Precapillary sphincters maintain perfusion in the cerebral cortex
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Precapillary sphincters maintain perfusion in the cerebral cortex. / Grubb, Søren; Cai, Changsi; Hald, Bjørn O; Khennouf, Lila; Murmu, Reena Prity; Jensen, Aske G K; Fordsmann, Jonas; Zambach, Stefan; Lauritzen, Martin.
I: Nature Communications, Bind 11, Nr. 1, 395, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Precapillary sphincters maintain perfusion in the cerebral cortex
AU - Grubb, Søren
AU - Cai, Changsi
AU - Hald, Bjørn O
AU - Khennouf, Lila
AU - Murmu, Reena Prity
AU - Jensen, Aske G K
AU - Fordsmann, Jonas
AU - Zambach, Stefan
AU - Lauritzen, Martin
PY - 2020
Y1 - 2020
N2 - Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood flow control, a precapillary sphincter at the transition between the penetrating arteriole and first order capillary, linking blood flow in capillaries to the arteriolar inflow. The sphincters are encircled by contractile mural cells, which are capable of bidirectional control of the length and width of the enclosed vessel segment. The hemodynamic consequence is that precapillary sphincters can generate the largest changes in the cerebrovascular flow resistance of all brain vessel segments, thereby controlling capillary flow while protecting the downstream capillary bed and brain tissue from adverse pressure fluctuations. Cortical spreading depolarization constricts sphincters and causes vascular trapping of blood cells. Thus, precapillary sphincters are bottlenecks for brain capillary blood flow.
AB - Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood flow control, a precapillary sphincter at the transition between the penetrating arteriole and first order capillary, linking blood flow in capillaries to the arteriolar inflow. The sphincters are encircled by contractile mural cells, which are capable of bidirectional control of the length and width of the enclosed vessel segment. The hemodynamic consequence is that precapillary sphincters can generate the largest changes in the cerebrovascular flow resistance of all brain vessel segments, thereby controlling capillary flow while protecting the downstream capillary bed and brain tissue from adverse pressure fluctuations. Cortical spreading depolarization constricts sphincters and causes vascular trapping of blood cells. Thus, precapillary sphincters are bottlenecks for brain capillary blood flow.
U2 - 10.1038/s41467-020-14330-z
DO - 10.1038/s41467-020-14330-z
M3 - Journal article
C2 - 31959752
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 395
ER -
ID: 234954006