Plasma glucose is not associated with performance on standard cognitive screening tests in a mixed memory clinic cohort—An observational cross-sectional study
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Plasma glucose is not associated with performance on standard cognitive screening tests in a mixed memory clinic cohort—An observational cross-sectional study. / Gramkow, Mathias Holsey; Simonsen, Anja Hviid; Hasselbalch, Steen Gregers; Waldemar, Gunhild; Frederiksen, Kristian Steen.
I: International Journal of Geriatric Psychiatry, Bind 38, Nr. 7, e5968, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Plasma glucose is not associated with performance on standard cognitive screening tests in a mixed memory clinic cohort—An observational cross-sectional study
AU - Gramkow, Mathias Holsey
AU - Simonsen, Anja Hviid
AU - Hasselbalch, Steen Gregers
AU - Waldemar, Gunhild
AU - Frederiksen, Kristian Steen
N1 - Publisher Copyright: © 2023 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Background: It has been shown under experimental conditions that cognitive performance, especially working memory, is impaired in patients with type I and type II diabetes mellitus during hyperglycemic and hypoglycemic conditions, perhaps due to altered cerebral glucose metabolism. It is not known if patients with neurodegenerative diseases, who also exhibit pathological cerebral glucose metabolism, are affected in a similar manner by their plasma glucose levels. Objective: We aimed to test if performance on two cognitive screening tests was associated with plasma glucose levels in a memory clinic cohort. Methods: We included patients from the Copenhagen Memory Clinic Cohort with an available Mini Mental-State Examination (MMSE) test score and a plasma glucose measurement performed in conjunction with cognitive testing. We built linear regression models with MMSE and Addenbrooke's Cognitive Examination (ACE) test scores as the outcome and plasma glucose as the explaining variable and adjusted models for age, sex, and diabetes (plasma glucose measurement >11.1 mmol/L). We explored non-linear relationships by adding quadratic terms and by fitting a cubic spline regression model. Results: In total, 2714 patients had an available MMSE score and a plasma glucose measurement. MMSE and ACE total scores were not associated with plasma glucose in a linear or non-linear fashion when we adjusted for age, sex, and diabetes. Conclusion: Plasma glucose levels, predominantly within normal ranges, were not associated with performance on routinely applied cognitive tests and do not need to be taken into consideration when interpreting test results from memory clinic patients.
AB - Background: It has been shown under experimental conditions that cognitive performance, especially working memory, is impaired in patients with type I and type II diabetes mellitus during hyperglycemic and hypoglycemic conditions, perhaps due to altered cerebral glucose metabolism. It is not known if patients with neurodegenerative diseases, who also exhibit pathological cerebral glucose metabolism, are affected in a similar manner by their plasma glucose levels. Objective: We aimed to test if performance on two cognitive screening tests was associated with plasma glucose levels in a memory clinic cohort. Methods: We included patients from the Copenhagen Memory Clinic Cohort with an available Mini Mental-State Examination (MMSE) test score and a plasma glucose measurement performed in conjunction with cognitive testing. We built linear regression models with MMSE and Addenbrooke's Cognitive Examination (ACE) test scores as the outcome and plasma glucose as the explaining variable and adjusted models for age, sex, and diabetes (plasma glucose measurement >11.1 mmol/L). We explored non-linear relationships by adding quadratic terms and by fitting a cubic spline regression model. Results: In total, 2714 patients had an available MMSE score and a plasma glucose measurement. MMSE and ACE total scores were not associated with plasma glucose in a linear or non-linear fashion when we adjusted for age, sex, and diabetes. Conclusion: Plasma glucose levels, predominantly within normal ranges, were not associated with performance on routinely applied cognitive tests and do not need to be taken into consideration when interpreting test results from memory clinic patients.
KW - cognition
KW - cognitive test
KW - dementia
KW - diabetes mellitus
KW - diagnosis
KW - glucose
KW - glucose metabolism
KW - memory
KW - memory clinic
KW - neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85164980836&partnerID=8YFLogxK
U2 - 10.1002/gps.5968
DO - 10.1002/gps.5968
M3 - Journal article
C2 - 37458494
AN - SCOPUS:85164980836
VL - 38
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 7
M1 - e5968
ER -
ID: 369344116