Physiological Genetics Reformed: Bridging the Genome-to-Phenome Gap by Coherent Chemical Fingerprints – the Global Coordinator
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Physiological Genetics Reformed : Bridging the Genome-to-Phenome Gap by Coherent Chemical Fingerprints – the Global Coordinator. / Munck, Lars; Rinnan, Åsmund; Khakimov, Bekzod; Jespersen, Birthe Møller; Engelsen, Søren Balling.
I: Trends in Plant Science, Bind 26, Nr. 4, 2021, s. 324-337.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Physiological Genetics Reformed
T2 - Bridging the Genome-to-Phenome Gap by Coherent Chemical Fingerprints – the Global Coordinator
AU - Munck, Lars
AU - Rinnan, Åsmund
AU - Khakimov, Bekzod
AU - Jespersen, Birthe Møller
AU - Engelsen, Søren Balling
PY - 2021
Y1 - 2021
N2 - Forward-focused molecular genetics is successfully framing DNA diversity and mapping primary gene functions. However, abandoning the classic Linnaean fingerprint link between the phenome and genome by suppressing gene interaction (pleiotropy), has resulted in a genome-to-phenome gap and poor utilization of molecular data. We demonstrate how to bridge this gap by using an example of a barley mutant seed model, where pleiotropy is observed as covarying global molecular patterns that define each endosperm. Global coherence was discovered as a covariate coordinator within and between local genotype specific fingerprints. This implies that any of these fingerprints can select its recombinant global phenotype variant, including composition. Introducing the law of coherence, and the movement of gene complexes by chemical fingerprint traits as selectors, introduces a revolution in understanding physiological molecular genetics and plant-breeding.
AB - Forward-focused molecular genetics is successfully framing DNA diversity and mapping primary gene functions. However, abandoning the classic Linnaean fingerprint link between the phenome and genome by suppressing gene interaction (pleiotropy), has resulted in a genome-to-phenome gap and poor utilization of molecular data. We demonstrate how to bridge this gap by using an example of a barley mutant seed model, where pleiotropy is observed as covarying global molecular patterns that define each endosperm. Global coherence was discovered as a covariate coordinator within and between local genotype specific fingerprints. This implies that any of these fingerprints can select its recombinant global phenotype variant, including composition. Introducing the law of coherence, and the movement of gene complexes by chemical fingerprint traits as selectors, introduces a revolution in understanding physiological molecular genetics and plant-breeding.
KW - chemical fingerprints
KW - coherence in physiological genetics
KW - genome-to-phenome gap
KW - near infrared spectroscopy
KW - plant breeding
KW - self-organization in natural calculations
U2 - 10.1016/j.tplants.2020.12.014
DO - 10.1016/j.tplants.2020.12.014
M3 - Journal article
C2 - 33526341
AN - SCOPUS:85100402128
VL - 26
SP - 324
EP - 337
JO - Trends in Plant Science
JF - Trends in Plant Science
SN - 1360-1385
IS - 4
ER -
ID: 257968554