Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia
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Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia. / Olsen, Mette Frahm; Kæstel, Pernille; Tesfaye, M; Abdissa, A; Yilma, D; Girma, T; Mølgaard, Christian; Faurholt-Jepsen, D; Christensen, Dirk Lund; Brage, S; Andersen, A B; Friis, Henrik.
I: Epidemiology and Infection, Bind 143, Nr. 5, 2015, s. 1048-1058.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia
AU - Olsen, Mette Frahm
AU - Kæstel, Pernille
AU - Tesfaye, M
AU - Abdissa, A
AU - Yilma, D
AU - Girma, T
AU - Mølgaard, Christian
AU - Faurholt-Jepsen, D
AU - Christensen, Dirk Lund
AU - Brage, S
AU - Andersen, A B
AU - Friis, Henrik
N1 - CURIS 2015 NEXS 094
PY - 2015
Y1 - 2015
N2 - SUMMARY We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27·9 (interquartile range 17·4-39·8) kJ/kg per day and mean±s.d. grip strength was 23·6 ± 6·7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0·001) and -1·0 kg grip strength (P < 0·001). Grip strength was 4·2 kg lower in patients compared to HIV-negative individuals (P < 0·001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0·001) and -6·8 kg grip strength (P < 0·001) compared to BMI ⩾18·5. The study shows that advanced HIV and malnutrition are associated with considerably lower levels of physical activity and capacity in patients at initiation of antiretroviral treatment.
AB - SUMMARY We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27·9 (interquartile range 17·4-39·8) kJ/kg per day and mean±s.d. grip strength was 23·6 ± 6·7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0·001) and -1·0 kg grip strength (P < 0·001). Grip strength was 4·2 kg lower in patients compared to HIV-negative individuals (P < 0·001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0·001) and -6·8 kg grip strength (P < 0·001) compared to BMI ⩾18·5. The study shows that advanced HIV and malnutrition are associated with considerably lower levels of physical activity and capacity in patients at initiation of antiretroviral treatment.
U2 - 10.1017/S0950268814001502
DO - 10.1017/S0950268814001502
M3 - Journal article
C2 - 25034136
VL - 143
SP - 1048
EP - 1058
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 5
ER -
ID: 162906719