Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man
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Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man. / Antonova, Maria; Wienecke, Troels; Olesen, Jes; Ashina, Messoud.
I: Cephalalgia, Bind 31, Nr. 15, 2011, s. 1532-41.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man
AU - Antonova, Maria
AU - Wienecke, Troels
AU - Olesen, Jes
AU - Ashina, Messoud
PY - 2011
Y1 - 2011
N2 - During two decades of migraine provocation studies with naturally occurring signalling molecules, vasodilators such as prostaglandin E(2), prostaglandin I(2) (prostacyclin) and prostaglandin D(2) were shown to be able to induce headache in man. To elucidate the role of inflammation and vasodilatation in the generation of headache, we investigated whether the pro-inflammatory and vasoconstricting prostanoid prostaglandin F(2a) (PGF(2a)) would cause headache in a human model of headache.
AB - During two decades of migraine provocation studies with naturally occurring signalling molecules, vasodilators such as prostaglandin E(2), prostaglandin I(2) (prostacyclin) and prostaglandin D(2) were shown to be able to induce headache in man. To elucidate the role of inflammation and vasodilatation in the generation of headache, we investigated whether the pro-inflammatory and vasoconstricting prostanoid prostaglandin F(2a) (PGF(2a)) would cause headache in a human model of headache.
U2 - http://dx.doi.org/10.1177/0333102411423314
DO - http://dx.doi.org/10.1177/0333102411423314
M3 - Journal article
VL - 31
SP - 1532
EP - 1541
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 15
ER -
ID: 40140802