Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope

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Standard

Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope. / Ruwald, Martin Huth; Hansen, Morten Lock; Lamberts, Morten; Hansen, Carolina Malta; Vinther, Michael; Køber, Lars; Torp-Pedersen, Christian; Hansen, Jim; Gislason, Gunnar Hilmar.

I: Journal of the American College of Cardiology, 2012.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ruwald, MH, Hansen, ML, Lamberts, M, Hansen, CM, Vinther, M, Køber, L, Torp-Pedersen, C, Hansen, J & Gislason, GH 2012, 'Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope', Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.08.1024

APA

Ruwald, M. H., Hansen, M. L., Lamberts, M., Hansen, C. M., Vinther, M., Køber, L., Torp-Pedersen, C., Hansen, J., & Gislason, G. H. (2012). Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.08.1024

Vancouver

Ruwald MH, Hansen ML, Lamberts M, Hansen CM, Vinther M, Køber L o.a. Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope. Journal of the American College of Cardiology. 2012. https://doi.org/10.1016/j.jacc.2012.08.1024

Author

Ruwald, Martin Huth ; Hansen, Morten Lock ; Lamberts, Morten ; Hansen, Carolina Malta ; Vinther, Michael ; Køber, Lars ; Torp-Pedersen, Christian ; Hansen, Jim ; Gislason, Gunnar Hilmar. / Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope. I: Journal of the American College of Cardiology. 2012.

Bibtex

@article{3c4962f831a942e596a431ea2c746283,

title = "Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope",

abstract = "OBJECTIVE: This study sought to examine the risk of major cardiac adverse events and death in a nationwide cohort of patients without previous comorbidity admitted for syncope. BACKGROUND: Syncope is a common clinical event, but knowledge of prognosis is not fully elucidated in healthy individuals. METHODS: Patients without previous comorbidity admitted for syncope in Denmark from 2001 to 2009 were identified in nationwide administrative registries and matched by sex and age with 5 control subjects from the Danish population. The risk of death or recurrent syncope, implantation of pacemaker or implantable cardioverter-defibrillator, and cardiovascular hospitalization were analyzed with multivariable Cox proportional hazard models. RESULTS: We identified 37,017 patients with a first-time diagnosis of syncope and 185,085 control subjects; their median age was 47 years (interquartile range, 32 to 63 years) and 47% were male. A total of 3,023 (8.2%) and 14,251 (7.1%) deaths occurred in the syncope and the control population, respectively, yielding an event rate of 14.3 per 1,000 person-years (PY) in the syncope population. Multivariable Cox regression analysis demonstrated a significantly increased risk of all-cause mortality (hazard ratio [HR]: 1.06; 95% confidence interval [CI]: 1.02 to 1.10), cardiovascular hospitalization event rate of 26.5 per 1,000 PY (HR: 1.74; 95% CI: 1.68 to 1.80), recurrent syncope event rate of 45.1 per 1,000, stroke event rate of 6.8 per 1,000 PY (HR: 1.35; 95% CI: 1.27 to 1.44), and pacemaker or implantable cardioverter-defibrillator event rate of 4.2 per 1,000 PY (HR: 5.52; 95% CI: 4.67 to 5.73; p <0.0001). CONCLUSIONS: The first admission for syncope among healthy individuals significantly predicts the risk of all-cause mortality, stroke, cardiovascular hospitalization, device implantation, and recurrent syncope.",

author = "Ruwald, {Martin Huth} and Hansen, {Morten Lock} and Morten Lamberts and Hansen, {Carolina Malta} and Michael Vinther and Lars K{\o}ber and Christian Torp-Pedersen and Jim Hansen and Gislason, {Gunnar Hilmar}",

year = "2012",

doi = "10.1016/j.jacc.2012.08.1024",

language = "English",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope

AU - Ruwald, Martin Huth

AU - Hansen, Morten Lock

AU - Lamberts, Morten

AU - Hansen, Carolina Malta

AU - Vinther, Michael

AU - Køber, Lars

AU - Torp-Pedersen, Christian

AU - Hansen, Jim

AU - Gislason, Gunnar Hilmar

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: This study sought to examine the risk of major cardiac adverse events and death in a nationwide cohort of patients without previous comorbidity admitted for syncope. BACKGROUND: Syncope is a common clinical event, but knowledge of prognosis is not fully elucidated in healthy individuals. METHODS: Patients without previous comorbidity admitted for syncope in Denmark from 2001 to 2009 were identified in nationwide administrative registries and matched by sex and age with 5 control subjects from the Danish population. The risk of death or recurrent syncope, implantation of pacemaker or implantable cardioverter-defibrillator, and cardiovascular hospitalization were analyzed with multivariable Cox proportional hazard models. RESULTS: We identified 37,017 patients with a first-time diagnosis of syncope and 185,085 control subjects; their median age was 47 years (interquartile range, 32 to 63 years) and 47% were male. A total of 3,023 (8.2%) and 14,251 (7.1%) deaths occurred in the syncope and the control population, respectively, yielding an event rate of 14.3 per 1,000 person-years (PY) in the syncope population. Multivariable Cox regression analysis demonstrated a significantly increased risk of all-cause mortality (hazard ratio [HR]: 1.06; 95% confidence interval [CI]: 1.02 to 1.10), cardiovascular hospitalization event rate of 26.5 per 1,000 PY (HR: 1.74; 95% CI: 1.68 to 1.80), recurrent syncope event rate of 45.1 per 1,000, stroke event rate of 6.8 per 1,000 PY (HR: 1.35; 95% CI: 1.27 to 1.44), and pacemaker or implantable cardioverter-defibrillator event rate of 4.2 per 1,000 PY (HR: 5.52; 95% CI: 4.67 to 5.73; p <0.0001). CONCLUSIONS: The first admission for syncope among healthy individuals significantly predicts the risk of all-cause mortality, stroke, cardiovascular hospitalization, device implantation, and recurrent syncope.

AB - OBJECTIVE: This study sought to examine the risk of major cardiac adverse events and death in a nationwide cohort of patients without previous comorbidity admitted for syncope. BACKGROUND: Syncope is a common clinical event, but knowledge of prognosis is not fully elucidated in healthy individuals. METHODS: Patients without previous comorbidity admitted for syncope in Denmark from 2001 to 2009 were identified in nationwide administrative registries and matched by sex and age with 5 control subjects from the Danish population. The risk of death or recurrent syncope, implantation of pacemaker or implantable cardioverter-defibrillator, and cardiovascular hospitalization were analyzed with multivariable Cox proportional hazard models. RESULTS: We identified 37,017 patients with a first-time diagnosis of syncope and 185,085 control subjects; their median age was 47 years (interquartile range, 32 to 63 years) and 47% were male. A total of 3,023 (8.2%) and 14,251 (7.1%) deaths occurred in the syncope and the control population, respectively, yielding an event rate of 14.3 per 1,000 person-years (PY) in the syncope population. Multivariable Cox regression analysis demonstrated a significantly increased risk of all-cause mortality (hazard ratio [HR]: 1.06; 95% confidence interval [CI]: 1.02 to 1.10), cardiovascular hospitalization event rate of 26.5 per 1,000 PY (HR: 1.74; 95% CI: 1.68 to 1.80), recurrent syncope event rate of 45.1 per 1,000, stroke event rate of 6.8 per 1,000 PY (HR: 1.35; 95% CI: 1.27 to 1.44), and pacemaker or implantable cardioverter-defibrillator event rate of 4.2 per 1,000 PY (HR: 5.52; 95% CI: 4.67 to 5.73; p <0.0001). CONCLUSIONS: The first admission for syncope among healthy individuals significantly predicts the risk of all-cause mortality, stroke, cardiovascular hospitalization, device implantation, and recurrent syncope.

U2 - 10.1016/j.jacc.2012.08.1024

DO - 10.1016/j.jacc.2012.08.1024

M3 - Journal article

C2 - 23246392

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

ER -

ID: 48452926