Posture changes platelet inhibition time after ingestion of prasugrel
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Posture changes platelet inhibition time after ingestion of prasugrel. / Antonsen, Jacob; Bundgaard, Nina; Holmvang, Lene; Engstrøm, Thomas; Iversen, Kasper.
I: Danish Medical Journal, Bind 65, Nr. 10, A5504, 2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Posture changes platelet inhibition time after ingestion of prasugrel
AU - Antonsen, Jacob
AU - Bundgaard, Nina
AU - Holmvang, Lene
AU - Engstrøm, Thomas
AU - Iversen, Kasper
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: Several studies have suggested that supine posture during pill ingestion prolongs oesophageal transit time. Whether ingesting prasugrel in an upright position leads to reduced platelet reactivity during percutaneous coronary intervention remains unclear.METHODS: A total of 20 people were randomly assigned to ingest 60 mg of prasugrel in either the supine or upright position. Platelet reactivity was analysed using the point-of-care assay VerifyNow.RESULTS: In the upright position, the velocity of platelet inhibition was highest between 20 and 40 min. (Δ = 101.9 P2Y12 reaction units (PRU)). In the supine position, the highest value was seen between 40 and 60 min. (Δ = 56.85 PRU). Time to reach the cut-off for reducing peri- and post-operative risk of thrombosis showed a mean difference of 8 min. in favour of the upright group.CONCLUSIONS: A trend towards faster reduction of platelet reactivity was seen when ingesting prasugrel in the upright position compared with the supine position.FUNDING: This work was supported by Oda and Hans Svenningsens Foundation (grant number: BOF-10109). The foundation had no part in the collection, analysis or interpretation of data, or in the writing of the report or the decision to submit the work for publication.TRIAL REGISTRATION: This trial was registered with clinicaltrials.gov (NCT01365741).
AB - INTRODUCTION: Several studies have suggested that supine posture during pill ingestion prolongs oesophageal transit time. Whether ingesting prasugrel in an upright position leads to reduced platelet reactivity during percutaneous coronary intervention remains unclear.METHODS: A total of 20 people were randomly assigned to ingest 60 mg of prasugrel in either the supine or upright position. Platelet reactivity was analysed using the point-of-care assay VerifyNow.RESULTS: In the upright position, the velocity of platelet inhibition was highest between 20 and 40 min. (Δ = 101.9 P2Y12 reaction units (PRU)). In the supine position, the highest value was seen between 40 and 60 min. (Δ = 56.85 PRU). Time to reach the cut-off for reducing peri- and post-operative risk of thrombosis showed a mean difference of 8 min. in favour of the upright group.CONCLUSIONS: A trend towards faster reduction of platelet reactivity was seen when ingesting prasugrel in the upright position compared with the supine position.FUNDING: This work was supported by Oda and Hans Svenningsens Foundation (grant number: BOF-10109). The foundation had no part in the collection, analysis or interpretation of data, or in the writing of the report or the decision to submit the work for publication.TRIAL REGISTRATION: This trial was registered with clinicaltrials.gov (NCT01365741).
KW - Administration, Oral
KW - Adult
KW - Blood Platelets/drug effects
KW - Cross-Over Studies
KW - Humans
KW - Male
KW - Platelet Aggregation Inhibitors/administration & dosage
KW - Prasugrel Hydrochloride/administration & dosage
KW - Standing Position
KW - Supine Position
KW - Time Factors
KW - Young Adult
M3 - Journal article
C2 - 30269747
VL - 65
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 10
M1 - A5504
ER -
ID: 217558777