PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53
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Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations.
Originalsprog | Engelsk |
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Tidsskrift | Clinical Cancer Research |
Vol/bind | 17 |
Udgave nummer | 9 |
Sider (fra-til) | 2830-2841 |
Antal sider | 12 |
ISSN | 1078-0432 |
DOI | |
Status | Udgivet - 1 maj 2011 |
ID: 33923684