Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age
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Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age. / Hansen, S; Strøm, M; Olsen, S F; Dahl, R; Hoffmann, H J; Granström, C; Rytter, D; Bech, B H; Linneberg, A; Maslova, E; Kiviranta, H; Rantakokko, P; Halldorsson, T I.
I: Clinical and Experimental Allergy, Bind 46, Nr. 2, 02.2016, s. 329-36.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age
AU - Hansen, S
AU - Strøm, M
AU - Olsen, S F
AU - Dahl, R
AU - Hoffmann, H J
AU - Granström, C
AU - Rytter, D
AU - Bech, B H
AU - Linneberg, A
AU - Maslova, E
AU - Kiviranta, H
AU - Rantakokko, P
AU - Halldorsson, T I
N1 - © 2015 John Wiley & Sons Ltd.
PY - 2016/2
Y1 - 2016/2
N2 - BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.
AB - BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.
KW - Chromatography, Gas
KW - Dichlorodiphenyl Dichloroethylene
KW - Environmental Exposure
KW - Environmental Pollutants
KW - Female
KW - Follow-Up Studies
KW - Hexachlorobenzene
KW - Humans
KW - Hypersensitivity
KW - Male
KW - Mass Spectrometry
KW - Maternal Exposure
KW - Polychlorinated Biphenyls
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Pulmonary Disease, Chronic Obstructive
KW - Respiratory Function Tests
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/cea.12631
DO - 10.1111/cea.12631
M3 - Journal article
C2 - 26333063
VL - 46
SP - 329
EP - 336
JO - Clinical Allergy
JF - Clinical Allergy
SN - 0954-7894
IS - 2
ER -
ID: 173161553