: Women with gestational diabetes mellitus (GDM) may be at an increased risk of liver complications because chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking.METHODS: The Diabetes & Women's Health Study (2012-2014) examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort. Nine to 16 years postpartum, a clinical examination was performed, with measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, from which fatty liver scoring indices were calculated to assess liver fat score, fatty liver index, hepatic steatosis index, and liver fat percentage. Relative risks (RR) with 95% confidence intervals (CI) for elevated liver scoring indices by GDM status were assessed adjusting for major risk factors, including prepregnancy body mass index.RESULTS: Women with prior GDM had higher adjusted ALT and AST levels than women without GDM (by 6.7% [95% CI 1.7-12.0] and 4.8% [95% CI 0.6-9.1], respectively). Women with GDM also had adjusted increased risks for elevated liver fat score (RR 2.34; 95% CI 1.68-3.27), fatty liver index (RR 1.59; 95% CI 1.27-1.99), and hepatic steatosis index (RR 1.44; 95% CI 1.21-1.71).CONCLUSIONS: Women with GDM during pregnancy were at an increased risk for fatty liver 9 to 16 years postpartum. Gestational diabetes mellitus may serve as another risk indicator for the early identification and prevention of liver fat accumulation.
AB - BACKGROUND: Women with gestational diabetes mellitus (GDM) may be at an increased risk of liver complications because chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking.METHODS: The Diabetes & Women's Health Study (2012-2014) examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort. Nine to 16 years postpartum, a clinical examination was performed, with measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, from which fatty liver scoring indices were calculated to assess liver fat score, fatty liver index, hepatic steatosis index, and liver fat percentage. Relative risks (RR) with 95% confidence intervals (CI) for elevated liver scoring indices by GDM status were assessed adjusting for major risk factors, including prepregnancy body mass index.RESULTS: Women with prior GDM had higher adjusted ALT and AST levels than women without GDM (by 6.7% [95% CI 1.7-12.0] and 4.8% [95% CI 0.6-9.1], respectively). Women with GDM also had adjusted increased risks for elevated liver fat score (RR 2.34; 95% CI 1.68-3.27), fatty liver index (RR 1.59; 95% CI 1.27-1.99), and hepatic steatosis index (RR 1.44; 95% CI 1.21-1.71).CONCLUSIONS: Women with GDM during pregnancy were at an increased risk for fatty liver 9 to 16 years postpartum. Gestational diabetes mellitus may serve as another risk indicator for the early identification and prevention of liver fat accumulation.
U2 - 10.1111/1753-0407.12934
DO - 10.1111/1753-0407.12934
M3 - Journal article
C2 - 31001915
VL - 11
SP - 895
EP - 905
JO - Journal of Diabetes
JF - Journal of Diabetes
SN - 1753-0393
IS - 11
ER -
ID: 235918796